Histrelin
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Grundinformationen
- CAS
76712-82-8- Standard-SMILES
CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1cn(Cc2ccccc2)cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1- InChIKey
HHXHVIJIIXKSOE-QILQGKCVSA-N- Summenformel
- C66H86N18O12
- Durchschnittliche Molmasse
- 1.323,528 g/mol
- Monoisotopische Masse
- 1.322,66726019
Namen und Bezeichner
- Bevorzugter Name
- Histrelin
- IUPAC
- 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-N~5~-(diaminomethylidene)-L-ornithyl-N-ethyl-L-prolinamide
- Englischer Name
- Histrelin
- Summenformel
- C66H86N18O12
- Molmasse
- 1323.53
Namen und Synonyme
histrelin acetatePYR-HIS-TRP-SER-TYR-D-HIS(BZL)-LEU-ARG-PRO-NHET1-9-LUTEINIZING HORMONE-RELEASING FACTOR (SWINE), 6-[1-(PHENYLMETHYL)-D-HISTIDINE]-9-(N-ETHYL-L-PROLINAMIDE)-N-[1-[[1-[[1-[[1-[[1-[[1-[[5-(diaminomethylideneamino)-1-[2-(ethylcarbamoyl)-1-pyrrolidinyl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-[1-(phenylmethyl)-4-imidazolyorf17070SupprelinRWJ-17070HISTRELINAmyridineHistreline Acetate
Datenbank-Bezeichner
- CAS
76712-82-8- PubChem CID
- 25077993
- DTXSID
DTXSID50227543- ChEMBL
CHEMBL1201255- ChEBI
CHEBI:5739- UNII
- H50H3S3W74
- EC Number
- 636-025-4
- Nikkaji
- J39.173E
Eigenschaften
Physikochemische Eigenschaften
- Dichte
- 1.46 · 1.46±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · -20°C
- Löslichkeit
- Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- powder
- pka
- 9.82 · 9.82±0.15(Predicted)
- Stabilität
- Hygroscopic
- InChIKey
- HHXHVIJIIXKSOE-HMGGNIPDNA-N
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- hs_code
- 3504009000
- RTECS-Nr.
- OK6370800
- risk_code
- 60
- hazard_code
- T
- safety_code
- 53-22-36/37/39-45
- Speicherklasse
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- Giftige Stoffe Daten
- 76712-82-8(Hazardous Substances Data)
- Hazard Classifications
- Repr. 1B
Chemie und Industrie
Anwendungen
BeschreibungHistrelin, a synthetic gonadotrophin-releasing hormone (GnRH) agonist, was introduced as a first-line therapy for the treatment of central precocious puberty. When administered over a prolonged period, it suppresses the release of gonadotrophin, inhibits ovarian and testicular steroidogenesis, and prevents sexual maturation. Superior to the traditional therapy with progestational agents, histrelin appears to have decelerating effects on skeletal maturation allowing more statural growth and significantly increased final adult height. Histrelin has also been used to treat other disorders including endometriosis, polycystic ovarian disease, uterine leiomyomas, severe premenstrual syndrome and to prevent acute intermittent porphyria.
VerwendenLHRH agonist.
Ergänzende Hinweise
DefinitionChEBI: An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, 1-benzyl-D-histidyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. It is a synthetic nonapeptide analogue of gonadotro in-releasing hormone, and is used as a subcutaneous hydrogel implant (particularly as the diacetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.
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