Luteinizing hormone-releasing factor (swine), 6-D-tryptophan-, acetate (1:1)
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Grundinformationen
- CAS
140194-24-7- Standard-SMILES
CC(=O)O.CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O- InChIKey
HPPONSCISKROOD-OYLNGHKZSA-N- Summenformel
- C66H86N18O15
- Durchschnittliche Molmasse
- 1.371,525 g/mol
- Monoisotopische Masse
- 1.370,65200405
Namen und Bezeichner
- Bevorzugter Name
- Luteinizing hormone-releasing factor (swine), 6-D-tryptophan-, acetate (1:1)
- Englischer Name
- Triptorelin acetate
- Summenformel
- C64H82N18O13.C2H4O2
- Molmasse
- 1371.5
Namen und Synonyme
TRIPTORELIN ACETATEOvuGelLHRH-A3AY 25650Wy 42422Wy 42462BIM 21003BIM 21003CDecapeptyl-DepotTriptelin Acetate
Datenbank-Bezeichner
- CAS
140194-24-7、160296-12-8- PubChem CID
- 25080282
- DTXSID
DTXSID301033427- EC Number
- 689-180-5
Eigenschaften
Physikochemische Eigenschaften
- Löslichkeit
- Aqueous Base (Slightly), Methanol (Very Slightly, Heated, Sonicated), Water (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Stabilität
- Hygroscopic
- InChIKey
- HPPONSCISKROOD-UXTGTKPXNA-N
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- Alarmwort
- Achtung
- Gefahrenhinweise
- Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H360
Chemie und Industrie
Anwendungen
BeschreibungTriptorelin acetate (TA) is a GnRH agonist that was earlier used as a veterinary drug for a single fixed-time artificial insemination through the synchronised estrous cycle of weaned sows. The risk assessment was that the Food Safety Commission of Japan (FSCJ) concluded that TA is not likely to cause adverse effects on human health through dietary exposure. Because TA does not have genotoxicity relevant to human health and is degraded in the digestive tract, its oral bioavailability is low. TA is currently used for the treatment of central precocious puberty and assisted reproduction. Injectable TA alone or in combination with levonorgestrel intrauterine device is also used to treat endometrial atypical hyperplasia (EAH) . Combination therapy is more effective, improving patients' menstrual abnormalities, endometrial thickening and quality of life, and is safe.
VerwendenSynthetic peptide agonist analog of LH-RH. Triptorelin acetate is a potent agonist of LH-releasing hormone, currently used in the treatment of prostatic cancer where therapy may be required over months or years. Antineoplastic (hormonal). Used in the treatment of endometriosis and infertility.
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