Kisspeptin-10
KISSPEPTIN-10 · Kisspetin-10 · Kisspeptin-10 Fragment · METASTIN (45-54) · Kisspeptin-10 acetate · KiSS-1 · KISS-10 · YNWNSFGLRF - NH2
Identifikatoren & physikalische Daten
| CAS No. | 374675-21-5 |
|---|---|
| Summenformel | C63H83N17O14 |
| Durchschnittliche Molmasse | 1.302,4 g/mol |
| Monoisotopische Masse | 1.301,63054039 g/mol |
| SMILES | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |
| InChIKey | RITKWYDZSSQNJI-INXYWQKQSA-N |
| PubChem CID | 25240297 |
| ChEMBL | CHEMBL376756 |
Chemische & physikalische Eigenschaften
| XLogP | -1,9 |
|---|---|
| Polarare Oberfläche (TPSA) | 538 |
| H-Brücken-Donoren | 18 |
| H-Brücken-Akzeptoren | 16 |
| Frei drehbare Bindungen | 38 |
| Schwere Atome | 94 |
| Formalladung | 0 |
| Komplexität | 2.590 |
| Dichte | 1.46±0.1 g/cm3(Predicted) |
| Lagerbedingungen | -20°C |
| Löslichkeit | DMF: 15 mg/mlDMSO: 15 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.33 mg/mlSoluble in water at 1mg/ml |
| Aggregatzustand | A crystalline solid |
| pKa (Säurekonstante) | 9.96±0.15(Predicted) |
| Farbe | White to off-white |
| InChIKey | RITKWYDZSSQNJI-INXYWQKQSA-N |
Sicherheit & Vorschriften
| Wassergefährdungsklasse (WGK) | 3 |
|---|---|
| Lagerklasse | 11 - Combustible Solids |
Anwendungen & Verwendung
Beschreibung
Kisspeptin-10, also called Metastin (45-54), is a 10 amino acid peptide that corresponds to the bioactive C-terminal 45-54 amino acids of metastin, a metastasis suppressor gene product. It acts as a potent agonist of GPR54 (OT7T175, AXOR12), with approximately 8-fold higher binding affinity than metastin (Ki values of 0.042 and 0.34 nM, respectively, for displacement of metastin (40-54)). Metastin (45-54) induces calcium mobilization in GPR54-transfected cells (EC50 = 0.18-1.1 nM). It inhibits the migration of GPR54-transfected CHO cells at concentrations of 10-100 nM, equaling the potency of full length metastin.
Verwenden
Kisspeptin 10 (human) is a powerful and specific activator for AXOR12 and hOT7T175 receptors. The Kisspeptin 10 (human) amide has been utilized in studies involving progesterone release from MA-10 cells and in experiments to induce gonadal differentiation in clownfish.
Verwenden
Kisspeptin-10 (human), a member of the kisspeptin family, is a neuropeptide that regulates gonadotropin secretion. It has anti-angiogenic effects, a concentration-dependent inhibition of HUVEC proliferation and migration, and is highly expressed in the placenta, which may help to regulate angiogenesis in this tissue. Kisspeptin-10 (human) is currently undergoing clinical studies with insulin secretion in men. It is also a potential drug target for the treatment of infertility.