Imifoplatin
Grundinformationen
- CAS
1339960-28-9- Standard-SMILES
N[C@@H]1CCCC[C@H]1N.O=P([O-])(O)OP(=O)([O-])O.[Pt+2]- InChIKey
SCMHTXQHAHWVSX-BNTLRKBRSA-L- Summenformel
- C6H16N2O7P2Pt
- Durchschnittliche Molmasse
- 485,23 g/mol
- Monoisotopische Masse
- 485,008069
Überblick
Imifoplatin is a platinum (Pt)-based agent belonging to the phosphaplatin family comprised of Pt complexed to a pyrophosphate ligand, with potential antineoplastic activity. Although the exact mechanisms through which imifoplatin exerts its effect have yet to be fully elucidated, this agent, upon intravenous administration, binds to certain transmembrane proteins and activates several genes involved in tumor suppression and apoptosis. This leads to the activation of various signal transduction pathways, induces S/G2 phase cell cycle, and causes tumor cell apoptosis. In addition, imifoplatin may inhibit angiogenesis. Unlike conventional Pt-based chemotherapeutics, imifoplatin does not bind to DNA and is able to overcome drug resistance, which occurs with conventional Pt-based chemotherapeutics; it also has a more favorable side effect profile and is more stable in plasma.
Namen und Bezeichner
- Bevorzugter Name
- Imifoplatin
- IUPAC
- [hydroxy(oxido)phosphoryl] hydrogen phosphate;platinum(2+);trans-(1R,2R)-cyclohexane-1,2-diamine
- Englischer Name
- Platinate(2-), [(1R,2R)-1,2-cyclohexanediamine-κN1,κN2][diphosphato(4-)-κO,κO'']-, hydrogen (1:2), (SP-4-2)-
- Summenformel
- C6H13N2O7P2Pt-
- Molmasse
- 482.21
Namen und Synonyme
Imifoplatin [USAN]UNII-F5I3T42BXCCyclohexanediamine pyrophosphatoplatinum(II), (1R,2R)-F5I3T42BXCPT-112IMIFOPLATIN [INN]DTXSID30158447CYCLOHEXANE-(1R,2R)-DIAMINEPLATINUM(II) DIPHOSPHATE1,2-CYCLOHEXANEDIAMINE PYROPHOSPHATOPLATINUM(II), (R,R)-DIHYDROGEN (SP-4-2)-((1R,2R)-CYCLOHEXANE-1,2-DIAMINE-.KAPPA.2N1,N2)(DIPHOSPHATO(4)-.KAPPA.2O1,O3)PLATINATE(2)PLATINATE(2-), ((1R,2R)-1,2-CYCLOHEXANEDIAMINE-.KAPPA.N1,.KAPPA.N2)(DIPHOSPHATO(4-)-.KAPPA.O,.KAPPA.O'')-, HYDROGEN (1:2), (SP-4-2)-Phosphaplatin PT-112
Weitere Namen anzeigen
Platinate(2-), [(1R,2R)-1,2-cyclohexanediamine-κN1,κN2][diphosphato(4-)-κO,κO'']-, hydrogen (1:2), (SP-4-2)-
RefChem:148002DTXCID7080938PT 112 [WHO-DD]Pt 112(1R,2R)-1,2-cyclohexane-diaminepyrophosphato-platinum(II)DIHYDROGEN (SP-4-2)-((1R,2R)-CYCLOHEXANE-1,2-DIAMINE-KAPPA2N1,N2)(DIPHOSPHATO(4)-KAPPA2O1,O3)PLATINATE(2)PLATINATE(2-), ((1R,2R)-1,2-CYCLOHEXANEDIAMINE-KAPPAN1,KAPPAN2)(DIPHOSPHATO(4-)-KAPPAO,KAPPAO'')-, HYDROGEN (1:2), (SP-4-2)-Imifoplatin
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 182 Ų
- H-Brücken-Donoren
- 4
- H-Brücken-Akzeptoren
- 9
- Frei drehbare Bindungen
- 2
- Schwere Atome
- 18
- Formalladung
- 0
- Komplexität
- 206
Physikochemische Eigenschaften
- storage temp.
- -20 °C · Store at -20°C
- Aggregatzustand
- Solid
- Farbe
- White to off-white
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