Rose Bengal

HCID 25473

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Grundinformationen

CAS: 11121-48-5
Standard-SMILES: O=C([O-])c1c(Cl)c(Cl)c(Cl)c(Cl)c1-c1c2cc(I)c(=O)c(I)c-2oc2c(I)c([O-])c(I)cc12.[K+].[K+]
InChIKey: AZJPTIGZZTZIDR-UHFFFAOYSA-L
Summenformel: C20H2Cl4I4K2O5
Durchschnittliche Molmasse: 1.049,8 g/mol
Monoisotopische Masse: 1.047,4109

Überblick

Rose bengal is an organic potassium salt that is the dipotassium salt of 2,3,4,5-tetrachloro-6-(2,4,5,7-tetraiodo-6-hydroxy-3-oxoxanthen-9-yl)benzoic acid. It has a role as a fluorochrome and a histological dye. It is a xanthene dye and an organic potassium salt. It contains a rose bengal(2-). It is functionally related to a fluorescin.

Namen und Bezeichner

Bevorzugter Name: Rose Bengal
IUPAC: dipotassium;2,3,4,5-tetrachloro-6-(2,4,5,7-tetraiodo-3-oxido-6-oxoxanthen-9-yl)benzoate
Englischer Name: Rose bengal
Summenformel: C20H2Cl4I4Na2O5
Molmasse: 1017.64

Namen und Synonyme

Bengal rose11121-48-5Red No. 105C. I. 45440Food red dye 1051ZPG1ELY14Bengal, RoseRefChem:883728DTXSID20110074601-063-2C.I. 45440Rose Bengal

Weitere Namen anzeigen

RBroseROSE BENGAL DISODIUM SALTPV-10CI 45435redno.105LIF ELISAIFN-α ELISA

Rose bengaleC.I. Acid Red 94rose bengal potassiumFood red no 105ROSE BENGALE Bdipotassium 2,3,4,5-tetrachloro-6-(2,4,5,7-tetraiodo-6-oxido-3-oxo-3H-xanthen-9-yl)benzoatedipotassium;2,3,4,5-tetrachloro-6-(2,4,5,7-tetraiodo-3-oxido-6-oxoxanthen-9-yl)benzoateBenzoic acid, 2,3,4,5-tetrachloro-6-(6-hydroxy-2,4,5,7-tetraiodo-3-oxo-3H-xanthen-9-yl)-, dipotassium salt

Datenbank-Bezeichner

CAS: 11121-48-5、24545-87-7、632-68-8
PubChem CID: 25473
DTXSID: DTXSID601015268
ChEMBL: CHEMBL1160160、CHEMBL594741
ChEBI: CHEBI:52261
UNII: 1ZPG1ELY14
EC Number: 601-063-2
Nikkaji: J77.653J

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA): 89,5 Å²
H-Brücken-Donoren: 0
H-Brücken-Akzeptoren: 5
Frei drehbare Bindungen: 1
Schwere Atome: 35
Formalladung: 0
Komplexität: 936

Experimentelle und physikochemische Eigenschaften

Melting PointDecomposes

Physikochemische Eigenschaften

storage temp.: 2 · Keep in dark place,Inert atmosphere,2-8°C
Aggregatzustand: frozen liquid
Farbe: clear colorless
Biologische Quelle: mouse
EPA chemische Informationen: Rose Bengal (11121-48-5)

Sicherheit und Regulatorisches

Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.

Sicherheitsdaten

wgk: 3
hs_code: 29329990
RTECS-Nr.: LM5920000
risk_code: 36
hazard_code: Xi
safety_code: 22-24/25
Speicherklasse: 10 - Combustible liquids

Chemie und Industrie

Pharmakologische Informationen

Protein Binding · 1 Eintrag

Tear component comprising of different proteins, such as albumin (although not very common as tear component), lactoferrin, and transferrin, can bind to rose bengal dye and act as diffusion barrier to prevent dye uptake by cells and subsequent cell staining. Lysosymes in tear film can also bind to rose bengal to form precipitates to attenuate cell uptake.

Pharmacodynamics · 1 Eintrag

Rose bengal is a staining agent that visualized ocular surfaces of both diseased and dead cells _in vivo_. It has also shown to stain healthy cultured cells, including rabbit corneal epithelial cells, in a rapid, dose-dependent manner. Various studies demonstrate the cytotoxic effects of rose bengal in different cell cultures, including smooth-muscle cells from human intestine, endothelial cells from bovinepulmonary artery, rabbit Tenon fibro-blasts, and rabbit and human corneal epithelial cells. Cellular morphological changes such as detachment, separation, loss of motility and disruption, in addition to swelling, intracytoplasmic vacuole formation and lysis have been manifested with the treatment of rose bengal, indicating that rose Bengal is not a vital dye.

Mechanism of Action · 1 Eintrag

Rose Bengal stains both the nuclei and cell walls of dead or degenerated epithelial cells of the cornea and conjunctiva, and stain the mucus of the precorneal tear film. It is proposed that the staining ability of rose bengal is dependent on the status of tear film protection rather than cell viability, as tear components such as albumin and mucin can block the rose bengal uptake. It induces intrinsic cytotoxic effects by causing cellular morphologic changes, subsequent loss of cellular motility, cell detachment, and cell death. It mediates inhibitory actions on bovine corneal endothelial cells and attenuates cell proliferation.

Biological Half-LifeDoses between 0.01 and 10 mg/kg in rat resulted in an initial biological half-life of 2 min and a terminal half-life of 100 min. The biological half-life for excretion is around 30 minutes in rats and rabbits.

Metabolism/MetabolitesNo information available.

MeSH Pharmacological Classification · 1 Eintrag

Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.

Vor- und nachgelagerte Produkte

Vorgelagerte Rohstoffe

iodine

Anbieter37 Anbieter

成都超九八生物科技有限公司13348960310 13348960310 · [email protected]

郑州汇聚化工有限公司0371-53399770 18037166334 · [email protected]

陕西缔都化学有限公司029-029-81123119 17391733320 · [email protected]

Shenyang Simchoice Chemical Co.,Ltd+86-024-23769576 +86-15040101888 · [email protected]

北京索莱宝科技有限公司010-50973130 17801761073 · [email protected]

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