61422-45-5CCCCCCNC(=O)n1cc(F)c(=O)[nH]c1=OAOCCBINRVIKJHY-UHFFFAOYSA-N61422-45-5DTXSID2045941CHEMBL460499CHEBI:31360153.85 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards];158.89 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards];157.91 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards];148.42 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral];H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
P203, P264, P270, P280, P301+P316, P318, P321, P330, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 40 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
L - Antineoplastic and immunomodulating agents;L01 - Antineoplastic agents;L01B - Antimetabolites;L01BC - Pyrimidine analogues;L01BC04 - Carmofur
QL - Antineoplastic and immunomodulating agents;QL01 - Antineoplastic agents;QL01B - Antimetabolites;QL01BC - Pyrimidine analogues;QL01BC04 - Carmofur
BeschreibungCarmofur is an inhibitor of acid ceramidase (IC50 = 79 nM for the rat enzyme) and a derivative of 5-flurouracil . It reduces acid ceramidase activity in a dose- and time-dependent manner and induces intracellular accumulation of various ceramide species, including C18 ceramide , C16 ceramide , and C14 ceramide in SW403 colon and LNCaP prostate cancer cells. Carmofur induces apoptosis in SW403 cells without inhibiting DNA synthesis (IC50 = 1,212 mM for human thymidylate synthetase). It also reduces acid ceramidase activity and increases ceramide accumulation in mouse lung and brain when administered at doses of 10 and 30 mg/kg.
VerwendenCarmofur has been used as an inhibitor of acid ceramidase to study its effects on glucosylsphingosine (GlcSph) production in human embryonic kidney 293T (HEK293T) cells. It has also been used as an inhibitor of acid ceramidase to study its effects on acid‐mediated hydrolysis of ceramide which kicks-in consumption and the generation of sphingosine .
Wird geladen…