Chlorothiazid

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then dampen the solid spill material with toluene, then transfer the dampened material to a suitable container. Use absorbent paper dampened with toluene to pick up any remaining material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent-wash all contaminated surfaces with toluene followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

...IN DOG PRELOADED WITH SODIUM BICARBONATE, URINE EXCRETED AFTER ADMIN OF A THIAZIDE CONTAINS RELATIVELY MORE BICARBONATE THAN CHLORIDE. /BENZOTHIADIAZIDES/

USE OF ENTERIC-COATED COMBINATIONS OF POTASSIUM CHLORIDE & THIAZIDE... ASSOCIATED WITH A HIGH INCIDENCE OF ULCERATION OF DISTAL JEJUNUM OF ILEUM. /BENZOTHIADIAZIDES/

Concurrent use of thiazide diuretics with amiodarone may lead to an increased risk of arrhythmias associated with hypokalemia. /Thiazide diuretics/

Effects /of coumarin- or indandione-derivative anticoagulants/ may be decreased when used concurrently with thiazide diuretics as a result of reduction of plasma volume leading to concentration of procoagulant factors in the blood; in addition, diuretic-induced improvement of hepatic function resulting in increased procoagulant factor synthesis; dosage adjustments may be necessary. /Thiazide diuretics/

For more Interactions (Complete) data for CHLOROTHIAZIDE (16 total), please visit the HSDB record page.

TWO SMALL CHILDREN...INGESTED TOTAL DOSE OF 15 G CHLOROTHIAZIDE BETWEEN THEM, PRESENTED WITH LETHARGY WHICH PROGRESSED TO DEEP COMA WITHIN 12 HR. BOTH RECOVERED WITHOUT SEQUELAE, & NEITHER CHILDREN EXHIBITED OBJECTIVE EVIDENCE OF FLUID OR ELECTROLYTE DISORDER. ...22-MO-OLD CHILD WHO INGESTED 3 G EXHIBITED LETHARGY.

FETAL OR NEONATAL EFFECT IS THROMBOCYTOPENIA. /FROM TABLE/

Maternal and fetal deaths in two cases of acute hemorrhagic pancreatitis were attributed to the use of chlorothiazide in the second and third trimesters.

In addition to diuresis and resultant dehydration, overdosage of thiazides may produce lethargy, nausea, weakness, and electrolyte imbalance; lethargy may progress to coma within a few hours with minimal depression of respiratory and cardiovascular function and without evidence of dehydration or serum electryolye change. The mechanism of thiazide-induced CNS depression is unknown. GI irritation and hypermotility may occur, and temporary elevation of the BUN has been reported. Serum electrolyte changes (e.g., hypokalemia, hypochloremia, hyponatremia) may occur, especially in patients with impaired renal function. /Thiazides/

May suppress lactation, but compatible /SRP: with breast feeding/. /Thiazide diuretics, from table/

Drug Induced Liver Injury Rank (DILIrank 2.0)

Chlorothiazide

vLess-DILI-concern

2

Adverse reactions

DOI:10.1016/j.drudis.2016.02.015

DOSES OF UP TO 5 G/KG /IN MONKEYS/ BY GAVAGE PRODUCED ONLY A TRANSIENT LETHARGY OF A MODERATE DEGREE.

HYPOCHLOREMIA HAS OCCURRED IN SOME DOGS WITH INCR BICARBONATE RETENTION & ALKALOSIS.

LD50Rat oral 10 g/kg

LD50 Rat ip 1386 mg/kg

LD50 Rat iv 200 mg/kg

LD50 Mouse oral 8 g/kg

For more Non-Human Toxicity Values (Complete) data for CHLOROTHIAZIDE (7 total), please visit the HSDB record page.

Chlorothiazide

11.7

49.3

The usual adult dosage is 0.5 g to 1 g once or twice a day.

Data used to generate the benchmarks include the following: Lowest Daily Dose (LDD): 500 mg/day, Lowest Therapeutic Dose (LTD): 6.3 mg/kg-day, and Screening Dose: 0.002 mg/kg-day.

21-Jan-20

Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).

Diuretic /sodium salt/

MEDICATION (VET):

(1975) 7.5X10+6 GRAMS (PRINCPL CUSTMS DISTS)

(1976) 1.73X10+7 GRAMS (PRINCPL CUSTMS DISTS)

(1972) GREATER THAN 4.54X10+5 GRAMS

(1975) 4.54X10+5 GRAMS

REACTION OF 3-CHLOROANILINE WITH CHLOROSULFONIC ACID FOLLOWED BY TREATMENT WITH AMMONIA TO GIVE 3-CHLORO-4,6-DISULFONAMIDOANILINE WHICH IS THEN HEATED WITH FORMIC ACID

NOVELLO, SPRAGUE, J AM CHEM SOC 79, 2058 (1957); NOVELLO, HINKLEY, US PATENTS 2,809,194; 2,937,169 (1957, 1960, BOTH TO MERCK & CO).

Pharmaceuticals -> Diuretics -> Transformation products

Pharmaceuticals -> Animal Drugs -> Approved in Taiwan

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide: ACTIVE

A 3 DAY TREATMENT WITHDRAWAL PERIOD SHOULD BE OBSERVED TO AVOID UNTOWARD EFFECTS IN PEOPLE FROM CONSUMING MEAT & ESPECIALLY MILK FROM TREATED ANIMALS.