R-(+)-1-(1-Naphthyl)ethylamin

Beschreibung(R)-(+)-1-(1-Naphthyl)ethylamine is a reagent used in the formation of isolated acids via salt formation. It is also a raw material for the synthesis of (R)-1-(1-Naphthyl)ethyl isocyanate. In materials research, the use of Reflectance Absorption Infrared Spectroscopy (RAIRS) can be used to study the structure, bonding and orientation of R-1- nea and (S)-(-)-1-(2-naphthyl)ethylamine (S-2- nea) on Pd(1 1 1).

Verwenden(R)-(+)-1-(1-Naphthyl)ethylamine is a key intermediate in the synthesis of the chiral drug cinacalcet (trade name: Sensipar) and also an important intermediate in the synthesis of a coronavirus PLpro protease inhibitor. (R)-(+)-1-(1-Naphthyl)ethylamine and (S)-(-)-1-(1-naphthyl)ethylamine both belong to the class of chiral aromatic amine separators and have broad application prospects in fields such as chiral drugs and chiral pesticides.

synthetischeThere are three main methods for preparing (R)-(+)-1-(1-Naphthyl)ethylamine: (1) Enzymatic separation method; (2) Chemical separation method, with the following separation agents used: chiral aspartic acid, chiral α-hydroxy naphthoic acid, protective chiral glycerol derivatives, and chiral tartaric acid; (3) Dissymmetric synthesis, etc. Using dissymmetric synthesis as an example, obtain Chiral Amine to prochiral ketone oxime through asymmetric catalytic hydrogenation reduction, method adopts ammonium formiate to reduce by 1-(1-naphthyl) acetophenone oxime, at chlorine { [(1R, 2R)-(-)-2-ammonia-1,2-Diphenethyl] (4-tolylsulfonyl) ammonia (p-isopropyl toluene) ruthenium (II)) catalyzer exist under, adopt polar solvent as dimethyl formamide, methyl alcohol, ethanol, n-propyl alcohol, Virahol, butanols, the one in the trimethyl carbinol.Catalytic asymmetric reduction single step reaction preparation (R)-(+)-1-(1-naphthyl) ethamine is carried out to 1-(1-naphthyl) acetophenone oxime.