Diphenyleneiodonium chloride
Grundinformationen
- CAS
4673-26-1- Standard-SMILES
[Cl-].c1ccc2c(c1)[I+]c1ccccc1-2- InChIKey
FCFZKAVCDNTYID-UHFFFAOYSA-M- Summenformel
- C12H8ClI
- Durchschnittliche Molmasse
- 314,55 g/mol
- Monoisotopische Masse
- 313,93593
Überblick
Dibenziodolium chloride is an organic chloride salt having dibenziodolium as the counterion. It has a role as an EC 1.6.3.1. [NAD(P)H oxidase (H2O2-forming)] inhibitor and a G-protein-coupled receptor agonist. It contains a dibenziodolium.
Namen und Bezeichner
- Bevorzugter Name
- Diphenyleneiodonium chloride
- IUPAC
- 8-iodoniatricyclo[7.4.0.02,7]trideca-1(13),2,4,6,9,11-hexaene chloride
- Englischer Name
- Diphenyleneiodonium chloride
- Summenformel
- C12H8ClI
- Molmasse
- 314.55
Namen und Synonyme
Diphenyleneiodonium chlorideDibenziodolium chlorideUNII-7M9D81YZ2N7M9D81YZ2Ndibenzo[b,d]iodolium chlorideCHEBI:77967DTXSID001969322,2'-biphenylyleneiodonium chloridedibenzo(b,d)iodolium chlorideRefChem:134677DTXCID40119423805-298-3
Weitere Namen anzeigen
DPI (Diphenyleneiodonium chloride)ibenziodoliumchlorideDibenz[b,d]iodoliuM ChlorideDiphenyl iodine chloride saltDibenziodolium chloride, DPIDiphenyleneiodoniumchloride(DPI)
4673-26-1dibenzo[b,d]iodol-5-ium chlorideDPIMFCD002141658-iodoniatricyclo[7.4.0.02,7]trideca-1(13),2,4,6,9,11-hexaene;chloridediphenylene iodonium chlorideDPI chlorideCHEMBL397686
Datenbank-Bezeichner
- CAS
4673-26-1- PubChem CID
- 2733504
- DTXSID
DTXSID00196932- ChEMBL
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 0 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 1
- Frei drehbare Bindungen
- 0
- Schwere Atome
- 14
- Formalladung
- 0
- Komplexität
- 170
Physikochemische Eigenschaften
- Schmelzpunkt
- 312 · 312-322 °C
- storage temp.
- room temp
- Löslichkeit
- Soluble in DMSO (up to 5 mg/ml with warming)
- Aggregatzustand
- Powder
- Farbe
- Off-white
- Stabilität
- 1 year · Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
- InChI
- InChI=1S/C12H8I.ClH/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11;/h1-8H;1H/q+1;/p-1
- InChIKey
- FCFZKAVCDNTYID-UHFFFAOYSA-M
- SMILES
- [I+]1C2=C(C=CC=C2)C2=C1C=CC=C2.[Cl-]
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Gefahrenhinweise
Hazard Classes and CategoriesEye Irrit. 2 (100%)
Sicherheitsdaten
- wgk
- 3
- hs_code
- 29310099
- risk_code
- 36
- hazard_code
- Xi
- safety_code
- 26
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Anwendungen
BeschreibungDiphenyleneiodonium (DPI) is an inhibitor of NADPH oxidase (NOX; EC50 = 0.1 μM in HeLa cells). It also inhibits nitric oxide synthase (NOS; IC50 = 0.05 μM in isolated mouse peritoneal macrophages). DPI (10, 50, and 100 μM) induces the production of reactive oxygen species (ROS) in, and apoptosis of, human umbilical vein endothelial cells (HUVECs). It inhibits NETosis induced by phorbol 12-myristate 13-acetate (PMA; ) in isolated human neutrophils when used at a concentration of 10 μM. DPI (2 mg/kg) reduces tumor growth in HT-29 and LS 174T colon cancer mouse xenograft models.
Anbieter100 Anbieter
山东玖玥生物科技有限公司15553333686 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
湖南韵邦生物科技股份有限公司0731-88532326 13319508186 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
湖北万得化工有限公司15377098680 15377098680 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
咸宁深蓝生物医药研发有限公司18171815831 · [email protected]
湖北科乐精细化工有限公司027-59101668 19945030958 · [email protected]
Hebei Yanxi Chemical Co., Ltd.+86-17531190177 · [email protected]
上海迈瑞尔生化科技有限公司
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