N-Iminoethyl-L-lysine dihydrochloride
Grundinformationen
- CAS
159190-45-1- Standard-SMILES
CC(N)=NCCCC[C@H](N)C(=O)O.Cl.Cl- InChIKey
OQIBCXRAFAHXMM-KLXURFKVSA-N- Summenformel
- C8H19Cl2N3O2
- Durchschnittliche Molmasse
- 260,16 g/mol
- Monoisotopische Masse
- 259,0854322
Überblick
N(6)-acetimidoyl-L-lysine dihydrochloride is a hydrochloride salt prepared from N6-acetimidoyl-L-lysine and two equivalents of hydrogen chloride. A selective inhibitor of inducible nitric oxide synthase. It has a role as an EC 1.14.13.39 (nitric oxide synthase) inhibitor. It contains a N(6)-acetimidoyl-L-lysinium(2+).
Namen und Bezeichner
- Bevorzugter Name
- N-Iminoethyl-L-lysine dihydrochloride
- IUPAC
- (2S)-2-amino-6-(1-aminoethylideneamino)hexanoic acid;dihydrochloride
- Englischer Name
- L-N6-(1-Iminoethyl)lysine dihydrochloride
- Summenformel
- C8H18ClN3O2
- Molmasse
- 223.7
Namen und Synonyme
L-N6-(1-Iminoethyl)lysine dihydrochloride159190-45-1N-iminoethyl-L-lysine dihydrochloride8BL5V0T01YL-Lysine, N6-(1-iminoethyl)-, dihydrochlorideL-Lysine, N6-(1-iminoethyl)-, hydrochloride (1:2)DTXSID3040562RefChem:830152DTXCID1020562L-NIL dihydrochlorideL-NIL (dihydrochloride)L-NIL (hydrochloride)
Weitere Namen anzeigen
L-NIL HCLL-NIL 2HClL-N6-(1-Iminoethyl)lysineOQIBCXRAFAHXMM-KLXURFKVSA-NL-N6-(1-IMINOETHYL)-LYSINE 2HCLL-N6-(1-IMINOETHYL)LYSINE, DIHCLL-Lysine ω-acetamidine dihydrochlorideN6-(1-Iminoethyl)lysine dihydrochloride
UNII-8BL5V0T01YCHEMBL1744034(2S)-2-amino-6-(1-aminoethylideneamino)hexanoic acid;dihydrochlorideAKOS027320886N(6)-acetimidoyl-L-lysine dihydrochlorideL-N(6)-(1-iminoethyl)lysine dihydrochlorideSCHEMBL677147CHEBI:63964
Datenbank-Bezeichner
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 102 Ų
- H-Brücken-Donoren
- 5
- H-Brücken-Akzeptoren
- 4
- Frei drehbare Bindungen
- 6
- Schwere Atome
- 15
- Formalladung
- 0
- Komplexität
- 192
Physikochemische Eigenschaften
- storage temp.
- -20 °C · -20°C
- Löslichkeit
- 15 mg/mL; · DMF: 15 mg/mL; DMSO: 15 mg/mL; Ethanol: 1 mg/mL; PBS: 30 mg/mL; Water: 50 mg/ml
- Aggregatzustand
- White to off-white solid.
- Biologische Quelle
- synthetic (organic)
- Wasserlöslichkeit
- 50 mg/mL, · water: 50mg/mL, clear, colorless
- InChI
- 1S/C8H17N3O2.2ClH/c1-6(9)11-5-3-2-4-7(10)8(12)13;;/h7H,2-5,10H2,1H3,(H2,9,11)(H,12,13);2*1H/t7-;;/m0../s1
- InChIKey
- OQIBCXRAFAHXMM-KLXURFKVSA-N
- SMILES
- Cl.Cl.CC(=N)NCCCC[C@H](N)C(O)=O
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazard Classes and CategoriesSkin Irrit. 2 (100%)
Sicherheitsdaten
- wgk
- 3
- risk_code
- 36/37/38
- hazard_code
- Xi
- safety_code
- 37/39-26-36
- Speicherklasse
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2Skin Irrit. 2STOT SE 3
Chemie und Industrie
Anwendungen
BeschreibungL-NIL is a relatively selective inhibitor of iNOS. It exhibits IC50 values of 0.4-3.3 μM for iNOS as opposed to 8-38 and 17-92 μM for eNOS and nNOS, respectively. L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response to infection by the protozoan L. major.
VerwendenL-N6-(1-Iminoethyl)lysine dihydrochloride has been used as an inducible nitric oxide synthase (iNOS) inhibitor: to study its effects on leptin-induced modulation of fibronectin type III domain-containing five (FNDC5)/irisin in myocytes and fat cells of murineto study its effects on leptin-induced inflammation in hepatocytes to block the production of nitric oxide in mice bone marrow mesenchymal stromal cells (BMSCs)
Anbieter17 Anbieter
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
江苏艾康生物医药研发有限公司025-5885952 15955137747 · [email protected]
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司021-61415566 800-8193336 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
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