2-(Dicyclohexylphosphino)biphenyl
Cy-John-Phos · CYCLOHEXYL JOHNPHOS · (2-biphenyl)dicyclohexylphosphine · dicyclohexyl-(2-phenylphenyl)phosphane · biphenyl-2-yldicyclohexylphosphine · 2-(Dicyclo · 98% CyJohnPhos · CyJohnPhos 97%
Identifikatoren & physikalische Daten
| CAS No. | 247940-06-3 |
|---|---|
| Summenformel | C24H31P |
| Durchschnittliche Molmasse | 350,5 g/mol |
| Monoisotopische Masse | 350,21633799 g/mol |
| SMILES | c1ccc(-c2ccccc2P(C2CCCCC2)C2CCCCC2)cc1 |
| InChIKey | LCSNDSFWVKMJCT-UHFFFAOYSA-N |
| PubChem CID | 2734216 |
| EC No. | 480-030-2 |
| DTXSID | DTXSID60370170 |
Chemische & physikalische Eigenschaften
| XLogP | 6,7 |
|---|---|
| Polarare Oberfläche (TPSA) | 0 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 0 |
| Frei drehbare Bindungen | 4 |
| Schwere Atome | 25 |
| Formalladung | 0 |
| Komplexität | 356 |
| Schmelzpunkt | 102-106 °C(lit.) |
| Siedepunkt | 499.5±24.0 °C(Predicted) |
| Lagerbedingungen | under inert gas (nitrogen or Argon) at 2-8°C |
| Löslichkeit | soluble in Toluene |
| Aggregatzustand | crystal |
| Farbe | white |
| BRN | 8440533 |
| InChI | InChI=1S/C24H31P/c1-4-12-20(13-5-1)23-18-10-11-19-24(23)25(21-14-6-2-7-15-21)22-16-8-3-9-17-22/h1,4-5,10-13,18-19,21-22H,2-3,6-9,14-17H2 |
| InChIKey | LCSNDSFWVKMJCT-UHFFFAOYSA-N |
| SMILES | P(C1=CC=CC=C1C1=CC=CC=C1)(C1CCCCC1)C1CCCCC1 |
| CAS Datenbank | 247940-06-3(CAS DataBase Reference) |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH315 (13.3%): Causes skin irritation [Warning Skin corrosion/irritation]H319 (13.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]H335 (13.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposureRespiratory tract irritation]H413 (88.9%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]P261, P264, P264+P265, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 45 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| Regulatorische Informationen | Status: Active Update: 07-03-2012 https://echa.europa.eu/registration-dossier/-/registered-dossier/2550 |
| Hazard Classes and Categories | Skin Irrit. 2 (13.3%)Eye Irrit. 2 (13.3%)STOT SE 3 (13.3%)Aquatic Chronic 4 (88.9%)Skin Irrit. 2 (100%)Eye Irrit. 2A (100%)STOT SE 3 (100%)Aquatic Chronic 4 (100%) |
| F | 10-13-23 |
| Wassergefährdungsklasse (WGK) | 3 |
| TSCA-Inventar-Status | No |
| Zollcode | 29310099 |
| R-Sätze (R) | 36/37/38-22 |
| Gefahrensymbole | Xn |
| Sicherheitshinweise (S) | 36/37/39-26 |
| Gefahrenklasse | AIR SENSITIVEAquatic Chronic 4 |
| Lagerklasse | 11 - Combustible Solids |
Anwendungen & Verwendung
Beschreibung
2-(Dicyclohexylphosphino)biphenyl is a ligand for the amination of triflates and aryl halides. Optimal ligand for a novel amination reaction (Buchwald reaction)(2) 2-(Dicyclohexylphosphino)biphenyl, a synthetic chemical compound, has found diverse applications in scientific research. Being a cyclic phosphonate derivative of cyclohexanol, this colourless, odourless, and tasteless solid holds a distinct appeal for laboratory use. In scientific research, 2-(Dicyclohexylphosphino)biphenyl has proven invaluable. It serves as an excellent model compound for delving into protein-ligand interactions, thus aiding in studying small molecule effects on protein folding. Moreover, researchers have utilized 2-(Dicyclohexylphosphino)biphenyl to gain insights into protein structures and unravel the mechanism of action behind various drugs. Additionally, the compound has been a vital tool in assessing how environmental factors influence protein structure and function. The interaction between 2-(Dicyclohexylphosphino)biphenyl and proteins primarily occurs through hydrogen bonding and hydrophobic interactions, resulting in high-affinity and specific protein binding.
Verwenden
2-(Dicyclohexylphosphino)biphenyl is used as a catalyst for Suzuki coupling reactions.