Zinkcyanid

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

General First Aid:

· Wear positive pressure self-contained breathing apparatus (SCBA).

2.0 [mg/m3], inhalable fraction, as CN[German Research Foundation (DFG)]

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use foam, dry chemical, or carbon dioxide. Do not use water on material itself. If large quantities of combustibles are involved, use water in flooding quantities as spray and fog. Use water spray to knock-down vapors.

Carbon dioxide fire extinguishers must not be used where cyanide salts are present. /Cyanide salts/

ALL CONTAINERS OF CYANIDE SALTS SHOULD BE KEPT COVERED OR IN EXHAUST HOOD WHEN NOT IN USE. /CYANIDES/

Cyanide salts as solids must be stored in sealed or tightly closed containers. No hooks should be used in handling cyanide containers. ... Storage areas must be adequately ventilated to ensure that cyanide concentrations do not exceed the recommended workplace environmental limits. /Cyanide salts/

Cyanide salts as solids or solutions must be ... protected from corrosion or damage. They should be stored so there is no contact with nitrate-nitrite mixtures or peroxides. /Cyanide salts/

... SHOULD BE STORED IN COOL, WELL-VENTILATED PLACE, OUT OF DIRECT RAYS OF SUN, AWAY FROM ... FIRE HAZARD, & SHOULD BE PERIODICALLY INSPECTED & MONITORED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED ... /CYANIDES & COPPER CMPD/

REMOVAL AND RECOVERY OF CYANIDE AND ZINC FROM ELECTROPLATING WASTES BY SOLVENT EXTRACTION.

AN IMPROVED ION-EXCHANGE RESIN METHOD FOR REMOVAL AND RECOVERY OF ZINC CYANIDE AND CYANIDE FROM ELECTROPLATING WASTES.

Land spill: Dig a pit, pond, lagoon, or holding area to contain liquid or solid material /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water.

Environmental considerations - Water spill: Neutralize with agricultural lime (calcium oxide), crushed limestone (calcium carbonate), or sodium bicarbonate. Add calcium hypochlorite. Adjust pH to neutral (pH 7). Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates.

For more Cleanup Methods (Complete) data for ZINC CYANIDE (7 total), please visit the HSDB record page.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number P121; D003, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

Zinc cyanide is a poor candidate for incineration.

Cyanide salts should not be flushed into any drain which may contain or subsequently receive acid waste. ... Cyanide process waste solutions and flushings from spills should be passed through a cyanide waste disposal system. /Cyanide salts/

The proprietary Sulfex process (Permutit Co) has been applied to zinc wastes. The process involves addition of ferrous sulfide, which gradually releases sulfide to precipitate the zinc ... . /Zinc/

For more Disposal Methods (Complete) data for ZINC CYANIDE (6 total), please visit the HSDB record page.

ALL CONTAINERS ... SHOULD BE KEPT COVERED OR IN EXHAUSTED HOOD WHEN NOT IN USE. ANY PROCESS THAT MAY RELEASE HYDROGEN CYANIDE SHOULD BE MECHANICALLY EXHAUSTED, WITH PROVISION FOR HIGHER RATE DURING EMERGENCIES. DIRECT READING INSTRUMENTS FOR DETERMINATION OF HYDROCYANIC ACID ARE AVAILABLE. /CYANIDES/

PERSONS WHO WORK WITH & AROUND CYANIDE PREPN SHOULD BE GIVEN SPECIFIC DETAILED INSTRUCTIONS ON MANAGEMENT OF CYANIDE POISONING. /CYANIDE/

Eyewash facilities and emergency showers shall be provided in areas where contact with ... cyanide salts as either solids or solutions is likely. Work clothing which has been contaminated by absorption of, or contact with, cyanide shall be thoroughly laundered before it is worn again. /Hydrogen cyanide and cyanide salts/

If the clothing is to be laundered or otherwise cleaned to remove the cyanide, the person performing the operation should be informed of cyanide's hazardous properties. /Cyanides/

For more Preventive Measures (Complete) data for ZINC CYANIDE (12 total), please visit the HSDB record page.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

Immediate precautionary measure

Zinc poisoning is treated symptomatically, often by administering fluids such as water or milk, or with gastric lavage. Antidotes to cyanide poisoning include hydroxocobalamin and sodium nitrite, which release the cyanide from the cytochrome system, and rhodanase, which is an enzyme occurring naturally in mammals that combines serum cyanide with thiosulfate, producing comparatively harmless thiocyanate. Oxygen therapy can also be administered. (L49, L97)

Chronic exposure to zinc causes anemia, atazia, lethargy, and decreases the level of good cholesterol in the body. It is also believed to cause pancreatic and reproductive damage. Exposure to high levels of cyanide for a short time harms the brain and heart and can even cause coma, seizures, apnea, cardiac arrest and death. Chronic inhalation of cyanide causes breathing difficulties, chest pain, vomiting, blood changes, headaches, and enlargement of the thyroid gland. Skin contact with cyanide salts can irritate and produce sores. (L49, L96, L97)

Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxic cyanide ions or hydrogen cyanide. Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. Cyanide is also known produce some of its toxic effects by binding to catalase, glutathione peroxidase, methemoglobin, hydroxocobalamin, phosphatase, tyrosinase, ascorbic acid oxidase, xanthine oxidase, succinic dehydrogenase, and Cu/Zn superoxide dismutase. Cyanide binds to the ferric ion of methemoglobin to form inactive cyanmethemoglobin. (L48, L49, A49, L97)

Ingestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. Cyanide poisoning is identified by rapid, deep breathing and shortness of breath, general weakness, giddiness, headaches, vertigo, confusion, convulsions/seizures and eventually loss of consciousness. (L49, L96, L97)

Zinc cyanide

Endocrine

5 x 10 ^-2 mg/kg-day

Initial medical examination /should include/: a complete history and physical examination ... to detect existing conditions that might place the exposed employee at incr risk & to establish a baseline for future health monitoring. ... Examination of cardiovascular, nervous, & upper resp systems, & thyroid should be stressed. The skin should be exam for evidence of chronic disorders. ... The aforementioned medical exam should be repeated on an annual basis. ... /Cyanides/

Pre-placement and periodic examinations should include the cardiovascular and central nervous systems, liver and kidney function, blood, history of fainting and dizzy spells. Blood cyanide levels may be useful during acute intoxication. Urinary thiocyanate levels have been used but are nonspecific and are elevated in smokers. /Cyanide/

Arterial Blood Gases: Arterial blood gases may be useful for monitoring of metabolic acidosis that can occur from cyanide poisoning. /Cyanide/

EKG Measurement: EKG monitoring may be useful since changes have been found with cyanide exposure. /Cyanide/

For more Medical Surveillance (Complete) data for ZINC CYANIDE (11 total), please visit the HSDB record page.

Zinc cyanide ... may cause dermatitis.

SYMPTOMATOLOGY: 1. Massive doses may produce, without warning, sudden loss of consciousness and prompt death from respiratory arrest. With smaller but still lethal doses, the illness may be prolonged for 1 or more hours. 2. Upon ingestion, a bitter, acrid, burning taste is sometimes noted, followed by a feeling of constriction or numbness in the throat. Salivation, nausea and vomiting are not unusual ... 3. Anxiety, confusion, vertigo, giddiness, and often a sensation of stiffness in the lower jaw. 4. Hyperpnea and dyspnea. Respirations become very rapid and then slow and irregular. Inspiration is characteristically short while expiration is greatly prolonged. 5. The odor of bitter almonds may be noted on the breath or vomitus ... 6. In the early phases of poisoning, an increase in vasoconstrictor tone causes a rise in blood pressure and reflex slowing of the heart rate. Thereafter the pulse becomes rapid, weak, and sometimes irregular. ... A bright pink coloration of the skin due to high concentrations of oxyhemoglobin in the venous return may be confused with that of carbon monoxide poisoning. /Cyanides/

SYMPTOMATOLOGY: 7. Unconsciousness, followed promptly by violent convulsions, epileptiform, or tonic, sometimes localized but usually generalized. Opisthotonos and trismus may develop. Involuntary micturition and defecation occur. 8. Paralysis follows the convulsive stage. The skin is covered with sweat. The eyeballs protrude, and the pupils are dilated and unreactive. The mouth is covered with foam, which is sometimes bloodstained. ... The skin color may be brick red. Cyanosis is not prominent in spite of weak and irregular gasping. In the unconscious patient, bradycardia and the absence of cyanosis may be key diagnostic signs. 9. Death from respiratory arrest. As long as the heart beat continues, prompt and vigorous treatment offers some promise of survival. /Cyanide/

MOST SPECIFIC PATHOLOGICAL FINDING IN ACUTE CASES /OF CYANIDE POISONING/ IS BRIGHT RED COLOR OF VENOUS BLOOD. THIS IS STRIKING, VISIBLE EVIDENCE OF INABILITY OF TISSUE CELLS TO UTILIZE OXYGEN ... VENOUS BLOOD IS ONLY ABOUT 1 VOL % LOWER IN OXYGEN CONTENT THAN ARTERIAL BLOOD ... /CYANIDES/

For more Human Toxicity Excerpts (Complete) data for ZINC CYANIDE (18 total), please visit the HSDB record page.

P121; As stipulated in 40 CFR 261.33, when zinc cyanide, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to federal and/or state hazardous waste regulations. Also defined as a hazardous waste is any container or inner liner used to hold this waste or any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5(e)).

/SRP:/ D003; A solid waste containing zinc cyanide may become characterized as a hazardous waste when subjected to testing for reactivity as stipulated in 40 CFR 261.23, and if so characterized, must be managed as a hazardous waste.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 10 lb or 4.54 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

Zinc cyanide is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance.

Toxic pollutant designated pursuant to section 307(a)(1) of the Clean Water Act and is subject to effluent limitations. /Cyanides; zinc and cmpd/

(CA) CALIFORNIA 150 ug/L /Cyanide ion/

(IL) ILLINOIS 5000 ug/l /Zinc/

(AZ) ARIZONA 5000 ug/l /Zinc/

(MN) MINNESOTA 2000 ug/l /Zinc/

Used in chemical analysis, electroplating, gold extraction, and removing ammonia from producer gas; [HSDB] Used to make phthalocyanine dyes; [Ullmann]

Electroplating [Category: Plate]

Metal plating; chemical reagent; in insecticide

Electroplating; removing ammonia from producer gas

IN GOLD EXTRACTION

Zinc cyanide is used in organic synthesis. (L65)

(1984) 1.50X10+8 g

(1986) 2.70X10+5 lb

Grade: Technical

Usually contains about 85% zinc cyanide, some water and oxide