Potassium Citrate

This chemical does not meet GHS hazard criteria for 100% (181 of 181) of all reports.

Not Classified；Reported as not meeting GHS hazard criteria by 181 of 181 companies. For more detailed information, please visit ECHA C&L website.

Aggregated GHS information provided per 181 reports by companies from 2 notifications to the ECHA C&L Inventory.；Reported as not meeting GHS hazard criteria per 181 of 181 reports by companies.；There are 0 notifications provided by 0 of 181 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Not Classified；Reported as not meeting GHS hazard criteria by 1 of 1 companies. For more detailed information, please visit ECHA C&L website.

Chemical: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt, monohydrate

Tripotassium citrate monohydrate: Does not have an individual approval but may be used under an appropriate group standard

Not Classified

Not Classified

2.1 [mg/m3]

23 [mg/m3]

140 [mg/m3]

2.2 [mg/m3]

24 [mg/m3]

150 [mg/m3]

Chemical: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt, monohydrate

Tripotassium citrate monohydrate: Does not have an individual approval but may be used under an appropriate group standard

A - Alimentary tract and metabolism；A12 - Mineral supplements；A12B - Potassium；A12BA - Potassium；A12BA02 - Potassium citrate

QA - Alimentary tract and metabolism；QA12 - Mineral supplements；QA12B - Potassium；QA12BA - Potassium；QA12BA02 - Potassium citrate

Potassium citrate induces changes in the urine which renders urine less susceptible to the formation of crystals and stones from salts e.g. calcium oxalate, calcium phosphate and uric acid. Increased citrate levels in the urine will make complexation with calcium which decrease the calcium ion activity and decrease the chance for the formation of calcium phosphate crystals. Citrate also inhibits the spontaneous nucleation of calcium oxalate and calcium phosphate.

After oral administration of potassium citrate, its metabolism yields alkaline load. Potassium Citrate therapy appears to increase urinary citrate mainly by modifying the renal handling of citrate, rather than by increasing the filtered load of citrate. In addition to raising urinary pH and citrate, Potassium Citrate increases urinary potassium by approximately the amount contained in the medication. In some patients, Potassium Citrate causes a transient reduction in urinary calcium.

KALI CITRICUM

Calcium Chelating Activity [MoA]; Decreased Coagulation Factor Activity [PE]; Calculi Dissolution Agent [EPC]; Acidifying Activity [MoA]; Anti-coagulant [EPC]

POTASSIUM CITRATE

Calculi Dissolution Agent [EPC]; Calcium Chelating Activity [MoA]; Decreased Coagulation Factor Activity [PE]; Acidifying Activity [MoA]; Anti-coagulant [EPC]

Agents that promote the excretion of urine through their effects on kidney function.

Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here.

CIR ingredient: Potassium Citrate

Used in food (sequestrant, emulsifier, and stabilizer) and in medicine as an alkalinizing agent and antiurolithic; [Merck Index] Used as a flavoring agent, nutritional supplement, pH control agent, and sequestrant for foods; [FDA]

Information on 2 consumer products that contain Potassium Citrate in the following categories is provided:；• Commercial / Institutional

Information on 29 consumer products that contain Potassium Citrate in the following categories is provided:；• Auto Products；• Commercial / Institutional；• Inside the Home

EPA Safer Chemical Functional Use Classes -> Chelating Agents;Processing Aids and Additives

Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Food Additives -> ACIDITY_REGULATOR; SEQUESTRANT; STABILIZER -> JECFA Functional Classes