HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HCID 27520Erstellt: 26. Oktober 2026
2,4-Diamino-6-methylphenol
2,4-Diamino-6-methylphenol · Phenol, 2,4-diamino-6-methyl-
https://huagongshe.com/de/chemical/27520
Identifikatoren & physikalische Daten
| CAS No. | 15872-73-8 |
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| Summenformel | C7H10N2O |
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| Durchschnittliche Molmasse | 138,17 g/mol |
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| Monoisotopische Masse | 138,07931295 g/mol |
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| SMILES | Cc1cc(N)cc(N)c1O |
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| InChIKey | WSVFDPKNANXQKM-UHFFFAOYSA-N |
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| PubChem CID | 27520 |
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| DTXSID | DTXSID2065963 |
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Chemische & physikalische Eigenschaften
| XLogP | 0,6 |
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| Polarare Oberfläche (TPSA) | 72,3 |
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| H-Brücken-Donoren | 3 |
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| H-Brücken-Akzeptoren | 3 |
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| Frei drehbare Bindungen | 0 |
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| Schwere Atome | 10 |
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| Formalladung | 0 |
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| Komplexität | 118 |
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| Stoffklassen | Nitrogen Compounds -> Amino Phenols |
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| EPA chemische Informationen | 4,6-Diamino-o-cresol (15872-73-8) |
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Sicherheit & Vorschriften
| Gefahrenübersicht | Emergency treatment: Phenol and related agentsIntraperitoneal administration of 33 mg/kg caused lethal methemoglobinemia within 15-20 minutes in animal experiments[HSDB] |
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| Special Reports | REVIEW:[UNITED STATES EPAPHENYLENEDIAMINESRESPONSE TO INTERAGENCY TESTING COMMITTEEFED REGIST 47(5) 973 (1982)] |
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| Unerwünschte Wirkungen | Methemoglobinemia - The presence of increased methemoglobin in the bloodthe compound is classified as secondary toxic effect |
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| Non-Human Toxicity Excerpts | THE IP ADMIN OF 4,6-DIAMINO-O-CRESOL (33 MG/KG) OR 4,6-DIAMINO-2-SEC-BUTYLPHENOL (43 MG/KG) PRODUCED A LETHAL METHEMOGLOBINEMIA WITHIN 15-20 MINUTES. THE INTRARUMINAL ADMIN INDUCED A LESS DRAMATIC METHEMOGLOBINEMIA. HEMOLYSIS & ACUTE NEPHROSIS WERE OBSERVED IN A PROLONGED EXPERIMENT. APPARENTLY, THE DIAMINOPHENOL METABOLITES ARE RESPONSIBLE FOR THE METHEMOGLOBIN FORMATION IN DINITROPHENOL (DNOC OR DNBP) POISONINGS.2-METHYL-4,6-DINITROPHENOL SHOWED HIGHER TOXICITY TO SHEEP THAN 2-(1-METHYLPROPYL)-4,6-DINITROPHENOL FOLLOWING ORAL ADMIN (70 MG/KG)HOWEVER, DYSPNEA & HYPERTHERMIA WERE CAUSED BY THEIR RESPECTIVE DIAMINO METABOLITES, 2-METHYL-4,6-DIAMINOPHENOL & 2-(1-METHYLPROPYL)-4,6-DIAMINOPHENOL. THE METABOLITES ALSO CAUSED METHEMOGLOBINEMIA, HYPOTHERMIA, & HEMOCONCENTRATION.Diamino metabolites of DNOC ... were active inducers of methemoglobin formation in vitro at a concentration of 5 x 10-4 M. Marked hemoglobinemia was observed almost immediately in a goat given an intraperitoneal injection of 2-methyl-4,6-diamino phenol (DAOC) at 33 mg free amine/kg, and the goat died within 45 min. A slower and less pronounced development of methemoglobinemia developed following ruminal administration of the same dose of DAOC. Hemoconcentration was observed in both cases, and hemolysis and nephrotic lesions were found in the latter. Intraperitoneal administration of both compounds to pigs produced immediate methemoglobinemia and death within 1 hr. The results confirm the hypothesis that methemoglobinemia following dinitrophenol poisoning in ruminants may be due to the diaminophenol metabolites. |
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| TSCA-Inventar-Status | TSCA listed |
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| Gefahrstoffdaten | 15872-73-8(Hazardous Substances Data) |
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