3-Hydroxyazetidine hydrochloride

HCID 2759290CAS 18621-18-6
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Grundinformationen

Standard-SMILES
Cl.OC1CNC1
InChIKey
UQUPQEUNHVVNKW-UHFFFAOYSA-N
Summenformel
C3H8ClNO
Durchschnittliche Molmasse
109,55 g/mol
Monoisotopische Masse
109,02944156

Namen und Bezeichner

Bevorzugter Name
3-Hydroxyazetidine hydrochloride
IUPAC
azetidin-3-ol;hydrochloride
Englischer Name
3-Hydroxyazetidine hydrochloride
Summenformel
C3H8ClNO
Molmasse
109.55

Namen und Synonyme

3-Hydroxyazetidine hydrochloride18621-18-6DTXSID30374721RefChem:94255DTXCID10325751628-004-3Azetidin-3-ol Hydrochlorideazetidin-3-ol hcl3-Hydroxyazetidine HClazetidin-3-ol hydrochloride saltMFCD02683887azetidin-3-ol;hydrochloride
Weitere Namen anzeigen
Azetidin-3-ol hydrochloride, 3-Hydroxyazetane hydrochlorideAZETAN-2-ONEBUTTPARK 75\04-67Azetidine-3-ol.HclBaricitinib-009-HCl3-hydroxyazatidine HCl3-Hydroxyl-azetidine HCl
3-Azetidinol HydrochlorideAzetidin-3-ol (hydrochloride)azetidine-3-ol hydrochloride3-hydroxyazetidinium chlorideazetidin-3-ol, hydrochloride3-hydroxy-azetidinium chlorideazetidin-3-ol monohydrochloride3-hydroxy azetidine hydrochloride

Datenbank-Bezeichner

CAS
18621-18-6
PubChem CID
2759290
DTXSID
DTXSID30374721
EC Number
628-004-3

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
32,3 Ų
H-Brücken-Donoren
3
H-Brücken-Akzeptoren
2
Frei drehbare Bindungen
0
Schwere Atome
6

Physikochemische Eigenschaften

Schmelzpunkt
85 · 85-90 °C
storage temp.
Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Aggregatzustand
Solid
Farbe
White to Off-White
Wasserlöslichkeit
Soluble in water, DMSO, methanol.

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 5 Einträge

This chemical does not meet GHS hazard criteria for 1.9% (1 of 52) of reports.

Danger

H302 (84.6%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 52 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Hazard Classes and CategoriesAcute Tox. 4 (84.6%)

Sicherheitsdaten

wgk
3
ridadr
UN1759
hs_code
29339900
risk_code
36/37/38-41-37/38-22
hazard_code
C,Xi,Xn
hazard_note
Harmful/Corrosive

Chemie und Industrie

Anwendungen · 1 Eintrag

Beschreibung3-hydroxyazaecyclobutane hydrochloride is an azaecyclobutane compound that is an important intermediate in the synthesis of Brectinib, which is obtained through a multi-step reaction. Brectinib was approved by the European Union. The monotherapy or in combination with methotrexate for the treatment of adult patients with moderate to severe active rheumatoid arthritis with inadequate or intolerant relief from one or more antirheumatic drugs. It is also the first JAK inhibitor approved in the European Union for the treatment of rheumatoid arthritis.

Vor- und nachgelagerte Produkte

Anbieter50 Anbieter

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海恩氟佳科技有限公司15800445152 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
INTATRADE GmbH+49 3493/605464 · [email protected]
T&W GROUP021-61551611 13296011611 · [email protected]

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