N,N-dimethylhydroxylamine hydrochloride
DIMETHYLHYDROXYLAMINEHYDROCHLORIDE · N,N-Dimethylhydroxylamine hydrochloride · N-hydroxy-N,N-dimethylamine hydrochloride · N,N-Dimethylhydroxylamine hydrochloride 99% · Methanamine,N-hydroxy-N-methyl-, hydrochloride (9CI)
Identifikatoren & physikalische Daten
| CAS No. | 16645-06-0 |
|---|---|
| Summenformel | C2H7NO.ClH |
| Durchschnittliche Molmasse | 97,54 g/mol |
| Monoisotopische Masse | 97,02944156 g/mol |
| SMILES | CN(C)O.Cl |
| InChIKey | HWWVAHCWJLGKLW-UHFFFAOYSA-N |
| PubChem CID | 27969 |
| EC No. | 240-691-8 |
| DTXSID | DTXSID30168107 |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 23,5 |
|---|---|
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 5 |
| Formalladung | 0 |
| Komplexität | 13,5 |
| Stoffklassen | Nitrogen Compounds -> Hydroxylamines |
| Dampfdruck | 21.2 [mmHg] |
| Physical Description | Light yellow hygroscopic crystals[Sigma-Aldrich MSDS] |
| Schmelzpunkt | 107-109 °C (lit.) |
| Aggregatzustand | solid |
| BRN | 3905683 |
| InChI | InChI=1S/C2H7NO.ClH/c1-3(2)4/h4H,1-2H31H |
| InChIKey | HWWVAHCWJLGKLW-UHFFFAOYSA-N |
| SMILES | N(O)(C)C.Cl |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement)Aggregated GHS information provided per 39 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatorische Informationen | Chemical: Methanamine, N-hydroxy-N-methyl-, hydrochloride |
| Gefahrenübersicht | An irritant[Sigma-Aldrich MSDS] |
| Hazard Classes and Categories | Skin Irrit. 2 (100%) |
| F | 3 |
| Wassergefährdungsklasse (WGK) | 3 |
| R-Sätze (R) | 36/38 |
| Gefahrensymbole | Xi |
| Sicherheitshinweise (S) | 26-36 |
| Lagerklasse | 11 - Combustible Solids |
| Gefahrenklasse | Eye Irrit. 2Skin Irrit. 2 |
Anwendungen & Verwendung
Verwenden
N,N-Dimethylhydroxylamine hydrochloride was used in the synthesis of 4,4-dimethyl-2,5,5-triphenyl-l.3-dioxa-4-azonia-2-bora-5-boratacyclopentane. It was also used as a polymer-chain terminator.
Herstellung & Synthese
synthetische
(a) Preparation of N,N-Dimethyl~(a-phenylethyl)amine Oxide. To a flask containing 11.0 g (0.074 mole) of N,N-dimethyl(a-phenylethyl)amine is added dropwise 18.3 g (0.19 mole) of 35% aqueous hydrogen peroxide, and the mixture is stirred for 11 hr at room temperature. The excess hydrogen peroxide is decomposed by stirring the mixture with 8 sqcm2 clean platinum foil until the evolution of oxygen ceases. Most of the water is removed by distillation at 35 mm Hg, at a bath temperature of 45-55°C. The material that condenses in the dry-ice trichloroethylene trap is saved for recovery in Procedure (b). The residual syrup is diluted with 25 ml of absolute ethanol, and the process is repeated twice while a capillary nitrogen ebulliator is used. The resulting amine oxide is a viscous syrup and has a slight odor of styrene. (b) Decomposition of N,N-Dimethyl-(a-phenylethyl)amine Oxide to Ν,Ν-Dimethylhydroxylamine. A 100 ml round bottom flask equipped with a capillary nitrogen inlet, and containing the preceding amine oxide is connected by a large-diameter tube to a condenser set for distillation with two receivers. Each receiver is cooled in a mixture of dry ice and trichloroethylene. The system is evacuated to 5 mm, and the flask is immersed in an oil bath at 85°C. The bath temperature is raised slowly to 115°C over a 35-min period, in which time most of the material distilled over. The bath temperature is finally raised to 150°C, in order to complete the (decomposition) distillation process. The residue remaining averages 0.35 g. The distillate in the dry-ice trap here and from Procedure (a) are combined, pentane is added as a solvent, and the mixture is washed with dilute hydrochloric acid. The acid solution is extracted with pentane, the latter washed with water until neutral. The product is obtained from the combined aqueous layers containing hydrochloric acid by concentration under reduced pressure, to give a crystalline residue. The latter, upon drying in a vacuum desiccator over P2O5 averages 6.73 g (94% yield), m.p. 101-101°C (sealed capillary). Recrys-tallization several times from a mixture of absolute ethanol and ether gives white, hygroscopic needles, m.p. 106.5-109°C (sealed capillary).