SRPK inhibitor

HCID 2797577CAS 218156-96-8

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Grundinformationen

Standard-SMILES: O=C(Nc1cc(C(F)(F)F)ccc1N1CCCCC1)c1ccncc1
InChIKey: DWFGGOFPIISJIT-UHFFFAOYSA-N
Summenformel: C18H18F3N3O
Durchschnittliche Molmasse: 349,35 g/mol

Namen und Bezeichner

Bevorzugter Name: SRPK inhibitor
Englischer Name: SRPK inhibitor
Summenformel: C18H18F3N3O
Molmasse: 349.35

Namen und Synonyme

CS-910SRPIN340SRPIN 340SRPIN-340SRPK inhibitorSRPIN340, >=98%SRPIN340 >=98% (HPLC)SRPIN340, 10 mM in DMSOSRPK Inhibitor(SRPIN340)SRPIN340 (SRPK inhibitor)

Datenbank-Bezeichner

CAS: 218156-96-8
PubChem CID: 2797577
ChEMBL: CHEMBL4064277
UNII: 9QS4MR9N9D
EC Number: 808-979-3
Nikkaji: J2.385.677H

Eigenschaften

Physikochemische Eigenschaften

Siedepunkt: 395.9 · 395.9±42.0 °C(Predicted)
Dichte: 1.306 · 1.306±0.06 g/cm3(Predicted)
storage temp.: 2 · 2-8°C
Löslichkeit: 20 mg/mL, · DMSO: soluble20mg/mL, clear
Aggregatzustand: powder
pka: 11.09 · 11.09±0.70(Predicted)
Farbe: white to beige
Stabilität: 1 year · Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChI: 1S/C18H18F3N3O/c19-18(20,21)14-4-5-16(24-10-2-1-3-11-24)15(12-14)23-17(25)13-6-8-22-9-7-13/h4-9,12H,1-3,10-11H2,(H,23,25)
InChIKey: DWFGGOFPIISJIT-UHFFFAOYSA-N
SMILES: O=C(C1=CC=NC=C1)NC2=C(N3CCCCC3)C=CC(C(F)(F)F)=C2

Sicherheit und Regulatorisches

Sicherheitsdaten

wgk: 3
risk_code: 22
hazard_code: Xn
Speicherklasse: 11 - Combustible Solids

Chemie und Industrie

Anwendungen · 2 Einträge

BeschreibungSerine/arginine-rich protein kinase 1 (SRPK1) targets proteins that contain multiple serine/arginine (SR) dipeptides, including SR-rich splicing factor 1, SRSF1. SRPIN340 is an isonicotinamide compound that inhibits SRPK1 (Ki = 0.89 μM). It is about 10-fold less effective against SRPK2 and does not inhibit the related SRPKs, Clk1 and Clk4. SRPIN340 suppresses the propagation of Sindbis virus in Vero cells and the replication of hepatitis C virus in Huh7/Rep-Feo-2a cells. By blocking SRPK1-mediated phosphorylation of SRSF1, SRPIN340 modulates alternative splicing of VEGF, reducing neovascularization both in cells and in animals.

VerwendenSRPIN340 is a SRPK1 kinase inhibitor, which shows potential novel targeted therapeutic strategy in prostate cancer.