Kartogenin
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Grundinformationen
- CAS
4727-31-5- Standard-SMILES
O=C(O)c1ccccc1C(=O)Nc1ccc(-c2ccccc2)cc1- InChIKey
SLUINPGXGFUMLL-UHFFFAOYSA-N- Summenformel
- C20H15NO3
- Durchschnittliche Molmasse
- 317,344 g/mol
- Monoisotopische Masse
- 317,10519334
Namen und Bezeichner
- Bevorzugter Name
- Kartogenin
- IUPAC
- 2-[([1,1'-Biphenyl]-4-yl)carbamoyl]benzoic acid
- Englischer Name
- KGN
- Summenformel
- C20H15NO3
- Molmasse
- 317.34
Namen und Synonyme
KartogeninKartogenin(KGN)Benzoic acid, 2-[([1,1'-biphenyl]-4-ylamino)carbonyl]-KGNCS-612100822KGN USP/EP/BPKGN Cells LineKGN，KartogeninKartogenin, 10 mM in DMSO
Datenbank-Bezeichner
- CAS
4727-31-5- PubChem CID
- 2826191
- DTXSID
DTXSID30385074- ChEMBL
CHEMBL3185782- UNII
- Q93BBN11CP
- EC Number
- 803-978-4
- Nikkaji
- J3.342.662C
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 272 °C · 272 °C
- Siedepunkt
- 464.4 · 464.4±38.0 °C(Predicted)
- Dichte
- 1.289 · 1.289±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- Löslichkeit
- 15 mg/mL · DMSO: >15mg/mL
- Aggregatzustand
- powder
- pka
- 3.45 · 3.45±0.36(Predicted)
- Farbe
- White
- Stabilität
- 1 year · Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
- InChI
- 1S/C20H15NO3/c22-19(17-8-4-5-9-18(17)20(23)24)21-16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24)
- InChIKey
- SLUINPGXGFUMLL-UHFFFAOYSA-N
- SMILES
- O=C(NC1=CC=C(C2=CC=CC=C2)C=C1)C(C=CC=C3)=C3C(O)=O
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- ridadr
- UN 3077 9 / PGIII
- hs_code
- 2916310090
- risk_code
- 22-36-50/53
- hazard_code
- Xn,N
- safety_code
- 60-61
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Anwendungen
BeschreibungKartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes with an EC50 value of 100 nM. Kartogenin induces chondrogenesis by binding the actin-binding protein, filamin A, which disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ). When dissociated from filamin A, CBFβ translocates to the nucleus and forms a transcriptional complex with the runt-related transcription factor RUNX1, which enables chondrocyte differentiation. Kartogenin has been shown to promote cartilage repair in a mouse model of osteoarthritis and to protect against cytokine-induced damage in osteoarthritic bovine articular chondrocytes in vitro.
VerwendenKartogenin is a potent, selective, and non-cytotoxic downstream RUNX1 and RUNX2 modulator. Kartogenin causes mesenchymal stem cells found in joints to differentiate into chondrocyte cells that can build cartilage where it has been destroyed.
Anbieter100 Anbieter
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
上海康朗生物科技有限公司021-61998208 18217752821 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
武汉尚恩生物技术有限公司17764018385 · [email protected]
上海冬洋生物科技有限公司0512-13601744364 13601744364 · [email protected]
江苏星科元信息科技有限公司
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