1-Anilino-3-(3,6-dibromo-9H-carbazol-9-yl)-2-propanol

BeschreibungP7C3 is an orally bioavailable and brain penetrant aminopropyl carbazole that exhibits proneurogenic and neuroprotective activity by preventing apoptosis of newly postmitotic neurons in the subgranular zone of the hippocampal dentate gyrus. At doses of 5 mg/kg and above, it has been shown to promote the survival of neurons in various rodent models of neurodegeneration or nerve injury. While the precise mechanism of action through which these effects are exerted remains uncertain, P7C3 recently has been shown to bind nicotinamide phosphoribosyltransferase, the rate-limiting enzyme involved in the conversion of nicotinamide into NAD.

VerwendenP7C3 is an aminopropyl carbazole agent with proneurogenic and neuroprotective properties in newborn neural precursor cells of the dentate gyrus. Its analogs may be used in neurodegenerative disease research to study the process of neurogenesis in brain regions such as the subgranular zone of the hippocampal dentate gyrus. P7C3 and its analogs may be used to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as potential drug for the treatment of condition such as Alzheimer′s disease, Parkinson′s disease, amyotrophic lateral sclerosis and traumatic brain injury.