(±)-(3-Carboxy-2-hydroxypropyl)trimethylammoniumhydroxid

Cardiogen · Carrier · Cardiogen peptide · Carnum · Miocor · C00487 · Novaine · Excitine

Identifikatoren & physikalische Daten

CAS No.	406-76-8
Summenformel	C7H15NO3
Durchschnittliche Molmasse	161,2 g/mol
Monoisotopische Masse	161,10519334 g/mol
SMILES	C[N+](C)(C)CC(O)CC(=O)[O-]
InChIKey	PHIQHXFUZVPYII-UHFFFAOYSA-N
PubChem CID	288
ChEMBL	CHEMBL172513
ChEBI	CHEBI:17126
EC No.	206-976-6
DTXSID	DTXSID3022744
Lokaler Name	(±)-(3-Carboxy-2-hydroxypropyl)trimethylammoniumhydroxid

Chemische & physikalische Eigenschaften

XLogP	-0,2
Polarare Oberfläche (TPSA)	60,4
H-Brücken-Donoren	1
H-Brücken-Akzeptoren	3
Frei drehbare Bindungen	3
Schwere Atome	11
Formalladung	0
Komplexität	134
Kosmetika	Cosmetic ingredients (Carnitine) -> CIR (Cosmetic Ingredient Review)CleansingFoam boosting
Dietary Ingredients	Carnitine
Collision Cross Section	131.39 Å² [M]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards]
Schmelzpunkt	197-198 °C (decomp)
Lagerbedingungen	Store at -20°C
Löslichkeit	Soluble in DMSO
InChI	InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3
InChIKey	PHIQHXFUZVPYII-UHFFFAOYSA-N
SMILES	C(C(O)CC([O-])=O)[N+](C)(C)C

Sicherheit & Vorschriften

Regulatorische Informationen	Carnitine: Does not have an individual approval but may be used under an appropriate group standard
Expositionspfade	Intravenous, Oral. Absolute bioavailability is 15% (tablets or solution). Time to maximum plasma concentration was found to be 3.3 hours.
Toxizitätsübersicht	The CIR Expert Panel concluded the following ingredients are safe in the present practices of use and concentration described in the safety assessment when formulated to be non-irritating...Carnitine...Safe for use in cosmetics, with qualificationsLevocarnitine can be synthesised within the body from the amino acids lysine or methionine. Vitamin C (ascorbic acid) is essential to the synthesis of carnitine. Levocarnitine is a carrier molecule in the transport of long chain fatty acids across the inner mitochondrial membrane. It also exports acyl groups from subcellular organelles and from cells to urine before they accumulate to toxic concentrations. Only the L isomer of carnitine (sometimes called vitamin BT) affects lipid metabolism. Levocarnitine is handled by several proteins in different pathways including carnitine transporters, carnitine translocases, carnitine acetyltransferases and carnitine palmitoyltransferases.
Signs and Symptoms	Adverse effects include hypertension, fever, tachycardia and seizures.
Carcinogen Classification	No indication of carcinogenicity to humans (not listed by IARC).
Toxicity Data	LD<sub>50</sub> > 8g/kg (mouse, oral).
Alarmwort	Warnung
Gefahrenhinweise	Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H302

Anwendungen & Verwendung

Verwenden

DL-Carnitine is a Chloride salt free form of D,L-Carnitine Chloride (C184100). Carnitine is a vitamin, essential cofactor of fatty acid metabolism. It is required for the transport of fatty acids through the inner mitochondrial membrane. Synthesized primarily in the liver and kidney; highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado.