2-[(6-phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino]ethanol
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Grundinformationen
- CAS
425399-05-9- Standard-SMILES
OCCNC1CCCc2c1[nH]c1ccc(-c3ccccc3)cc21- InChIKey
RXIUMAOXORBRCY-UHFFFAOYSA-N- Summenformel
- C20H22N2O
- Durchschnittliche Molmasse
- 306,409 g/mol
- Monoisotopische Masse
- 306,17321332
Namen und Bezeichner
- Bevorzugter Name
- 2-[(6-phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino]ethanol
- IUPAC
- 2-[(6-Phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino]ethan-1-ol
- Englischer Name
- CASIN
- Summenformel
- C20H22N2O
- Molmasse
- 306.4
Namen und Synonyme
CASINCasin, >98%CASIN >=98% (HPLC)CASIN, 10 mM in DMSOPirl1-related Compound 22-(6-phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-ylamino)ethanol2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol2-((6-Phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino)ethan-1-olEthanol, 2-[(2,3,4,9-tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]-Ras,multiple myeloma,drug resistance,inhibit,Apoptosis,Inhibitor,CASIN,bortezomib
Datenbank-Bezeichner
- CAS
425399-05-9、6044-86-6- PubChem CID
- 2882155
- DTXSID
DTXSID80387144- ChEMBL
CHEMBL4303199- EC Number
- 839-822-7
Eigenschaften
Physikochemische Eigenschaften
- Siedepunkt
- 577.8 · 577.8±50.0 °C(Predicted)
- Dichte
- 1.23 · 1.23±0.1 g/cm3(Predicted)
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- 30.6 mg/mL · ≥30.6 mg/mL in DMSO; insoluble in H2O; ≥19.5 mg/mL in EtOH
- Aggregatzustand
- powder
- pka
- 14.76 · 14.76±0.10(Predicted)
- Farbe
- white to very dark brown
- InChI
- 1S/C20H22N2O/c23-12-11-21-19-8-4-7-16-17-13-15(14-5-2-1-3-6-14)9-10-18(17)22-20(16)19/h1-3,5-6,9-10,13,19,21-23H,4,7-8,11-12H2
- InChIKey
- RXIUMAOXORBRCY-UHFFFAOYSA-N
- SMILES
- OCCNC1CCCC2=C1NC3=C2C=C(C4=CC=CC=C4)C=C3
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- WGK 3
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Anwendungen
BeschreibungThe Rho family of GTPases regulates diverse signal transduction pathways. One member, the cell division control protein 42 homolog (Cdc42), is involved in filopodia function, cell polarity, cell cycling, and other processes. CASIN is an indole-based small molecule that inhibits activation of the Cdc42 GTPase (IC50 = 2 μM for inhibiting actin assembly in PIP2-stimulated actin polymerization assays). This compound has been used to explore the role of Cdc42 in the division, survival, and differentiation of hematopoietic stem cells.
VerwendenCASIN has been used as a cell division control protein 42 homolog (Cdc42) inhibitor:to study its effects on the stimulation of extracellular vesicles (EVs) in intestinal epithelial cellsto study its effects on mice jejunumto study its effects on microbial adhesion-triggered endocytosis (MATE) vesicle morphology in segmented filamentous bacteria (SFB)-colonized mice
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