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Cyclopentylamin
Cyclopentanamine · Cyclopentylamine,Aminocyclopentane · cb1689 · Ring aMylaMine · CYCLOPENTYLAMINE · AMINOCYCLOPENTANE · AKOS BBS-00003621 · cychlopentylamine
Identifikatoren & physikalische Daten
| CAS No. | 1003-03-8 |
|---|---|
| Summenformel | C5H11N |
| Durchschnittliche Molmasse | 85,15 g/mol |
| Monoisotopische Masse | 85,08914936 g/mol |
| SMILES | NC1CCCC1 |
| InChIKey | NISGSNTVMOOSJQ-UHFFFAOYSA-N |
| PubChem CID | 2906 |
| ChEMBL | CHEMBL1171859 |
| EC No. | 213-697-3 |
| DTXSID | DTXSID4061387 |
| Lokaler Name | Cyclopentylamin |
Chemische & physikalische Eigenschaften
| XLogP | 0,6 |
|---|---|
| Polarare Oberfläche (TPSA) | 26 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 1 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 6 |
| Formalladung | 0 |
| Komplexität | 37 |
| Schmelzpunkt | -85°C |
| Siedepunkt | 106-108 °C(lit.) |
| Dichte | 0.863 g/mL at 25 °C(lit.) |
| Dampfdruck | 26.72hPa at 20℃ |
| Brechungsindex | n20/D 1.450(lit.) |
| Flammpunkt | 63 °F |
| Lagerbedingungen | Flammables area |
| Aggregatzustand | Liquid |
| pKa (Säurekonstante) | pK1:10.65(+1) (25°C) |
| Farbe | Clear |
| Explosionsgrenze | 1.3-9.40%(V) |
| Löslichkeit | MISCIBLE |
| Spezifische Wärmekapazität | Cp(liquid): 2.13 J/(g·K), at 25℃ |
| BRN | 635706 |
| InChI | 1S/C5H11N/c6-5-3-1-2-4-5/h5H,1-4,6H2 |
| InChIKey | NISGSNTVMOOSJQ-UHFFFAOYSA-N |
| SMILES | NC1CCCC1 |
| LogP (Verteilungskoeffizient) | 0.83 at 20℃ |
| CAS Datenbank | 1003-03-8(CAS DataBase Reference) |
| NIST chemische Informationen | Cyclopentanamine(1003-03-8) |
| EPA chemische Informationen | Cyclopentanamine (1003-03-8) |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 0.6% (1 of 154) of reports.DangerH225 (99.4%): Highly Flammable liquid and vapor [Danger Flammable liquids]H300 (97.4%): Fatal if swallowed [Danger Acute toxicity, oral]H314 (74.7%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]H315 (25.3%): Causes skin irritation [Warning Skin corrosion/irritation]H317 (31.2%): May cause an allergic skin reaction [Warning Sensitization, Skin]H318 (94.2%): Causes serious eye damage [Danger Serious eye damage/eye irritation]H331 (69.5%): Toxic if inhaled [Danger Acute toxicity, inhalation]H332 (26.6%): Harmful if inhaled [Warning Acute toxicity, inhalation]H412 (68.8%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P332+P317, P333+P317, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 154 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Reported as not meeting GHS hazard criteria per 1 of 154 reports by companies.There are 9 notifications provided by 153 of 154 reports by companies with hazard statement code(s).Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| Regulatorische Informationen | Status: Active Update: 28-08-2013 https://echa.europa.eu/registration-dossier/-/registered-dossier/7046Status: Active Update: 29-01-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/10145Cyclopentylamine: Does not have an individual approval but may be used under an appropriate group standard |
| Hazard Classes and Categories | Flam. Liq. 2 (99.4%)Acute Tox. 2 (97.4%)Skin Corr. 1B (74.7%)Skin Irrit. 2 (25.3%)Skin Sens. 1 (31.2%)Eye Dam. 1 (94.2%)Acute Tox. 3 (69.5%)Acute Tox. 4 (26.6%)Aquatic Chronic 3 (68.8%) |
| F | 8-10-23 |
| Wassergefährdungsklasse (WGK) | 3 |
| TSCA-Inventar-Status | TSCA listed |
| UN-Transportnummer | UN 2733 3/PG 2 |
| Zollcode | 29213099 |
| RTECS-Nr. | GY8452000 |
| R-Sätze (R) | 11-37/38-43-34-25-20 |
| Gefahrensymbole | F,Xi,T |
| Sicherheitshinweise (S) | 16-45-36/37/39-25-26 |
| Gefahrenklasse | 3Acute Tox. 2 OralAcute Tox. 3 InhalationAquatic Chronic 3Eye Dam. 1Flam. Liq. 2Skin Corr. 1BSkin Sens. 1 |
| Verpackungsgruppe | II |
| Lagerklasse | 3 - Flammable liquids |
Anwendungen & Verwendung
Verwenden
Cyclopentylamine acts as an important raw material and intermediate used in organic synthesis and pharmaceuticals. Further, it serves as chemokine receptor 2 antagonists. It acts as a ligand in coordination chemistry and forms cis-dichlorobis(cyclopentylamine)platinum(II) complex.
Herstellung & Synthese
synthetische
Cyclopentylamine is produced from cyclopentanone and ammonia over nickel catalysts at 20 MPa and 150 – 200℃ in the presence of circulating hydrogen over a fixedbed catalyst.