Grundinformationen
- CAS
77-39-4- Standard-SMILES
OC(CCN1CCCCC1)(c1ccccc1)C1CCCC1- InChIKey
SWRUZBWLEWHWRI-UHFFFAOYSA-N- Summenformel
- C19H29NO
- Durchschnittliche Molmasse
- 287,4 g/mol
- Monoisotopische Masse
- 287,22491455
Überblick
Cycrimine is a member of the class of piperidines that is 3-(piperidin-1-yl)propan-1-ol in which one of the hydrogen atoms at the 1-position is substituted by cyclopentyl, and the other is substituted by phenyl. A central anticholinergic, it is used as its hydrochloride salt in the management and treatment of Parkinson's disease. It has a role as an antiparkinson drug, a muscarinic antagonist and an antidyskinesia agent. It is a member of piperidines, a tertiary alcohol and a tertiary amino compound.
Namen und Bezeichner
- Bevorzugter Name
- Cycrimine
- IUPAC
- 1-cyclopentyl-1-phenyl-3-piperidin-1-ylpropan-1-ol
- Lokaler Name
- Cycrimin
- Englischer Name
- cycrimine
- Summenformel
- C19H29NO
- Molmasse
- 287.444
Namen und Synonyme
cycrimine77-39-4CicriminaCycriminum(+-)-cycrimine1-cyclopentyl-1-phenyl-3-(piperidin-1-yl)propan-1-olalpha-Cyclopentyl-alpha-phenyl-1-Piperidinepropanol543567RFQQCHEBI:59692DTXSID508617691-Piperidinepropanol, alpha-cyclopentyl-alpha-phenyl-RefChem:130055
Weitere Namen anzeigen
cycrimine USP/EP/BP1-Piperidinepropanol, α-cyclopentyl-α-phenyl-α-Cyclopentyl-α-phenyl-1-piperidine-1-propanol1-Phenyl-1-cyclopentyl-3-piperidino-1-propanol1-cyclopentyl-1-phenyl-3-piperidino-propan-1-ol1-cyclopentyl-1-phenyl-3-piperidin-1-yl-propan-1-ol
DTXCID50810651alpha-cyclopentyl-alpha-phenyl-1-piperidinepropanol.HCl201-024-61-cyclopentyl-1-phenyl-3-piperidin-1-ylpropan-1-ol1-Piperidinepropanol, a-cyclopentyl-a-phenyl-1-Piperidinepropanol, .alpha.-cyclopentyl-.alpha.-phenyl-.alpha.-Cyclopentyl-.alpha.-phenyl-1-piperidinepropanolCycriminum [INN-Latin]
Datenbank-Bezeichner
- CAS
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 3,9
- Polarare Oberfläche (TPSA)
- 23,5 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 2
- Frei drehbare Bindungen
- 5
- Schwere Atome
- 21
- Formalladung
- 0
- Komplexität
- 301
Experimentelle und physikochemische Eigenschaften
LogP4
Solubility9.09e-03 g/L
Melting Point112-113
Physical DescriptionSolid
Physikochemische Eigenschaften
- Schmelzpunkt
- 90 · 90-92°C
- Siedepunkt
- 125 · 125-135 °C(Press: 0.02 Torr)
- Dichte
- 1.057 · 1.057±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C · -20°C Freezer, Under inert atmosphere
- Löslichkeit
- Chloroform (Slightly), Ethyl Acetate, Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 14.4 · 14.40±0.29(Predicted)
- Farbe
- Off-White to Pale Yellow
- Stabilität
- Stable under recommended storage conditions., Stable Under Recommended Storage C
Chemie und Industrie
Pharmakologische Informationen
Protein Binding14-21%
Pharmacodynamics
Cycrimine is a central anticholenergic used in the treatment of the symptoms of Parkinson's disease. It is a drug used to reduce levels of acetylcholine. Acetylcholine is usually in balance with dopamine neurotransmitters, however lower levels of dopamine are present in the brain of patients suffering from Parkinson's disease. By lowering levels of acetylcholine, it is thought that this balance may be restored.
Mechanism of ActionCycrimine binds the muscarinic acetylcholine receptor M1, effectively inhibiting acetylcholine. This decrease in acetylcholine restores the normal dopamine-acetylcholine balance and relieves the symptoms of Parkinson's disease.
Cellular LocationsMembrane
Anwendungen
VerwendenCycrimine is a cholinolytic anti-Parkinson drug which can cause neuromuscular blockades in isolated rat diaphragms.
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