| GHS-Einstufung | DangerH301: Toxic if swallowed [Danger Acute toxicity, oral]P260, P261, P262, P264, P270, P271, P273, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P330, P361+P364, P363, P391, P403+P233, P405, and P501 (click each P-code to see the statement)H301+H311+H331 (17.1%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oralacute toxicity, dermalacute toxicity, inhalation]P260, P261, P262, P264, P264+P265, P270, P271, P273, P280, P284, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P320, P321, P330, P361+P364, P363, P391, P403+P233, P405, and P501 (click each P-code to see the statement) |
|---|
| Regulatorische Informationen | Chemical: Acetic acid, chloro-Hazard Traits - DermatotoxicityNeurotoxicityOcular ToxicityRespiratory ToxicityAcetic acid, 2-chloro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Acetic acid, 2-chloro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 08-06-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/15187Chloroacetic acid: HSNO Approval: HSR003030 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
|---|
| Weitere Sicherheitsinformationen | IMAP assessments - Acetic acid, chloro-: Human health tier II assessment |
|---|
| DOT-Kennzeichnung | Poison Corrosive |
|---|
| Brandgefahren | When heated to decomposition, it emits highly toxic fumes of phosgene and chlorides. Water may cause frothing if it gets below surface of the liquid and turns to steam. Flammable/poisonous gases may accumulate in tanks and hopper cars. Some of these materials may ignite combustibles, e.g., wood, paper, oil. It is corrosive to metals. Avoid heating. (EPA, 1998)Special Hazards of Combustion Products: Toxic gases, such as hydrogen chloride, phosgene and carbon monoxide, may be generated. (USCG, 1999)· Combustible material: may burn but does not ignite readily.Combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
|---|
| Brandpotenzial | Combustible liquid when exposed to heat or flame. |
|---|
| Gesundheitsgefahren | This material is very toxic. The probable lethal oral dose is 50-500 mg/kg of body weight, between one teaspoon and one ounce, for a 150 lb. person. Chloroacetic acid is irritating to the skin, cornea, and respiratory tract and causes burns. It may severely damage skin and mucous membranes. Ingestion may interfere with essential enzyme systems and cause perforation and peritonitis. Burns to skin result in marked fluid and electrolyte loss. Death may follow if more than 3% of the skin is exposed to this material. Other health hazards include central nervous system depression, and respiratory system depression. Persons with lung diseases are at greater risk. (EPA, 1998)Inhalation causes mucous membrane irritation. Contact with liquid causes severe irritation and burns of the eyes and irritation and burns of skin. Ingestion causes burns of mouth and stomach. (USCG, 1999)· TOXIC and/or CORROSIVEinhalation, ingestion or skin contact with material may cause severe injury or death. |
|---|
| Gefahrenübersicht | Exposure to chloroacetic acid is most likely to occur in the workplace. Acute (short-term) inhalation or dermal exposure may irritate or cause severe damage to the skin, eyes, respiratory tract, and mucous membranes and cause depression of the central nervous system in humans. No information is available on the chronic (long-term) effects of chloroacetic acid in humans. Damage to the respiratory tract has been observed in rodents chronically exposed to chloroacetic acid by inhalation, orally, and via gavage (experimentally placing the chemical in the stomach). EPA has not classified chloroacetic acid for potential carcinogenicity.Corrosive to skin[Quick CPC] Inhalation of aerosol can cause lung edemaMay be toxic to the heart, kidneys, and CNS[ICSC] A severe skin, eye, and respiratory tract irritantLiquid can burn skin and eyes[CAMEO] Several accidents have been describedMolten MCA causes severe burnsit is absorbed through the skinSigns of poisoning include metabolic acidosis, cardiac arrhythmias, disorientation, coma, rhabdomyolysis, renal failure, and cerebral edema[AIHA] |
|---|
| DOT-Nummer und Handbuch | 1751 1531750 1533250 153 |
|---|
| FDA-Anforderungen | Monochloracetic acid is an indirect food additive for use only as a component of adhesives.(a) Monochloroacetic acid is the chemical chloroacetic acid ... It is a synthetic chemical not found in natural products, and has been proposed as a preservative in alcoholic and nonalcoholic beverages. Monochloroacetic acid is permitted in food package adhesives with an accepted migration level up to 10 parts per billion (ppb) under section 175.105 of this chapter. The official methods do not detect monochloroacetic acid at the 10 ppb level. (b) Food containing any added or detectable level of monochloroacetic acid is deemed to be adulterated in violation of the act based upon trade correspondence dated December 29, 1941 (TC-377). |
|---|
| Reaktive Gruppe | Acids, Carboxylic |
|---|
| EG-Einstufung | Symbol: T, C, NR: 23/24/25-34-50S: (1/2)-26-36/37/39-45-61-63 |
|---|
| UN-Einstufung | UN Hazard Class: 6.1UN Subsidiary Risks: 8UN Pack Group: II |
|---|
| Brandbekämpfung | This material is extremely hazardous to health, but fire fighters may enter areas with extreme care. Full protective clothing including a self-contained breathing apparatus, coat, pants, gloves, boots and bands around legs, arms and waist should be provided. No skin surface should be exposed. Cool fire-exposed containers with water. Move container from fire area if you can do so without risk. Spray cooling water on containers that are exposed to flames until well after fire is out.Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. |
|---|
| Erste-Hilfe-Maßnahmen | Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention.Wear protective gloves when administering first aid. First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer immediately for medical attention.Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention. |
|---|
| Freisetungsmaßnahmen | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. |
|---|
| Erste Hilfe | Warning: Effects may be delayed. Caution is advised. Chloroacetic acid is extremely corrosive.Get medical attention for all exposures to this compound.General First Aid: |
|---|
| Sichere Lagerung | Separated from incompatible materials and food and feedstuffs. See Chemical Dangers. Dry. Store only in original container. Well closed. Ventilation along the floor. Store in an area without drain or sewer access. |
|---|
| Firefighting Hazards | Gives off irritating or toxic fumes (or gases) in a fire. |
|---|
| Expositionsschutz und Persönliche Schutzausrüstung | · Wear positive pressure self-contained breathing apparatus (SCBA).0.5 [ppm] |
|---|
| Brandbekämpfungsverfahren | Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.This material is extremely hazardous to health, but fire fighters may enter areas with extreme care. Full protective clothing incuding a self-contained breathing apparatus, coat, pants, gloves, boots and bands around legs, arms and waist should be provided. No skin surface should be exposed. Move container from fire area if you can do so without risk. Spray cooling water on containers that are exposed to flame until well after fire is out. This chemical may burn but does not readily ignite. Use dry chemical, carbon dioxide, water spray, or foam extinguishers. Poisonous gases are produced in fire, including chlorine and phosgene. /SRP: are produced during thermal breakdown/. If materials or contaminated runoff enter waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors, or shows any signs of deforming), withdraw immediately to a secure position. If employees are expected to fight fires, they must be trained and equipped.If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. /Chloroacetic acid, moltenChloroacetic acid, solid/For more Fire Fighting Procedures (Complete) data for Chloroacetic acid (9 total), please visit the HSDB record page. |
|---|
| Lagerbedingungen | Keep container tightly closed in a dry and well-ventilated place.Prior to working with chloroacetic acid you should be trained on its proper handling and storage. Store in tightly closed containers in a cool, well-ventilated area away from metal, combustibles, strong oxidizers, strong bases, and reducing agents. Where possible, automatically pump liquid from drums or other storage containers to process containers. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use only non-sparking tools and equipment, especially when opening and closing containers of this chemical. Sources of ignition such as smoking and open flames are prohibited where this chemical is used, handled, or stored in a manner that could create a potential fire or explosion hazard.Store in a cool, dry, well-ventilated location. Separate from alkalies, alcohols, oxidizing materials, reducing agents, and metals.... MCA is stored and transported as flakes or as an 80% aqueous solution in transport tanks at 35 °C (it solidifies at 19 °C). It may also be dissolved in ethanol or methanol. ... |
|---|
| Reinigungsverfahren | ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.Stay upwindkeep out of low areas. Evacuate persons not wearing protective equipment from area of spill or leak until cleanup is complete. Neutralize spilled materials with crushed limestone, soad ash, or lime. Waste water containing chloroacetic acid can be treated with ammonia, ammonium salts, or amines followed by separation of suspended solids. Collect powdered material in the most convenient and safe manner and deposit in sealed containers. Dike large spills far ahead of spill for later disposal. Ventilate area of spill or leak after clean-up is complete. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your local or federal environmental protection agency for specific recommendations. If employees are required to clean-up spills, they must be properly trained and equipped.Approach release from upwind. Absorb in noncombustible material for proper disposal.Environmental considerations: Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ /Chloroacetic acid, molten/For more Cleanup Methods (Complete) data for Chloroacetic acid (7 total), please visit the HSDB record page. |
|---|
| Freisetung ohne Brand | Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: |
|---|
| Entsorgungsverfahren | SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in air, soil or watereffects on animal, aquatic and plant lifeand conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Contaminated packaging: Dispose of as unused product.Incineration, preferably after mixing with another combustible fuelcare must be exercised to assure complete combustion to prevent the formation of phosgenean acid scrubber is necessary to remove the halo acids produced. |
|---|
| Körperbelastung | Disinfection of water in swimming pools and spas may result in higher levels of haloacetic acids than in disinfected tap water. Dermal and inhalation exposure are not major routes of exposure as these compounds are not volatile nor readily absorbed through the skin. Accidental ingestion of treated water accounts for the major, approximately 94%, route of exposure(1). /Haloacetic acids/ |
|---|
| Wechselwirkungen | The effects of glucose infusion on monochloroacetate (MCA) exposure were examined in male rats with a view toward effective clinical treatment for MCA intoxication. Rats were injected with 80 mg/kg sodium monochloroacetate (SMCA) (single lethal dose) and then infused with saline (control group) or 5% or 10% glucose solution at 2 mL/hour for ten hours. No animal in the control group survived the total 14-day follow-up period. The survival rate in 5% glucose group was 57% at ten hoursit decreased to 14% at 14 days. The survival rate in 10% glucose group was 79% at ten hours, and all rats that survived the first ten hours also survived the 14 days. Kaplan-Meier analysis showed the survival rate in 10% glucose group to be improved upon in both the 5% glucose group and the control group. Blood glucose and lactate levels were measured every hour during infusion. Blood glucose levels decreased in the control group but remained in the glucose-infused groups. Although the blood lactate level increased in each group, there was an excellent inverse linear relation between blood glucose levels and blood lactate levels. Thus, continuous parenteral infusion of glucose solution at an early stage after exposure may be an effective clinical therapy for the prevention of hypoglycemia and metabolic lactic acidosis caused by MCA.... Pretreatment of /male mice of ddY strain/ with either diethyldithiocarbamate or carbon disulfide ... did not prevent the hypothermia induced by monochloroacetic acid. ...... A 23-year old chemical technician ... spilt MCAA over the dorsum of his right hand and forearm. The solution contained 1.5 M MCAA in ethanol 94%. The arm was rinsed with water for 10 minutesdespite this, erythema and small blisters appeared in the first hour. The lesions healed in 10 days with small scars. After 14 days, itchy vesicles appeared at the site of the scars. On day 28 the patient was patch tested with the international standard series and the MCAA solution 1% in methanol 70%. A strong 4+ reaction was observed to the MCAA solution. Two control persons were negative. According to the authors the ethylester of MCAA (EMCA) was suspected as the causative agent (MCAA + ethanol may react to EMCA and water). On day 49, patch testing was performed with 1% EMCA (purity 99.9%) in acetone and ethanol and 1% MCAA in aq. Strong 4+ reactions were observed to the patches with EMCA, MCAA was negative.In an experiment to investigate whether ethanol can be used as antidote of MCAA toxicity ... high exposure doses were used so that rabbit skin contamination with MCAA was normally always fatal to the animals. ... Ethanol was unable to prevent death, even with maximum ethanolization (3 g/L in blood). The mean mortality delay was higher in rabbits infused with ethanol after MCAA exposure than in rabbits not infused with ethanol. It seems that blood glucose, potassium, and HC03- were slightly less modified in ethanolized animals than in non-ethanolized animals.For more Interactions (Complete) data for Chloroacetic acid (6 total), please visit the HSDB record page. |
|---|
| Ökotoxizitätswerte | Tubifex tubifex (worm) perturbation concn, 150 mg/LParamecium caudatum (protozoan) toxic /concentration/, 150 mg/LGammarus pulex (water shrimp) perturbation concn, 30 mg/LChironomus plumosus (midge) perturbation concn, 140 mg/LFor more Ecotoxicity Values (Complete) data for Chloroacetic acid (19 total), please visit the HSDB record page. |
|---|
| Umweltverhalten | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 2(SRC), determined from a log Kow of 0.22(2) and a regression-derived equation(3), indicates that chloroacetic acid is expected to have very high mobility in soil(SRC). The pKa of chloroacetic acid is 2.87(4), indicating that this compound will exist almost entirely in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Volatilization from moist soil is not expected because the compound exists as an anion and anions do not volatilize. Chloroacetic acid is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 6.5X10-2 mm Hg at 25 °C(6). Utilizing the Japanese MITI test, 65% of the Theoretical BOD was reached in 3 weeks with acclimation(7) indicating that biodegradation may be an important environmental fate process in soil under specific conditions(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 2(SRC), determined from a log Kow of 0.22(2) and a regression-derived equation(3), indicates that chloroacetic acid is not expected to adsorb to suspended solids and sediment(SRC). A pKa of 2.87(4) indicates chloroacetic acid will exist almost entirely in the anion form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process(SRC). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). No biodegradation was reported for chloroacetic acid following 3 days incubation in both river water and seawater(6), indicating that biodegradation may not be an important environmental fate process in water(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), chloroacetic acid, which has a vapor pressure of 6.5X10-2 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase chloroacetic acid is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 20 days(SRC), calculated from its rate constant of 7.9X10-13 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Chloroacetic acid absorbs UV light at wavelengths 218 nm(4) and, therefore, is not expected to be susceptible to direct photolysis since sunlight consists of wavelengths above 290 nm(SRC). |
|---|
| Lebensmitteluntersuchungswerte | Exposure to haloacetic acids may also occurr when drinking beverages made with chlorinated water such as tea, coffee, fruit drinks and soft drinks or when eating foods that has been rinsed with or cooked in chlorinated water. Median concentrations range from <1 ug/kg in milk to >10 ug/kg in soft drinks(1). /Haloacetic acids/ |
|---|
| Unerwünschte Wirkungen | Neurotoxin - Other CNS neurotoxin |
|---|
| Expositionspfade | The substance can be absorbed into the body by inhalation, through the skin and by ingestion. |
|---|
| Milk Concentrations | ... Median concentration ... <1 ug/kg in milk ...(1). /Haloacetic acids/ |
|---|
| Toxizitätsübersicht | IDENTIFICATION AND USE: Chloroacetic acid (MCA) is a solid. Most of the chloroacetic acid produced is used to manufacture several hundred thousand tons annually of carboxymethyl cellulose. Another major application is the production of herbicides based on arylhydroxyacetic acids. HUMAN STUDIES: The anticipated acute and chronic human health hazards posed by MCA are effects on the cardiac system, the central nervous system, and kidneys. In addition, MCA is highly corrosive and irritating to the eyes, skin and respiratory tract. Acute dermal exposure of workers to MCA may result in death even after rapid and extensive washing of the skin area. The effects may be delayed. The biochemical mechanism of action resulting in death is not understood. Contributing factors apparently believed to be involved are: (i) the inhibition of the tricarboxylic acid cycle decreasing cellular energy supply and increasing acidosis with glycolic acid and oxalate production, and(ii) effects on cellular components where sulfhydryl groups are critical for normal biological activity. Both of these effects may contribute to CNS, cardiovascular, renal and hepatic effects. In addition, the metabolites glycolic acid and oxalate may contribute to CNS and renal toxicity. A case of joint deformity reported after the use of a preparation containing MCA for topical wart treatment. MCA did not induce DNA strand breaks in human CCRF-CEM cells. ANIMAL STUDIES: Fatalities among rabbits are expected when only 3% of the skin is exposed. Thorough washing after 1 minute contact did not decrease mortalities. In rats after subcutaneous administration of MCA (108, 135 or 163 mg/kg) hypoglycemia and lung injury appear to cause death in response to MCA exposure. MCA caused front paw rigidity in 10% of mice surviving a single oral toxic dose (320-380 mg/kg). Male mice orally administered 300 mg/kg bw MCA showed tremors, respiratory depression, and occasionally tonic and clonic convulsions. Some survivors had a Straub tail, severe tremors, and front limb paralysis after 24 hours (after exposure). Pregnant rats were dosed MCA by oral intubation on gestation days 6 to 15 with 0, 17, 35, 70, or 140 mg/kg bw/day. The percentage of soft tissue malformations was increased, however not dose-related. No skeletal malformations were found. In the highest dose-group a statistically significant increase of malformations of the cardiovascular system, comprising predominantly levocardia, was found. MCA was not mutagenic in Salmonella typhimurium strains (TA98, TA100, TA102, TA104, TA1535, TA1537, and TA1538) and Escherichia coli strains (WP2uvrA and WP2uvrA/pKM101) with or without metabolic activation. ECOTOXICITY STUDIES: A large number of passerine birds, mainly greenfinches, were found dead or dying in a hedgerow close to a field of onions recently sprayed with sodium salt of MCA. Chemical analysis confirmed the exposure of the birds to the chemical. MCA had high regeneration toxicity with teratogenicity in Hydra digestive region. |
|---|
| Ökotoxizitätsauszüge | /BIRDS and MAMMALS/ A large number of passerine birds, mainly greenfinches, were found dead or dying in a hedgerow close to a field of onions recently sprayed with sodium monochloroacetate (SMCA). ... Chemical analysis confirmed the exposure of the birds to SMCA. It is calculated that 50 uL of spray contained the lethal dose of SMCA for a greenfinch. /Sodium monochloroacetate//BIRDS and MAMMALS/ ... The geese suffered no ill effects when simply moving around an SMCA-treated pasture without feeding, but 4/6 died within 24 hours of ingesting treated plants in a second pasture sprayed with 20 kg/hectare and 3/6 died after feeding on plants dosed at 40 kg/hectare. /Sodium salt of monochloroacetic acid (SMCA)//AQUATIC SPECIES/ Using seawater for toilet flushing may introduce high levels of bromide and iodide into a city's sewage treatment works, and result in the formation of brominated and iodinated disinfection byproducts (DBPs) during chlorination to disinfect sewage effluents. In a previous study, the authors' group has detected the presence of many brominated DBPs and identified five new aromatic brominated DBPs in chlorinated saline sewage effluents. The presence of brominated DBPs in chlorinated saline effluents may pose adverse implications for marine ecology. In this study, besides the detection and identification of another seven new aromatic halogenated DBPs in a chlorinated saline sewage effluent, their developmental toxicity was evaluated using the marine polychaete Platynereis dumerilii. For comparison, the developmental toxicity of some commonly known halogenated DBPs was also examined. The rank order of the developmental toxicity of 20 halogenated DBPs was 2,5-dibromohydroquinone > 2,6-diiodo-4-nitrophenol >/= 2,4,6-triiodophenol > 4-bromo-2-chlorophenol >/= 4-bromophenol > 2,4-dibromophenol >/= 2,6-dibromo-4-nitrophenol > 2-bromo-4-chlorophenol > 2,6-dichloro-4-nitrophenol > 2,4-dichlorophenol > 2,4,6-tribromophenol > 3,5-dibromo-4-hydroxybenzaldehyde > bromoform >/= 2,4,6-trichlorophenol > 2,6-dibromophenol > 2,6-dichlorophenol > iodoacetic acid >/= tribromoacetic acid > bromoacetic acid > chloroacetic acid. On the basis of developmental toxicity data, a quantitative structure-activity relationship (QSAR) was established. The QSAR involved two physical-chemical property descriptors (log P and pKa) and two electronic descriptors (the lowest unoccupied molecular orbital energy and the highest occupied molecular orbital energy) to indicate the transport, biouptake, and biointeraction of these DBPs. It can well predict the developmental toxicity of most of the DBPs tested./AQUATIC SPECIES/ The fate of monochloroacetic acid (MCA), a common phytotoxic aquatic contaminant, and its toxicity to the aquatic macrophytes Lemna gibba (L. gibba), Myriophyllum spicatum (M. spicatum), and Myriophyllum sibiricum (M. sibiricum) under semi-natural field conditions was studied. Replicate 12,000 L enclosures were treated with 0, 3, 10, 30 and 100 mg/L of MCA. Each microcosm was stocked with eight individual apical shoots of M. spicatum and M. sibiricum 1 day prior to initiation of exposure. Plants were sampled after 4, 7, 14 and 28 days of exposure and their response assessed using numerous somatic and biochemical endpoints. L. gibba was introduced into the microcosms the day of MCA treatment and monitored regularly for 21 days. The half-life of MCA in the water column ranged between 86 and 523 hr. The most sensitive plant species was M. spicatum, followed by M. sibiricum and L. gibba. All species demonstrated toxicity within a threefold range of each other. Endpoint sensitivity varied depending on the duration of exposure and the level of effect chosen. Most species endpoint EC(x) values were less than an order of magnitude different. Citrate levels in Myriophyllum spp. were not influenced by exposure to MCA. The toxicity of MCA to M. spicatum and M. sibiricum was very similar and thus highly predictive of toxicity observed for each other. The EC(10) was a more conservative estimate of toxicity than the statistically derived no observed effect concentration. Current concentrations of MCA are not likely to pose a risk to these aquatic plants in surface waters.For more Ecotoxicity Excerpts (Complete) data for Chloroacetic acid (12 total), please visit the HSDB record page. |
|---|
| Signs and Symptoms | Sore throat. Cough. Shortness of breath. Burning sensation behind the breastbone. Laboured breathing. Symptoms may be delayed. Further see Ingestion.MAY BE ABSORBED! Redness. Pain. Skin burns. Further see Ingestion.Redness. Pain. Severe burns.Burns in mouth and throat. Abdominal pain. Vomiting. Diarrhoea. Convulsions. Shock or collapse. Unconsciousness. |
|---|
| Ongoing Test Status | The following link will take the user to the National Toxicology Program (NTP) Test Status of Agents Search page, which tabulates the results and current status of tests such as "Short-Term Toxicity Studies", "Long-term Carcinogenicity Studies", "Developmental Studies", "Genetic Toxicology Studies", etc., performed with this chemical. Testing status for chloeoacetic acid is available.[Available from, as of February 1, 2019: https://ntpsearch.niehs.nih.gov/?e=True&ContentType=Testing+Status]EPA has released the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assays/[USEPAICSS Dashboard ApplicationAvailable from, as of February 4, 2019: http://actor.epa.gov/dashboard/] |
|---|
| Luftstandards | This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Chloroacetic acid is produced, as an intermediate or a final product, by process units covered under this subpart.Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Chloroacetic acid is included on this list. |
|---|
| CERCLA-Meldepflichtmengen | Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Chloroacetic acid is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 100 or 10,000 lbs. Extremely hazardous substances that are solids are subject to either of two threshold planning quantities ... The lower quantity applies only if the solid exists in powdered form and has a particle size less than 100 micronsor is handled in solution or in molten formor meets the criteria for a National Fire Protection Association (NFPA) rating of 2, 3 or 4 for reactivity. If the solid does not meet any of these criteria, it is subject to the upper ... threshold planning quantity ... .Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 100 lb or 45.4 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b). |
|---|
| Landesrichtlinien für Trinkwasser | (FL) FLORIDA 14 ug/L |
|---|
| Federal Drinking Water Standards | The maximum contaminant level for haloacetic acids (five) (HAA5) is 0.060 mg/L. /Haloacetic acids (five) (HAA5) mean the sum of the concentrations in milligrams per liter of the haloacetic acid compounds (monochloroacetic acid, dichloroacetic acid, trichloroacetic acid, monobromoacetic acid, and dibromoacetic acid), rounded to two significant figures after addition./Monochloroacetic acid is listed in the 2018 Edition of the Drinking Water Standards and Health Advisories Tables. |
|---|
| Bundesrichtlinien für Trinkwasser | Maximum contaminant level goal for disinfection byproducts: monochloroacetic acid = 0.07 mg/L. |
|---|
