Betamethason
Celestone
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Grundinformationen
- CAS
378-44-9- Standard-SMILES
CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO- InChIKey
UREBDLICKHMUKA-UHFFFAOYSA-N- Summenformel
- C22H29FO5
- Durchschnittliche Molmasse
- 392,5 g/mol
- Monoisotopische Masse
- 392,19990218
Überblick
9-fluoro-11,17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one is a 21-hydroxy steroid.
Namen und Bezeichner
- Bevorzugter Name
- Celestone
- IUPAC
- 9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
- Lokaler Name
- Betamethason
- Englischer Name
- Betamethasone
- Summenformel
- C22H29FO5
- Molmasse
- 392.47
Namen und Synonyme
CelestoneHormezonGF120918ABebate.beta.-Methasone.beta.-Methasone alcoholC22H29FO59-Fluoro-16.beta.-methylprednisolone9alpha-Fluoro-16 beta-methyl-prednisolonePrednisolone, 9-fluoro-16.beta.-methyl-9.alpha.-Fluoro-16.beta.-methylprednisolone9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Weitere Namen anzeigen
BetamethasonBetametasonebetamethasone standardC22H29O5FDermabet17,21-trihydrFLUBENISOLONEBetamethazoneDexamethasone EP Impurity B
Dexamethasone - USP CRSMLS000686794Corticosterone, 1-dehydro-9-fluoro-17-hydroxy-16.beta.-methyl-SCHEMBL2757815CHEBI:93851HMS3259J08HMS3267M14HMS5079A12
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- XLogP
- 1,9
- Polarare Oberfläche (TPSA)
- 94,8 Ų
- H-Brücken-Donoren
- 3
- H-Brücken-Akzeptoren
- 6
- Frei drehbare Bindungen
- 2
- Schwere Atome
- 28
- Formalladung
- 0
- Komplexität
- 805
Experimentelle und physikochemische Eigenschaften
DrugsPharmaceuticals
LogP1.99
Physikochemische Eigenschaften
- Schmelzpunkt
- 235 · 235-237°C
- Siedepunkt
- 568.2 · 568.2±50.0 °C(Predicted)
- Dichte
- 1.1283 · 1.1283 (estimate)
- Brechungsindex
- 118 ° · 118 ° (C=1, Dioxane)
- storage temp.
- 0 · 0-6°C
- Löslichkeit
- Practically insoluble in water, sparingly soluble in anhydrous ethanol, very slightly soluble in methylene chloride.
- pka
- 12.13 · 12.13±0.70(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Biologische Quelle
- synthetic (organic)
- Wasserlöslichkeit
- 58 mg/L · 58mg/L(25 ºC)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 2
- hs_code
- 29379000
- RTECS-Nr.
- TU4000000
- risk_code
- 40-48/20/21-61
- Toxizität
- LD50 oral in mouse: > 4500mg/kg
- hazard_code
- Xi,Xn,T
- safety_code
- 22-36-45-53
- Speicherklasse
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- Giftige Stoffe Daten
- 378-44-9(Hazardous Substances Data)
- Hazard Classifications
- Repr. 1BSTOT RE 2
Chemie und Industrie
Anwendungen
BeschreibungShortly after the introduction of dexamethasone, betamethasone, which differs from dexamethasone only in configuration of the 16-methyl group, was made available for the treatment of rheumatic diseases and dermatologic disorders. This analogue, which contains a 16β-methyl group, has received sufficient clinical trial examination to indicate that it is as effective as dexamethasone or, perhaps, even slightly more active. Although this drug has been reported to be less toxic than other steroids, some clinical investigators suggest that it is best used for short-term therapy.
VerwendenBetamethasone is a glucocorticoid used as an anti-inflammatory agent.
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