Dezocine
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Grundinformationen
- CAS
53648-55-8- Standard-SMILES
C[C@@]12CCCCC[C@@H](Cc3ccc(O)cc31)[C@@H]2N- InChIKey
VTMVHDZWSFQSQP-VBNZEHGJSA-N- Summenformel
- C16H23NO
- Durchschnittliche Molmasse
- 245,366 g/mol
- Monoisotopische Masse
- 245,17796436
Namen und Bezeichner
- Bevorzugter Name
- Dezocine
- IUPAC
- (5R,11S,13S)-13-Amino-5-methyl-5,6,7,8,9,10,11,12-octahydro-5,11-methanobenzo[10]annulen-3-ol
- Englischer Name
- Dezocine
- Summenformel
- C16H23NO
- Molmasse
- 245.36
Namen und Synonyme
DalganWy-16225dezocineWy-16225VDeszocineDezocine USP/EP/BP13-Amino-5,6,7,8,9,10,11,12-octahydro-5-methyl-5,11-methanobenzocyclodecen-3-ol(13S)-13-Amino-5,6,7,8,9,10,11,12-octahydro-5-methyl-5α,11α-methanobenzocyclodecen-3-ol(5R,11S,13S)-13-AMino-5-Methyl-5,6,7,8,9,10,11,12-octahydro-5,11-Methanobenzo[10]annulen-3-ol5,11-Methanobenzocyclodecen-3-ol,13-amino-5,6,7,8,9,10,11,12-octahydro-5-methyl-, (5R,11S,13S)-
Datenbank-Bezeichner
- CAS
53648-55-8- PubChem CID
- 3033053
- DTXSID
DTXSID2022911- ChEMBL
CHEMBL1685- ChEBI
CHEBI:4474- UNII
- VHX8K5SV4X
- Nikkaji
- J10.888J
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 124 °C · >124°C (dec.)
- Siedepunkt
- 392.6 · 392.6±42.0 °C(Predicted)
- Dichte
- 1.082 · 1.082±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C · Hygroscopic, -20°C Freezer, Under inert atmosphere
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly)
- pka
- 10.06 · 10.06±0.40(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- ridadr
- 3249
- hazard_class
- 6.1(b)
- packing_group
- III
Chemie und Industrie
Anwendungen
BeschreibungDezocine is an injectable agonisthtagonist analgesic indicated when an opioid analgesic is suitable for the management of pain. The drug differs from other opioid agonisthtagonists by having a high affinity for both the mu and delta receptors and a low effect on kappa receptors. Dezocine is reported to have a rapid onset of action, short half-life and low abuse potential with insignificant side effects.
VerwendenDezocine is an opioid analgesic that is related to Pentazocine (P274300). Dezocine is used to relieve post-operative pain with its potency comparable to Meperidine (M223900).
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
Ergänzende Hinweise
DefinitionChEBI: (7S,8S)-7-Amino-8-methyl-5,6,7,8-tetrahydronaphthalen-2-ol in which the hydrogen at position 8 and one of the hydrogens at position 6 are substituted by each end of a tetramethylene bridge. A synthetic opioid analgesic, it has mixed opiod agonist and antagonist properties. Although it is used for pain management, it can produce opioid withdrawal syndrome in patients already dependent on other opioids, and its clinical application is limited by side effects such as dizziness.
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