HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Fraxinol
Fraxil · FRAXINOL · Fraxinol-RM · Fraxinol (Standard) · Fraxinol, 10 mM in DMSO · 5,7-Dimethoxy-6-hydroxycoumarin · 6-Hydroxy-5,7-dimethoxycoumarin · 6-Hydroxy-5,7-dimethoxy-chromen-2-one
Identifikatoren & physikalische Daten
| CAS No. | 486-28-2 |
|---|---|
| Summenformel | C11H10O5 |
| Durchschnittliche Molmasse | 222,196 g/mol |
| Monoisotopische Masse | 222,05282342 g/mol |
| SMILES | COc1cc2oc(=O)ccc2c(OC)c1O |
| InChIKey | PBPNOAHYDPHKFH-UHFFFAOYSA-N |
| PubChem CID | 3047739 |
| ChEMBL | CHEMBL611349 |
| ChEBI | CHEBI:228872 |
| EC No. | 110-078-9 |
| DTXSID | DTXSID30197558 |
Chemische & physikalische Eigenschaften
| Schmelzpunkt | 170-172℃ |
|---|---|
| Siedepunkt | 449.7±45.0 °C(Predicted) |
| Dichte | 1.358 |
| Lagerbedingungen | Store at -20°C |
| Löslichkeit | Soluble in DMSO and methanolslightly soluble in water |
| pKa (Säurekonstante) | 8.95±0.20(Predicted) |
| Aggregatzustand | powder |
| Farbe | White-yellowish |
| Hauptanwendungen | food and beverages |
| InChI | 1S/C11H10O5/c1-14-8-5-7-6(3-4-9(12)16-7)11(15-2)10(8)13/h3-5,13H,1-2H3 |
| InChIKey | PBPNOAHYDPHKFH-UHFFFAOYSA-N |
| SMILES | [o]1c2c(c(c(c(c2)OC)O)OC)cc[c]1=O |
| CAS Datenbank | 486-28-2 |
Sicherheit & Vorschriften
| Wassergefährdungsklasse (WGK) | WGK 3 |
|---|---|
| Lagerklasse | 11 - Combustible Solids |
| Gefahrenklasse | Acute Tox. 4 Oral |
Anwendungen & Verwendung
Beschreibung
Fraxinol is a coumarin originally isolated from Ash tree bark. It inhibits growth of GLC-4 small cell lung carcinoma and COLO 320 colorectal cancer cells (IC50s = 193 and 165 μM, respectively). Fraxinol potentiates barbiturate-induced sleep in rats and rabbits.