Mercaptomerinnatrium

Letorin · Thiomerin sodium · Diucardyn sodium · mercaptomerin sodium · Mercaptomerine sodique · [[3-[[(3-Sodiooxycarbonyl-2,2,3-trimethylcyclopentyl)carbonyl]amino]-2-methoxypropyl]mercurio(II)thio]acetic acid sodium salt · Mercurate(2-), [3-[[(3-carboxylato-2,2,3-trimethylcyclopentyl)carbonyl-κO]amino]-2-methoxypropyl-κC][2-(mercapto-κS)acetato(2-)-κO]-, sodium (1:2), (T-4)-

https://huagongshe.com/de/chemical/30556

Molekülstruktur von Mercaptomerinnatrium

Identifikatoren & physikalische Daten

CAS No.	21259-76-7
Summenformel	C16H25HgNNa2O6S
Durchschnittliche Molmasse	606 g/mol
Monoisotopische Masse	607,09044008 g/mol
SMILES	COC(CNC(=O)C1CCC(C)(C(=O)[O-])C1(C)C)[CH2][Hg][S]CC(=O)[O-].[Na+].[Na+]
InChIKey	RQXWFEXQGWCOGQ-UHFFFAOYSA-K
PubChem CID	30556
EC No.	244-298-2
DTXSID	DTXSID801016486
Lokaler Name	Mercaptomerinnatrium

Chemische & physikalische Eigenschaften

Polarare Oberfläche (TPSA)	144
H-Brücken-Donoren	1
H-Brücken-Akzeptoren	7
Frei drehbare Bindungen	7
Schwere Atome	27
Formalladung	0
Komplexität	504
Schmelzpunkt	150-155 °C (decomp)
CAS Datenbank	21259-76-7

Sicherheit & Vorschriften

Minimum Risk Level	Chronic Inhalation: 0.0002 mg/m3 (L134)
Treatment	Mercury poisoning is treated by immediate decontamination and chelation therapy using DMSA, DMPS, DPCN, or dimercaprol. (A7)
Gesundheitliche Auswirkungen	Mercury mainly affects the nervous system. Exposure to high levels of metallic, inorganic, or organic mercury can permanently damage the brain, kidneys, and developing fetus. Effects on brain functioning may result in irritability, shyness, tremors, changes in vision or hearing, and memory problems. Acrodynia, a type of mercury poisoning in children, is characterized by pain and pink discoloration of the hands and feet. Mercury poisoning can also cause Hunter-Russell syndrome and Minamata disease. (L7)
Expositionspfade	Oral (L7)inhalation (L7)dermal (L7)
Toxizitätsübersicht	High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through alterations in intracellular thiol status, mercury can promote oxidative stress, lipid peroxidation, mitochondrial dysfunction, and changes in heme metabolism. Mercury is known to bind to microsomal and mitochondrial enzymes, resulting in cell injury and death. For example, mercury is known to inhibit aquaporins, halting water flow across the cell membrane. It also inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. Mercury is also believed to inhibit neuronal excitability by acting on the postsynaptic neuronal membrane. It also affects the nervous system by inhibiting protein kinase C and alkaline phosphatase, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. Mercury also produces an autoimmune response, likely by modification of major histocompatibility complex (MHC) class II molecules, self peptides, T-cell receptors, or cell-surface adhesion molecules. (L7, A8, A25, A26)
Signs and Symptoms	Common symptoms include peripheral neuropathy (presenting as paresthesia or itching, burning or pain), skin discoloration (pink cheeks, fingertips and toes), edema (swelling), and desquamation (dead skin peels off in layers). (A5)
Carcinogen Classification	No indication of carcinogenicity (not listed by IARC). (L135)