Phospho-L-tyrosine
Grundinformationen
- CAS
21820-51-9- Standard-SMILES
N[C@@H](Cc1ccc(OP(=O)(O)O)cc1)C(=O)O- InChIKey
DCWXELXMIBXGTH-QMMMGPOBSA-N- Summenformel
- C9H12NO6P
- Durchschnittliche Molmasse
- 261,17 g/mol
- Monoisotopische Masse
- 261,04022373
Überblick
O(4)-phospho-L-tyrosine is a non-proteinogenic L-alpha-amino acid that is L-tyrosine phosphorylated at the phenolic hydroxy group. It has a role as an immunogen and an Escherichia coli metabolite. It is a L-tyrosine derivative, an O(4)-phosphotyrosine and a non-proteinogenic L-alpha-amino acid. It is a conjugate acid of an O(4)-phosphonato-L-tyrosine(2-). It is an enantiomer of an O(4)-phospho-D-tyrosine.
Namen und Bezeichner
- Bevorzugter Name
- Phospho-L-tyrosine
- IUPAC
- (2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid
- Englischer Name
- O-Phospho-L-tyrosine
- Summenformel
- C9H12NO6P
- Molmasse
- 261.17
Namen und Synonyme
21820-51-9PhosphonotyrosinePHOSPHOTYROSINEPhospho-L-tyrosine2R86C98KDXDTXSID00176234L-Tyrosine, dihydrogen phosphate (ester)(2S)-2-amino-3-[4-(phosphonooxy)phenyl]propanoic acid(2S)-2-amino-3-(4-(phosphonooxy)phenyl)propanoic acidtyrosine-o-phosphateTyrosine O phosphateRefChem:863006
Weitere Namen anzeigen
p-TyrH-TYR(P)-OHPhospho-TyrH-Tyr(PO3)-OHH-TYR(PO3H2)-OHL-Tyr(H2PO3)-OHH-L-Tyr(PO3H2)-OH
DTXCID9098725O-Phospho-L-tyrosineO-PhosphotyrosineH-Tyr(H2PO3)-OHL-Tyrosine-O-phosphateTyrosine O-phosphateO-phosphono-L-tyrosineL-Phosphotyrosine
Datenbank-Bezeichner
- CAS
21820-51-9- PubChem CID
- 30819
- DTXSID
DTXSID00176234
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- -2,8
- Polarare Oberfläche (TPSA)
- 130 Ų
- H-Brücken-Donoren
- 4
- H-Brücken-Akzeptoren
- 7
- Frei drehbare Bindungen
- 5
- Schwere Atome
- 17
- Formalladung
- 0
- Komplexität
- 309
Experimentelle und physikochemische Eigenschaften
Chemical ClassesBiological Agents -> Amino Acids and Derivatives
DrugsPharmaceuticals -> Listed in ZINC15
Physical Description
White solid; [Sigma-Aldrich MSDS]
Solid
Collision Cross Section149.33 Ų [M+Na-2H]- [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]
Physikochemische Eigenschaften
- Schmelzpunkt
- 226 · 226-227°C
- Siedepunkt
- 521.7 · 521.7±60.0 °C(Predicted)
- Dichte
- 1.591 · 1.591±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C · Sealed in dry,Store in freezer, under -20°C
- Löslichkeit
- Aqueous Acid (Slightly), Water (Slightly, Sonicated)
- Aggregatzustand
- Solid
- pka
- 1.24 · 1.24±0.30(Predicted)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for 100% (2 of 2) of all reports.
Not Classified
Aggregated GHS information provided per 2 reports by companies from 1 notifications to the ECHA C&L Inventory.
Gefahrenhinweise
Regulatory InformationStatus: Active Update: 04-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/34754
Hazards SummaryMay cause irritation; [Sigma-Aldrich MSDS]
Hazard Classes and CategoriesNot Classified
Sicherheitsdaten
- F
- 10-21
- wgk
- 3
- hs_code
- 29225090
- risk_code
- 21/22
- hazard_code
- Xn
- safety_code
- 36/37
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Verwendung und Herstellung
UsesAmino acid found in endogenous proteins; [ChemIDplus]
Anwendungen
VerwendenO-Phospho-L-tyrosine is used in the study of tyrosine-phosphorylation, which has been linked to the malignant transformation of cells by various RNA tumor viruses. Plays a role in signal transduction.
Ergänzende Hinweise
DefinitionChEBI: A non-proteinogenic L-alpha-amino acid that is L-tyrosine phosphorylated at the phenolic hydroxy group.
Zugehörige Reaktionen
3
Notizen zur Verbindung
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