2-[[3-(1,3-Dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]benzoic acid
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Grundinformationen
- CAS
325850-81-5- Standard-SMILES
O=C(O)c1ccccc1SCCCN1C(=O)c2cccc3cccc(c23)C1=O- InChIKey
GMVZUCHUOYUMLL-UHFFFAOYSA-N- Summenformel
- C22H17NO4S
- Durchschnittliche Molmasse
- 391,448 g/mol
- Monoisotopische Masse
- 391,08782902
Namen und Bezeichner
- Bevorzugter Name
- 2-[[3-(1,3-Dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]benzoic acid
- IUPAC
- 2-{[3-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propyl]sulfanyl}benzoic acid
- Englischer Name
- 2-[3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-propylsulfanyl]-benzoic acid
- Summenformel
- C22H17NO4S
- Molmasse
- 391.44
Namen und Synonyme
GRI977143GRI977143GRI-977143GRI977143, 10 mM in DMSO2-[[3-(1,3-Dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]-benzoic acid2-((3-(1,3-Dioxo-(1H)benzo[de]isoquinolin-2(3H)-yl)propyl)thio)benzoic AcidBenzoic acid, 2-[[3-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]-2-[3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-propylsulfanyl]-benzoic acid2-((3-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propyl)thio)benzoic acid , GRI977143
Datenbank-Bezeichner
- CAS
325850-81-5- PubChem CID
- 3114900
- DTXSID
DTXSID801148508- ChEMBL
CHEMBL3322500- ChEBI
CHEBI:139224- UNII
- M3L07R4ZEP
- EC Number
- 803-533-4
- Nikkaji
- J3.167.969I
Eigenschaften
Physikochemische Eigenschaften
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- 10 mg/mL, · DMSO: soluble10mg/mL, clear
- Aggregatzustand
- powder
- Farbe
- white to light brown
- InChI
- 1S/C22H17NO4S/c24-20-16-9-3-6-14-7-4-10-17(19(14)16)21(25)23(20)12-5-13-28-18-11-2-1-8-15(18)22(26)27/h1-4,6-11H,5,12-13H2,(H,26,27)
- InChIKey
- GMVZUCHUOYUMLL-UHFFFAOYSA-N
- SMILES
- S(CCC[n]2[c](c3c4c([c]2=O)cccc4ccc3)=O)c1c(cccc1)C(=O)O
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- ridadr
- UN 3077 9 / PGIII
- risk_code
- 22-43-50/53
- hazard_code
- Xn,N
- safety_code
- 36/37-60-61
- Speicherklasse
- 11 - Combustible Solids
- Hazard Classifications
- Acute Tox. 4 OralAquatic Acute 1Aquatic Chronic 1
Chemie und Industrie
Anwendungen
BeschreibungGRI-977143 is an agonist of G protein-coupled lysophosphatidic acid receptor 2 (LPA2) with an EC50 value of 3.3 μM in LPA2-transfected RH7777 cells. It is selective for LPA2, having no activity at LPA1, LPA3, LPA4, and LPA5 at concentrations up to 10 μM. GRI-977143 increases growth and reduces caspase-3 and -7 activation in LPA2-transduced MEF fibroblasts. It increases MM1 rat hepatoma cell invasion and inhibits apoptosis of IEC-6 cells induced by TNF-α, doxorubicin , or serum withdrawal. GRI-977143 also rescues apoptotic cells from γ-irradiation-induced injury in vitro and in vivo.
Verwenden2-[3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-propylsulfanyl]-benzoic acid is used as a non-lipid agonist of LPA2. LPA (Lipoprotein Associated Phospholipase A2/A3 are important factors in prediction of diseases involving fatty acids such as coronary heart disea se or atherosclerosis.
Anbieter27 Anbieter
陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
南京林叶化学试剂有限公司13376084917 13376082704 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
江苏艾康生物医药研发有限公司025-5885952 15955137747 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
BOC Sciences1-631-485-4226; 16314854226 · [email protected]
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