3-Phenylpropan-1-ol

Special hazards arising from the substance or mixture: Carbon oxides

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self contained breathing apparatus for fire fighting if necessary.

Extinguishing Methods: alcohol resistant fire fighters foam.

Wear self contained breathing apparatus for fire fighting if necessary.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Environmental precautions: Do not let product enter drains.

Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging: Dispose of as unused product.

Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Normal measures for preventive fire protection.

Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Body Protection: Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Skin protection: Handle with gloves.

Eye/face protection safety: Use glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 71(SRC), determined from a structure estimation method(2), indicates that 3-phenylpropanol is expected to have high mobility in soil(SRC). Volatilization of 3-phenylpropanol from moist soil surfaces is not expected to be an important fate process(SRC) given a measured Henry's Law constant of <5.6X10-8 atm-cu m/mole(3). Even though the extrapolated vapor pressure is low environmentally at standard temperature and pressure, 0.0234 mm Hg at 25 °C(5), there is a detectable odor; therefore, 3-phenylpropanol may volatilize from dry soil(SRC). Utilizing the Zahn-Wellens test, 100% biodegradation was reached in 4 days(6) indicating that biodegradation is an important environmental fate procession soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 71(SRC), determined from a structure estimation method(2), indicates that 3-phenylpropanol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon a measured Henry's Law constant of <5.6X10-8 atm-cu m/mole(4). According to a classification scheme(5), an estimated BCF of 4.5(SRC), from its log Kow of 1.88(6) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Utilizing the Zahn-Wellens test, 100% biodegradation was reached in 4 days(7) indicating that biodegradation is an important environmental fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 3-phenylpropanol, which has an extrapolated vapor pressure of 0.0234 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 3-phenylpropanol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 1.4 days(SRC), calculated from its rate constant of 1.2X1-11 cu cm/molecule-sec at 25 °C(SRC) (that was derived using a structure estimation method(3). 3-Phenylpropanol does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

3-Phenylpropanol was detected in the skin and pulp of Queen Anne's pocket melon (Cucumis melo var. dudaim (L.) Naudin) at respective concentrations of 365.3 and 216.5 ug/kg(1). 3-Phenylpropanol is reportedly found in heated blackberry, rum, and white wine(2).

IDENTIFICATION AND USE: 3-Phenylpropanol is a colorless liquid. It smells like hyacinths and tastes similar to apricot. It occurs in many fruits and berries, cinnamon and some types of balsam. 3-Phenylpropanol occurs in tobacco smoke. 3-Phenylpropanol is typically used as a perfume for applications such as antiperspirants, creams-lotions, lipsticks, talcum powder, tablet soap, shampoo, hair conditioner, bath/shower gel, detergent powder, liquid detergent, fabric softener, candles, incense. Also used in blossom compositions for balsamic and oriental notes. It is not registered for current pesticide use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses. HUMAN EXPOSURE AND TOXICITY: In a multicenter study, 218 fragrance sensitive patients with proven contact dermatitis were patch tested. Reactions (0.9%) in fragrance sensitive patients were observed with 3-phenylpropanol at 5% in petrolatum. ANIMAL STUDIES: In rats dosed orally with 3-phenylpropanol at dose levels of 1.31, 2.56 and 5.0 g/kg/bw deaths occurred within the first 2 days. The clinical signs observed were slight lethargy and flaccid muscle tone. In a preliminary screen for an acute oral toxicity study, a 50% solution of 3-phenyl-1-propanol in corn oil was administered orally to 10 rats at a dose level of 5 g/kg bw, nine (9/10) rats died. In another study, rats were dosed orally with a 50% solution of 3-phenylpropanol in corn oil at dose levels of 1.47, 2.15, 3.16 and 4.64 g/ kg bw. One death occurred at 1.47 g/kg; and at 2.15 and at 4.64 g/kg. The clinical signs observed during the study were depression, hypopnea, ataxia and piloerection. Gross observations at necropsy revealed dark red areas in the lungs at the three lower doses and dark red lungs at the highest dose. In an irritation study in rabbits 3-phenylpropanol was applied for 24 hr under occlusion at dose levels of 2.5 and 5 g/kg. At 2.5 g/kg, moderate erythema and slight to moderate edema were observed. At 5 g/kg, moderate to severe erythema and moderate edema were observed. In another study in rabbits, 3-phenyl-1-propanol was applied for 24 hr under occlusion at 5 g/kg. Moderate to severe erythema, severe edema, scaling and necrosis were observed. A 0.5 mL aliquot of 3-phenylpropanol was applied to intact and abraded skin for 24 hr under occlusion. Moderate irritation was observed. Necrosis was also observed. No mutagenic or genotoxic activity in bacteria and mammalian cell line assay was found.

3-Phenylpropanol is reportedly found in bilberry (Vaccinium myrtillus L.), high bush blueberry (Vaccinium corymbosumL.), European cranberry (Vaccinium oxycoccus L.), guava fruit (Psidium guajava L.), guava peel, fresh blackberry, shittake (Lentinus edodes Sing.), matsutake (Tricholoma matsutake), peated malt, loquat (Eriobotyra japonica Lindl.), sapodilla fruit (Archras sapota L.), and crowberry (Empetrum nigrum Coll.)(1).

3-Phenylpropanol detections in plants(1).[Table#8251]

Using a structure estimation method based on molecular connectivity indices(1), the Koc of 3-phenylpropanol can be estimated to be 71(SRC). According to a classification scheme(2), this estimated Koc value suggests that 3-phenylpropanol is expected to have high mobility in soil.

/HUMAN EXPOSURE STUDIES/ Closed patch tests were conducted on 82 patients with 0.05- 0.5% 3-phenyl-1-propanol in a base cream or in 99% ethanol. Patches consisted of a piece of 1.0 sq cm lint with a 2.0 sq cm cellophane disc placed on the lint and covered with a 4.0 sq cm plaster. Patches were applied to the back, the forearm and the inside of the upper arm for 24-48 hr. Reactions were read 30 min after patch removal. No reactions were observed.

/HUMAN EXPOSURE STUDIES/ In a multicenter study, 218 fragrance sensitive patients with proven contact dermatitis were patch tested with various fragrance materials according to internationally accepted criteria. Reactions (0.9%) were observed with 5% 3-phenyl-1-propanol in petrolatum.

/HUMAN EXPOSURE STUDIES/ A maximization test was carried out with 8% 3-phenyl-1-propanol in petrolatum on 25 healthy (17 female/8 male) volunteers. Application was under occlusion to the same site on the forearms or backs of all subjects for five alternate-day 48 hr periods. Patch sites were pretreated for 24 hr with 2.5% aqueous sodium lauryl sulfate (SLS) under occlusion. Following a 10 day rest period, challenge patches were applied to fresh sites for 48 hr under occlusion. Challenge sites were pretreated with aqueous SLS. Reactions to the challenge were read at patch removal and 24 hr thereafter. No sensitization reactions were observed.

/HUMAN EXPOSURE STUDIES/ A human repeated insult patch test was conducted on 50 male and female volunteers. Induction patches with 3-phenyl-1-propanol at 4% in petrolatum, were applied for 24 hr under occlusion to the upper arm 3 days a week (Monday/ Wednesday/ Friday) for a total of 15 applications. A 2 week rest period followed the last induction application, followed by a 24 hr challenge patch at the same skin site. The challenge site was read at patch removal, and 24 and 48 hr thereafter. No reactions were produced.

/HUMAN EXPOSURE STUDIES/ Irritation was evaluated during the induction phase of a human repeated insult patch test (HRIPT) which was conducted on 50 healthy volunteers. 3-Phenyl-1-propanol at 4% in petrolatum was applied to a 3 sq cm patch, which was then applied to the upper arm of each volunteer for 24 hr under occlusion. A total of 15-24 hr applications were made. Reactions were read at patch removal. No irritation was observed.

3-Phenylpropanol's production and use in the synthesis of flavor and fragrance compounds(1), as a flavoring agent in foods(2) and as a preservative in cosmetics(3) may result in its release to the environment through various waste streams(SRC). Its use as a perfume(1,2) may result in its direct result to the environment(SRC). 3-Phenylpropanol has been identified as a component of tobacco smoke(4).

AEROBIC: Using the static Zahn-Wellens test, 3-phenylpropanol was determined to be biodegradable based on 100% biodegradation over a 4-day incubation period(1). 3-Phenylpropanol had a 5-day theoretical BOD of 76.8% using a sewage inoculum and a respirometric dilution method(2).

An estimated BCF of 4.5 was calculated in fish for 3-phenylpropanol(SRC), using a log Kow of 1.88(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).