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Hydrogenperoxid-Harnstoff

Carbamide Peroxide

HCID 31294
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Grundinformationen

CAS
124-43-6
Standard-SMILES
NC(N)=O.OO
InChIKey
AQLJVWUFPCUVLO-UHFFFAOYSA-N
Summenformel
CH4N2O.H2O2
Durchschnittliche Molmasse
94,07 g/mol
Monoisotopische Masse
94,03784206

Überblick

Urea hydrogen peroxide appears as a solid or paste-like semisolid. Used to make plastics.

Namen und Bezeichner

Bevorzugter Name
Carbamide Peroxide
IUPAC
hydrogen peroxide;urea
Lokaler Name
Hydrogenperoxid-Harnstoff
Englischer Name
Urea hydrogen peroxide
Summenformel
CH6N2O3
Molmasse
94.07

Namen und Synonyme

CARBAMIDE PEROXIDEUrea hydrogen peroxide124-43-6PercarbamideUrea peroxideUrea dioxideUrea hydroperoxideHydroperitHydroperitePercarbamidHyperolOrtizon
Weitere Namen anzeigen
UHPUREA HYDROGEN PEROXIDE ADDUCTUREA HYDROGEN PEROXIDE ADDITION COMPOUND
PerhydritThenardolPerhydrol-UreaHydrogen peroxide ureaHydrogen peroxide carbamideMurine Ear DropsDebroxGly-oxide

Datenbank-Bezeichner

CAS
124-43-6、14479-85-7
PubChem CID
31294
DTXSID
DTXSID9024726
ChEMBL
CHEMBL3184026
ChEBI
CHEBI:75178
UNII
31PZ2VAU81
EC Number
204-701-4

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
110 Ų
H-Brücken-Donoren
4
H-Brücken-Akzeptoren
3
Frei drehbare Bindungen
0
Schwere Atome
6
Formalladung
0
Komplexität
29

Experimentelle und physikochemische Eigenschaften

Chemical ClassesOther Classes -> Peroxides, Organic
CosmeticsOxidising
Density · 2 Einträge

0.8 at 68 °F (USCG, 1999) - Less dense than water; will float

0.8 @ 20°C

Solubilitygreater than or equal to 100 mg/mL at 68 °F (NTP, 1992)
Human DrugsBreast Feeding; Lactation; Peroxides
Melting Point · 2 Einträge

167 to 185 °F (decomposes) (NTP, 1992)

75-85

Physical Description · 2 Einträge

Urea hydrogen peroxide appears as a solid or paste-like semisolid. Used to make plastics.

White solid; [Merck Index] Solid or paste-like semisolid; [CAMEO] Odorless; [CHRIS] White tablet; [Sigma-Aldrich MSDS]

Autoignition Temperaturegreater than 680 °F (USCG, 1999)

Physikochemische Eigenschaften

Sicherheit und Regulatorisches

Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.

GHS-Klassifizierung

GHS Classification · 6 Einträge

Danger

H272 (94.9%): May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]

P210, P220, P260, P264, P264+P265, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P332+P317, P362+P364, P363, P370+P378, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 59 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

H272: May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]

Gefahrenhinweise

Regulatory Information · 4 Einträge

Chemical: Urea, compound with hydrogen peroxide (H2O2) (1:1)

REACH registered substance: Hydrogen peroxide-urea (EC: 204-701-4)

Urea, compd. with hydrogen peroxide (1:1): HSNO Approval: HSR001360 Approved with controls

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Other Safety InformationIMAP assessments - Urea, compound with hydrogen peroxide (H2O2) (1:1): Human health tier II assessment
DOT LabelOxidizer Corrosive
Fire Hazards · 2 Einträge

Special Hazards of Combustion Products: Irritating ammonia gas may be formed in fire.

CAUTION: Ammonium nitrate products may explode if involved in fire or contaminated with hydrocarbons (fuels), organic matter, other contaminants or when hot molten and contained. Treat as an explosive (GUIDE 112).

Health Hazards

Chemie und Industrie

Pharmakologische Informationen

Protein BindingNo established pharmacokinetic data.
Pharmacodynamics · 1 Eintrag

Carbamide peroxide releases hydrogen peroxide and free radicals upon contact with water or outer surfaces of ear and tooth. Hydrogen peroxide exerts cerumenolytic, enamel-bleaching and antiseptic actions. _In vitro_, the chemical stability of ceramics against bleaching agents was observed after treatment with 15% carbamide peroxide for 56 h, 16% carbamide peroxide for 126 h, 10% or 15% carbamide peroxide and 38% hydrogen peroxide for 30 minutes or 45 minutes, respectively. According to _in vitro_ studies, high (37%) or low (10 or 16%) concentrated carbamide peroxide agents were similarly effective as oral bleaching agents. Treatment with carbamide peroxide may lead to demineralization which involves decreased mineral content of enamel calcium, phosphate, and fluoride, and alteration of the chemical, structural, and mechanical properties. Carbamide peroxide may affect the organic components of the enamel and lead to increased susceptibility to erosion, fracture stability or decreased abrasion resistance of the treated area.

Mechanism of Action · 1 Eintrag

Carbamide peroxide release hydrogen peroxide upon contact with teeth, which is a strong oxidizing and bleaching agent. It also release free radicals such as H+ or H3O+. Hydrogen peroxide also acts as an antiseptic, especially in sites with relative anaerobiosis. Following otic administration, carbamide peroxide complex releases hydrogen peroxide that breaks up the hardened wax. The hydrogen peroxide component, which further breaks down into water, is also a cerumenolytic that hydrates the desquamated sheets of corneocytes, which are the major constituent of cerumen plugs. The glycerol and urea facilitates softening of the cerumen, either with or without syringing. Both hydrogen peroxide and urea mildly induce keratolysis with disintegration of the ear wax to help reduce the keratin-load in the ear debris and allow other active components to reach the skin under the debris.

Biological Half-LifeNo established pharmacokinetic data.
Metabolism/MetabolitesNo established pharmacokinetic data.

Zugehörige Reaktionen

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Schmelzpunkt
90 · 90-93 °C (lit.)
Siedepunkt
175.5 °C · 175.5°C (rough estimate)
Dampfdruck
23.3 mm · 23.3 mm Hg ( 30 °C)
Brechungsindex
1.4616 · 1.4616 (estimate)
storage temp.
15 °C · Store at +15°C to +25°C.
Löslichkeit
2 O: · H2O: 0.5 g/mL, clear to very faintly hazy
Aggregatzustand
tablets
Farbe
White
PH
6.3 · 6.3 (H2O, 20℃)
Wasserlöslichkeit
500 g/L · 500 g/L (20 ºC)
Merck
14 · 14,1782
BRN
3680414 · 3680414
Stabilität
Unstable. Oxidizer. Severe explosion hazard on exposure to shock or heat. Incompatible with strong oxidizing agents, organic materials, reducing agents, finely powdered metals. May form explosive solutions with ether or propanone.
Kosmetik-Inhaltsstoffe Funktionen
OXIDISING
InChI
1S/CH4N2O.H2O2/c2-1(3)4;1-2/h(H4,2,3,4);1-2H
InChIKey
AQLJVWUFPCUVLO-UHFFFAOYSA-N
SMILES
OO.NC(N)=O
LogP
0.09 at · 0.09 at 25℃
CAS Datenbank
124 · 124-43-6(CAS DataBase Reference)
EPA chemische Informationen
Carbamide peroxide (124-43-6)
· 2 Einträge

Inhalation of dust causes irritation of nose from hydrogen peroxide formed when heated. Contact with eyes causes severe damage. Contact with moist skin causes temporary itching or burning sensation. Ingestion causes irritation of mouth and stomach. (USCG, 1999)

· Inhalation, ingestion or contact (skin, eyes) with vapors or substance may cause severe injury, burns or death.

Hazards Summary · 1 Eintrag

Decomposed by air into urea, oxygen, and water; [Merck Index] A strong oxidizer that may combust on heating or on contact with organic substances; [CAMEO] Forms hydrogen peroxide solution on contact with water; An irritant that may cause severe eye injury; [CHRIS] Serious explosion hazard from shock or heat; An irritant that may cause corneal damage and skin blistering; [NTP] An oxidizer that may intensify fire; Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; [Sigma-Aldrich MSDS] See Hydrogen peroxide.

DOT ID and Guide1511 140
Reactive GroupAmides and Imides
Reactivity AlertsStrong Oxidizing Agent
Reactivity Profile · 1 Eintrag

UREA HYDROGEN PEROXIDE is an oxidizing agent. Liable to spontaneous combustion when heated or in contact with organic materials. The contents of a screw-capped brown glass bottle spontaneously erupted after four years storage at ambient temperature. [MCA Case History No. 719]. Combustion may release Irritating ammonia gas.

DOT Hazard Classification · 5 Einträge

Urea hydrogen peroxide

UN1511

Div 5.1 Oxidizer (49 eCFR § 173.127)

Div 5.1 Oxidizer (49 eCFR § 173.127)

PG III: the degree of danger presented by the material is minor

Air and Water ReactionsDecomposed by moisture at about 40 °C to yield a solution of hydrogen peroxide (nonhazardous reaction). Water soluble.

Sicherheit und Schutzausrüstung

Fire FightingExcerpt from ERG Guide 140 [Oxidizers]:
Accidental Release Measures · 2 Einträge

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep combustibles (wood, paper, oil, etc.) away from spilled material.

First Aid · 2 Einträge

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

General First Aid:

Exposure Control and Personal Protection· Wear positive pressure self-contained breathing apparatus (SCBA).
Nonfire Spill ResponseExcerpt from ERG Guide 140 [Oxidizers]:
Isolation and Evacuation · 2 Einträge

Excerpt from ERG Guide 140 [Oxidizers]:

Immediate precautionary measure

Protective Action Criteria (PAC) · 3 Einträge

1.2 [mg/m3]

13 [mg/m3]

79 [mg/m3]

Personal Protective Equipment (PPE)Rubber gloves and protective goggles (USCG, 1999)
Emergency Response Planning GuidelinesSmall Fire

Toxikologische Informationen

Adverse EffectsDermatotoxin - Skin burns.
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation

Sicherheitsdaten

F
21
wgk
2
tsca
TSCA listed
ridadr
UN 1511
hs_code
28470000
risk_code
8-34-36/37/38
Toxizität
LD50 orally in Rabbit: > 2000 mg/kg
hazard_code
Xi,C,O
safety_code
26-36-45-36/37/39-17
hazard_class
5.1
packing_group
III
Speicherklasse
5.1B - Oxidizing hazardous materials
Hazard Classifications
Eye Dam. 1Ox. Sol. 3Skin Irrit. 2
MeSH Pharmacological Classification · 2 Einträge

Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects.

Chemicals that are used to oxidize pigments in TEETH and thus effect whitening.

Absorption, Distribution and Excretion · 4 Einträge

Upon treatment into the external auditory canal or the dental cavity, exposure to carbamide peroxide is limited to the intimate contact with the treated area without any systemic absorption.

No established pharmacokinetic data.

No established pharmacokinetic data.

No established pharmacokinetic data.

Verwendung und Herstellung

Uses · 2 Einträge

Used as an antiseptic, cerumenolytic, and dental bleach; [Merck Index] Used to make plastics; [CAMEO] Used for hair bleaching, oxidation of permanent waves, and hair relaxing; [ExPub: EC: SCCP] Used to develop blueprints and for the modification of starches; [NTP]

Using Disinfectants or Biocides [Category: Clean]

Household ProductsInformation on 1 consumer products that contain Urea Peroxide in the following categories is provided:
Use ClassificationCosmetics -> Oxidising
General Manufacturing InformationUrea, compd. with hydrogen peroxide (H2O2) (1:1): ACTIVE
Anwendungen · 1 Eintrag

VerwendenUrea hydrogen peroxide is an antiseptic, disinfectant and bleaching agent used in pharmaceuticals and cosmetics respectively. It is used in the whitening of teeth and relieves minor inflammation of gums, oral mucosal surfaces and lips. It finds application in the preparation of plastics, blue print development and starch modification. In addition to this, it is used as a source of hydrogen peroxide easily handled in the laboratory.

Vor- und nachgelagerte Produkte

Vorgelagerte Rohstoffe

WasserstoffperoxidHarnstoff

Nachgelagerte Produkte

Diphosphoric acid compd. with-piperazine (1:1)PHOSPHATE STANDARD3-fluoro-4-nitrobenzaMideTetraeisentris(pyrophosphat)

Ergänzende Hinweise

DefinitionChEBI: A mixture obtained by combining equimolar amounts of hydrogen peroxide and urea.