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HCID 31339Erstellt: 31. Oktober 2026

Sucrosedi(acetat)hexaisobutyrat

SAIB · saib-90 · [6-O-Acetyl-1-O,3-O,4-O-tris(2-methyl-1-oxopropyl)-β-D-fructofuranosyl]-α-D-glucopyranoside 6-acetate 2,3,4-tris(2-methylpropionate) · SAIB-SG · saib100s · SAIB-100 · saib-90ea · SAIB-SG-ET-10

https://huagongshe.com/de/chemical/31339

Molekülstruktur von Sucrosedi(acetat)hexaisobutyrat

Identifikatoren & physikalische Daten

CAS No.126-13-6
SummenformelC40H62O19
Durchschnittliche Molmasse846,9 g/mol
Monoisotopische Masse846,38852974 g/mol
SMILESCC(=O)OC[C@H]1O[C@H](O[C@]2(COC(C)=O)O[C@H](COC(=O)C(C)C)[C@@H](OC(=O)C(C)C)[C@@H]2OC(=O)C(C)C)[C@H](OC(=O)C(C)C)[C@@H](OC(=O)C(C)C)[C@@H]1OC(=O)C(C)C
InChIKeyUVGUPMLLGBCFEJ-SWTLDUCYSA-N
PubChem CID31339
ChEBICHEBI:177717
EC No.204-771-6
Lokaler NameSucrosedi(acetat)hexaisobutyrat

Chemische & physikalische Eigenschaften

XLogP5,3
Polarare Oberfläche (TPSA)238
H-Brücken-Donoren0
H-Brücken-Akzeptoren19
Frei drehbare Bindungen27
Schwere Atome59
Formalladung0
Komplexität1.500
StoffklassenOther Classes -> Other Organic Compounds
KosmetikaCosmetic ingredients (Sucrose Acetate Isobutyrate) -> CIR (Cosmetic Ingredient Review)Film formingPlasticiser
LebensmittelzusatzstoffeFLAVOR ENHANCER, FLAVORING AGENT OR ADJUVANT, PROCESSING AID, SURFACE-FINISHING AGENT -> FDA Substance added to food
Dichte1.146 @ 25 °C/25 °C1.146 g/mL at 25 °C (lit.)
Color/FormCLEAR SEMI-SOLID
Food Contact SubstancesFCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR
Physical DescriptionClear semi-solid or 90% solution in ethanol[Hawley] Light yellow viscous liquid[MSDSonline]
Schmelzpunkt−7 °C (lit.)
Siedepunkt288 °C (lit.)
Dampfdruck40 mm Hg ( 20 °C)
Brechungsindexn 20/D 1.457 (lit.)
FlammpunktNot applicable
Lagerbedingungen2-8°C
AggregatzustandColorless to faint yellow liquid
FarbeColorless to light yellow
GeruchOdorless
Kosmetik-Inhaltsstoffe FunktionenFILM FORMINGPLASTICISER
InChIKeyZNEBZIJCDDCNRC-BDNKQTQWNA-N
SMILESCC(C)C(=O)OC[C@]1(O[C@H](COC(C)=O)[C@@H](OC(=O)C(C)C)[C@@H]1OC(=O)C(C)C)O[C@H]2O[C@H](COC(C)=O)[C@@H](OC(=O)C(C)C)[C@H](OC(=O)C(C)C)[C@H]2OC(=O)C(C)C
LogP (Verteilungskoeffizient)6.619 (est)
EPA chemische Informationen.alpha.-D-Glucopyranoside, 6-O-acetyl-1,3,4-tris-O-(2-methyl-1-oxopropyl)-.beta.-D-fructofuranosyl, 6-acetate 2,3,4-tris(2-methylpropanoate) (126-13-6)

Sicherheit & Vorschriften

GHS-EinstufungThis chemical does not meet GHS hazard criteria for 99.2% (119 of 120) of all reports.Not ClassifiedAggregated GHS information provided per 120 reports by companies from 3 notifications to the ECHA C&L Inventory.
Regulatorische InformationenChemical: .alpha.-D-Glucopyranoside, 6-O-acetyl-1,3,4-tris-O-(2-methyl-1-oxopropyl)-.beta.-D-fructofuranosyl, 6-acetate 2,3,4-tris[2-methylpropanoate]Regulation (EC) No 1333/2008 (amended).alpha.-D-Glucopyranoside, 6-O-acetyl-1,3,4-tris-O-(2-methyl-1-oxopropyl)-.beta.-D-fructofuranosyl, 6-acetate 2,3,4-tris(2-methylpropanoate): Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Weitere SicherheitsinformationenIMAP assessments - .alpha.-D-Glucopyranoside, 6-O-acetyl-1,3,4-tris-O-(2-methyl-1-oxopropyl)-.beta.-D-fructofuranosyl, 6-acetate 2,3,4-tris[2-methylpropanoate]: Environment tier I assessment
GefahrenübersichtCauses muscle weakness and diarrhea in intraperitoneal, lethal-dose studies of rats[RTECS] No affect on liver enzymes in 20 volunteers who ingested 10 mg/kg/day for 14 days[HSDB] May cause mild eye irritation, based on animal studies[MSDSonline]
Special ReportsWHOEnviron Health Criteria Number 32: Toxicological Evaluation of Certain Food Additives and Contaminants (1993)
Hazard Classes and CategoriesNot Classified
EntsorgungsverfahrenSRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
ToxizitätsübersichtSafe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org

Anwendungen & Verwendung

Verwenden

food additive, plasticizer

Human Toxicity ExcerptsTwenty subjects (10 males and 10 females) between 18 and 22 years of age ingested a daily dose of sucrose acetate isobutyrate at a level equivalent to 10 mg/kg bw/day for a period of 14 days. The dose was taken as a bolus each morning. The following blood parameters were measured prior to treatment and at days 7 and 18 of the study: aspartate aminotransferase, alanine aminotransferase, serum alkaline phosphatase, serum bilirubin, total protein, albumin, uric acid, blood area nitrogen, erythrocyte sedimentation rate, sodium, potassium, phosphorous, total CO2, cholesterol and glucose. There were no significant differences in any parameters in any individual ... .In another 14-day study, 12 male and 12 female subjects were divided evenly by sex into 3 groups, receiving a carbonated drink only (controls), or a single daily dose of 7.0 or 20.0 mg sucrose acetate isobutyrate/kg bw/day in a carbonated drink. In addition, four men received 20 mg sucrose acetate isobutyrate/kg bw/day for 1 or 3 days only in a pilot experiment to provide early evaluation of possible alterations in normal hepatic function. The subjects were 21 to 42 years of age. Blood was collected prior to testing and on days 7 and 14 for hematological (platelets, total and differential white blood cells count, erythrocyte sedimentation rate, Hct and hemoglobin) and clinical chemistry (total protein, albumin, A/G ratio, calcium, cholesterol, glucose, blood area nitrogen, uric acid total bilirubin, serum alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase) parameters. Standard urinalysis parameters were also recorded at these times. A 45 minute bromosulfophthalein retention test (5 mg/kg bw bromosulfophthalein was also conducte on all subjects prior to treatment and after completion of treatment. Treatment with sucrose acetate isobutyrate did not affect any of these parameters for any individual ... .Twenty-seven adult subjects, 13 men and 14 women, between the ages of 18 to 55, received sucrose acetate isobutyrate in an aqueous/orange juice emulsion daily for 14 days at a dose of 20 mg/kg bw. In the 7 days prior to treatment, each subject acted as his/her own control by ingesting an orange juice beverage and placebo emulsion. Blood samples were collected from each subject on days -6, 0, 7 and 14 of treatment for measurement of routine hematological and clinical chemistry parameters, including specific indicators of hepatobiliary function (serum alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, gamma-glutamyl transferase, total bilirubin, direct bilirubin, bile acids and serum proteins). No treatment-related changes were detected in any of these parameters over the 14-day dosing period ... .
Non-Human Toxicity Excerpts...95-DAY SUB-ACUTE TOXICITY TESTING OF DOGS & RATS WITH SUCROSE ACETATE ISOBUTYRATE SHOWED IT TO BE WITHOUT EFFECT.Five groups of B6C3F1/Cr1BR mice (10/sex/group) received approx 0, 0.625, 1.25, 2.5 or 5.0 g sucrose acetate isobutyrate/kg bw/day in the diet for 4 wk. Body weights, food consumption and physical exam were recorded at initiation of treatment and weekly during the study. Feeding of sucrose acetate isobutyrate at these doses for 4 wk had no effect on the biological performance of the treated animals. No treatment-related observations were noted at the terminal necropsy ... .A three-week feeding study was conducted in which groups of 30 Sprague-Dawley rats (15/sex/group) were fed 0, 5,000 or 50,000 ppm sucrose acetate isobutyrate in the diet. Five rats/sex/group were sacrificed after 1, 2 and 3 weeks of treatment. Twice weekly determinations of body weight and food consumption indicated no adverse effect of treatment on these parameters. Daily examination of the rats during the first week revealed a high incidence of respiratory disease which was not related to treatmentno animals died. Gross necropsy at sacrifice did not reveal any treatment-related changes. Absolute and relative liver weights were comparable between control and treated groups ... .In a series of studies, Sprague-Dawley rats were divided into 14 treatment groups of 10 animals/sex/group and fed diets containing sucrose acetate isobutyrate at dietary levels of 1.0, 2.0 and 4.0% (w/w) supplemented with 5% corn oil (w/w). The groups were fed the test diets for 28 or 56 days continuously or for 28 days followed or preceded by 28 days on control diet. Two groups were fed the control diet containing corn oil only for 28 or 56 days continuously. At the termination of the study, animals were sacrificed and blood collected for determination of serum alkaline phosphatase (SAP), ornithine carbamyl transferase (OCT), blood urea nitrogen (BUN), triglyceride, cholesterol and glucose. The animals were autopsied, examined grossly, and absolute and relative liver weights were determined. Liver microsomal enzyme activity (p-nitroanisole demethylase), glucose-6-phosphatase and bilirubin-beta-D-glucuronyl transferase were determined and the liver was histologically examined. Weight gain and feed consumption of test and control groups were similar. There were no significant changes in the serum chemistry of the test animals. Gross pathology at autopsy was negative and liver weights (absolute and relative) were similar for test and control groups. Microsomal enzyme activity was similar for test and control animals, with the exception that glucose-6-phosphatase activity was reduced in male rats on the 4% sucrose acetate isobutyrate diet ... .For more Non-Human Toxicity Excerpts (Complete) data for SUCROSE ACETATE ISOBUTYRATE (33 total), please visit the HSDB record page.
Non-Human Toxicity ValuesLD50 Rat oral >5.0 g/kg bw /From table/
Wassergefährdungsklasse (WGK)3
UN-TransportnummerUN 1173 3/PG 2
R-Sätze (R)20/21/22-36/37/38-68/20/21/22-10-52/53-11
Toxizitätmouse,LDLo,intraperitoneal,25600mg/kg (25600mg/kg),GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"BEHAVIORAL: MUSCLE WEAKNESSSKIN AND APPENDAGES (SKIN): HAIR: OTHER,Journal of Agricultural and Food Chemistry. Vol. 21, Pg. 473, 1973.
GefahrensymboleXi,Xn,F
Sicherheitshinweise (S)16-26-36-61
Lagerklasse3 - Flammable liquids
Gefahrstoffdaten126-13-6(Hazardous Substances Data)
GefahrenklasseFlam. Liq. 2