| GHS-Einstufung | WarningH302: Harmful if swallowed [Warning Acute toxicity, oral]P203, P264, P270, P280, P301+P317, P302+P352, P318, P321, P330, P332+P317, P362+P364, P405, and P501 (click each P-code to see the statement)H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P203, P264, P270, P273, P280, P301+P317, P302+P352, P318, P321, P330, P332+P317, P362+P364, P405, and P501 (click each P-code to see the statement) |
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| Regulatorische Informationen | Chemical: Phosphoric acid, tributyl esterHazard Traits - NeurotoxicityPhosphoric acid tributyl ester is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Phosphoric acid tributyl ester are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 21-07-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/13548Tributyl phosphate: Does not have an individual approval but may be used under an appropriate group standard |
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| Weitere Sicherheitsinformationen | IMAP assessments - Phosphoric acid, tributyl ester: Human health tier II assessment |
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| Brandgefahren | Special Hazards of Combustion Products: Toxic fumes of POx. (USCG, 1999)Combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
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| Brandpotenzial | Combustible when exposed to heat or flame. |
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| Gesundheitsgefahren | May cause stimulation of the central nervous system. (USCG, 1999) |
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| Gefahrenübersicht | TLV Basis is bladder, eye, and upper respiratory tract irritationAnimals given repeated oral doses show necrosis, hyperplasia, and subsequent neoplasia of the urinary bladder epithelium with a NOEL of 9-12 mg/kg/day equivalent to a worker exposed by inhalation to 63-84 mg/m3In lethal dose studies, animals have mild anesthesia, pronounced weakness, and respiratory failureIn inhalation studies, serum cholinesterase activity is depressed on the day after exposureNo evidence of nerve damage (OPIDN) in standard protocols testing chickens[ACGIH] If left on clothing, can cause reddening of skin[CHRIS] Irritating to the skin, eyes, and respiratory tract[ICSC] |
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| FDA-Anforderungen | Tributyl phosphate is an indirect food additive for use only as a component of adhesives. |
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| Reaktive Gruppe | Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters |
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| EG-Einstufung | Symbol: XnR: 22-38-40S: (2)-36/37-46 |
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| Special Reports | WHOEnviron Health Criteria 112: Tributyl Phosphate (1991)The U.S. high production volume (HPV) chemicals are those which are manufactured in or imported into the United States in amounts equal to or greater than one million pounds per year. Robust Summaries include health effects, ecotoxicity data, and environment fate information for selected chemicals. EPA/Office of Pollution Prevention and ToxicsHigh Production Volume (HPV) Challenge Program's Robust Summaries and Test Plans.[Available from, as of January 19, 2006: http://www.epa.gov/hpv/pubs/hpvrstp.htm] |
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| TSCA-Anforderungen | Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329. Effective date: 10/29/90Reporting date: 12/27/90.Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Phosphoric acid, tributyl ester is included on this list. Effective date: 06/18/86Sunset date: 06/18/96.All persons who manufacture (including import and byproduct manufacture) or process or intend to manufacture or process TBP /tributyl phosphate/, other than as an impurity, from the effective date of the final rule to the end of the reimbursement period shall submit letters of intent to conduct testing, submit study plans, conduct tests, and submit data, or submit exemption applications as specified in this section, subpart A of this part, and part 790 of this chapter for single-phase rulemaking. Required testing: health effects testing, environmental effects testing and chemical fate testing. |
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| OSHA Standards | Permissible Exposure Limit: Table Z-1 8-hr Time Weighted Avg: 5 mg/cu m.Vacated 1989 OSHA PEL TWA 0.2 ppm (2.5 mg/cu m) is still enforced in some states. |
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| Brandbekämpfung | Fire Extinguishing Agents: CO2, dry chemical, fog, mist (USCG, 1999)Use water spray, foam, powder, carbon dioxide. |
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| Erste-Hilfe-Maßnahmen | Fresh air, rest.Remove contaminated clothes. Rinse skin with plenty of water or shower.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Refer for medical attention . |
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| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.(General first aid procedures) |
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| Sichere Lagerung | Store in an area without drain or sewer access. Separated from bases and strong oxidants. |
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| Firefighting Hazards | Special hazards arising from the substance or mixture: Carbon oxides, Oxides of phosphorus |
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| Expositionsschutz und Persönliche Schutzausrüstung | Biological Exposure Indices (BEI) [ACGIH] - Acetylcholinesterase activity in red blood cells = 70% of individual's baselineButylcholinesterase activity in serum or plasma = 60% of individual's baselineSample at end of shift[TLVs and BEIs]11.0 [mg/m3] |
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| Brandbekämpfungsverfahren | Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.Advice for firefighters: Wear self contained breathing apparatus for fire fighting if necessary.To fight fire use carbon dioxide, dry chemical, fog, mist. |
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| Lagerbedingungen | Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. |
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| Reinigungsverfahren | Accidental release measures. Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.Methods and materials for containment and cleaning up: Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.A study of nuclear fuel reprocessing solvent tributyl phosphate included its degradation and clean-up and disposal of degradation products.Ventilate the area of spill or leak. For small quantities, absorb on paper towel . |
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| Freisetung ohne Brand | Neutralizing Agents for Acids and Caustics: Dry lime or soda ash (USCG, 1999) |
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| Entsorgungsverfahren | SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal and plant lifeand conformance with environmental and public health regulations.Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.Contaminated packaging: Dispose of as unused product.SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal. |
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| Verschüttetes entsorgen | Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable non-plastic containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. |
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| Körperbelastung | In EPA's National Human Monitoring Program's National Human Adipose Tissue Survey, broad scan survey for 1982, tributyl phosphate was detected at 120 ng/g in 1 of 46 composite samples analyzed(1). The sample came from the 0-14 age group of the east north central census region(1). Tributyl phosphate was detected at 10 ppb in plaque from the aorta of one of two autopsied heart attack victims(2). |
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| Wechselwirkungen | A 3.2 fold incr in resorption of (239)Plutonium admin as (239)Pu complex with tributyl phosphate in hexachlorobutadiene was observed during the first 4 days in an experiment on 120 Wistar rats, as compared to the resorption level during the admin (239)Pu alone, greater accumulation in the organs of secondary deposition, followed by the disappearance of differences, but for the kidneys, where the differences were observed until the end of the experiment. These features did not lead to incr of absorbed radiation doses in the critical organs by the end of the study. ...Wistar rats were subjected to a single exposure to (239)Pu nitrate through inhalation with the subsequent procedure of imitation of inhalation or without it (the amount of 23P9Pu deposited in the lungs in 24 hr was 8.9 | 1.9 kBq/lung) and inhalation of hexachlorbutadiene and tributylphosphate within one month in a combination with the radionuclide or without it. There was a 1.5-fold increase, above additive, in the harmful effect of (239)Pu and chemical agents on the function of natural killers as observed 15-30 days after the combined exposure as compared to individual inhalation. On days 120 to 240 cell cytotoxic activity in rats of all groups was normalized to reach or to exceed the intact control.Two-cell mouse embryos were exposed in vitro to tributyl phosphate, x rays, or a combination of both. In-vitro development of the embryos was followed microscopically (cleavage to four- and eight-cell embryos, formation of morulae and blastocysts, and hatching of blastocysts). Effects on proliferation were estimated by counting the number of cells per embryo early (48 h p.c. = 48 hours post conceptionem) and late (144 h p.c.) in the preimplantation period. Cytogenetic damage was studied using micronucleus formation as the end point. Tributyl phosphate did not reveal toxic effects up to a concentration of about 5 microM after an exposure time of 18 h. At a concentration of about 15 microM, 50% of late preimplantation embryos showed effects on morphological development and on cell proliferation, and at about 40 microM, 90% of the embryos were affected. Tributyl phosphate did not induce micronuclei. Small effects by x irradiation were observed between 0.25 Gy and 0.5 Gy, depending on the end point measured in the late preimplantation stage. Fifty percent of the embryos were affected by a dose slightly higher than 1 Gy, and 90% after about 4 Gy. No enhancement in risk was found after combined treatment of the embryos with tributyl phosphate and x rays.It has been established in the experiment on rats exposed to a joint action of plutonium-239, hexachlorobutadiene and ++tributyl phosphate, that manifestations of disturbances from radiation and chemical factors which are more expressed under a joint exposure, are characteristic of the thymus gland damage pattern. As far as lymphocytes count in the organ is concerned, the effect of the joint exposure is no more than additive.... A mixture composed principally of dibutyl phenyl phosphate and tributyl phosphate ... was evaluated in an inhalation toxicity study /using/ Sprague-Dawley rats. Target exposure levels used ... were 0, 5, 100 and 300 mg/cu m, and exposures were maintained for 6 hr/day, 5 days/week. ... The only clinical sign of chemical toxicity was the observation of a reddish nasal discharge with accompanying oral salivation in mid and high exposure animals of both sexes, indicative of an irritant response. Statistically significant reduced body weightsincreased absolute and relative liver weightsand decreased erythrocyte counts, hemoglobin levels, and hematocrit values were observed in high-exposure female rats euthanized after 13 weeks ... exposure. High-exposure male rats also had increased absolute and relative liver weights and decreased hematocrit values after 13 weeks. Plasma cholinesterase levels were decreased in high-exposure female rats both 6 and 13 weeks after the study was initiated. Histopathologic evaluation revealed mild hepatocellular vacuolation in high-exposure male rats and centrilobular hepatocellular hypertrophy in high-exposure female rats. No pathological changes were observed in animals at 100 mg/cu m. ... |
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| Zielorgane | Eyes, skin, respiratory system |
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| Ökotoxizitätswerte | LC50Species: Artemia salina (Brine shrimp)Concentration: 54.6 mg/L for 24 hr (95% confidence limit: 49.9-59.3 mg/L) /Conditions of bioassay not specified in source examined/Species: Carassius auratus (Goldfish)Conditions: staticConcentration: 8.8 mg/L for 96 hr /technical product/EC50Species: Chlorella emersonii (Green algae)Conditions: static, 25 °CConcentration: 10-50 mg/L for 48 hrEffect: inhibition of cell multiplication /from table/Species: Danio rerio (Zebra danio)Concentration: 11.4 mg/L for 96 hr (95% confidence limit: 10.0-13.5 mg/L) /formulated product/For more Ecotoxicity Values (Complete) data for TRIBUTYL PHOSPHATE (24 total), please visit the HSDB record page. |
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| Umweltverhalten | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 2400(SRC), determined from a structure estimation method(2), indicates that tributyl phosphate is expected to have slight mobility in soil(SRC). Volatilization of tributyl phosphate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.4X10-6 atm-cu m/mole(SRC), based upon its vapor pressure, 1.13X10-3 mm Hg(3), and water solubility, 280 mg/L(4). However, adsorption to soil is expected to attenuate volatilization(SRC). Tributyl phosphate is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). Biodegradation of 56-96% in activated sludge inoculum(4) and a 3% of theoretical BOD using activated sludge in the Japanese MITI test(5) suggest that biodegradation may be an important environmental fate process in soil(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 2400(SRC), determined from a structure estimation method(2), indicates that tributyl phosphate is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 1.4X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 1.13X10-3 mm Hg(4), and water solubility, 280 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 40 and 300 days, respectively(SRC). Tributyl phosphate is not expected to undergo hydrolysis in the environment(SRC) due to estimated hydrolysis half-lives of 9.9 to 11.5 years at pH 9 to 5(2). According to a classification scheme(6), BCFs of 5.5-20 in carp(7), 30-35 in killifish and 6-11 in goldfish(8), suggest bioconcentration in aquatic organisms is low to moderate(SRC). Aqueous biodegradation test results for tributyl phosphate varied from negligible biodegradation(9-11) to 30-100% biodegradation(5,11).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tributyl phosphate, which has a vapor pressure of 1.13X10-3 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase tributyl phosphate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 4.4 hours(SRC), calculated from its rate constant of 7.9X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Tributyl phosphate does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). |
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| Lebensmitteluntersuchungswerte | According to FDA Total Diet studies in FY 1980, tributyl phosphate was found only in grain and cereal products composites at concentrations of 0.003-0.080 ppm (avg 0.0086 ppm), 0.003-0.104 ppm (avg 0.0158 ppm), 0.003-0.031 ppm (avg 0.0068 ppm), for infants, toddlers, and adult samples, respectively(1-2). According to FDA Total Diet studies in FY 1981/82, tributyl phosphate was found in grain and cereal products composites at concentrations of 0.003-0.032 ppm (avg 0.0053 ppm), 0.006-0.092 ppm (avg 0.0091 ppm), 0.003-0.060 ppm (avg 0.0091 ppm) for infants, toddlers, and adult samples, respectively and one adult composite of garden fruit at 0.0004 ppm(3-4). In the FDA's Revised Market Basket Study operated from 1982 to 1991, tributyl phosphate was detected 73 times in 25 different foods with an average concentration of 0.0137 ug/g(5). The foods in which it was detected were baby foods (peastomato, beef, and macaronivegetables with turkey or chicken), canned beets, bread (rye, enriched white, whole wheat), cereal (cornflakes, fruit-flavored, crisped rice, oat ring, raisin bran, shredded wheat), cooked corn grits, cooked farina, strawberry gelatin, cooked macaroni, canned, sliced mushrooms, rolled, cooked oats, and sweet, green, raw pepper(5). |
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| Unerwünschte Wirkungen | ACGIH Carcinogen - Confirmed Animal. |
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| Expositionspfade | The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.inhalation, ingestion, skin and/or eye contact |
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| Toxizitätsübersicht | IDENTIFICATION AND USE: Tributyl phosphate is a colorless to pale-yellow odorless liquid. It is used as a plasticizer for cellulose esters, lacquers, plastics, and vinyl resins. Used in fire-resistant aircraft hydraulic fluids. Other uses include heat-exchange medium, solvent extraction of metal ions from solution of reactor products, solvent for nitrocellulose, cellulose acetate, pigment grinding assistant, antifoaming agent, dielectric. HUMAN EXPOSURE AND TOXICITY: Breathing vapors of tributyl phosphate causes irritation of mucous membranes and if inhalation is prolonged there can be general poisoning with paralysis. In contact with skin tributyl phosphate can cause irritation. Tributyl phosphate may cause irritation of the eyes, nose, and throat. It may also cause nausea and headache. In a series of 42 patients with furniture related dermatitis, a positive patch test reaction was seen in 1 patient. In vitro it acts as androgen receptor, and glucocorticoid receptor antagonist. ANIMAL STUDIES: Tributyl phosphate was not acutely toxic by dermal exposure in the rabbit and in the guinea pig. Application to either intact or abraded skin of rabbits and guinea pigs produced irritation with edema and erythema. The instillation of tributyl phosphate in the conjunctival sac of rabbits gave rise to mild irritation. Rats subjected to multiple intragastric administrations of tributyl phosphate showed hyperemia of internal organs and brain. Tributyl phosphate was not neurotoxic to rats, but induced paralysis in mice. Tributyl phosphate did not cause organophosphorus compound-induced delayed neurotoxicity (OPIDN) in the adult hen. Tributyl phosphate produced tumors of the bladder urothelium in rats at high doses, with greater effects in males than in females. It does not produce tumors in mice. The chemical was not teratogenic in rats. In the rabbit, maternal and embryo toxicity were suggested at 400 mg/kg/day with no observations of fetotoxicity or teratogenicity in any dosage group. No mutagenic activity was identified after treatment with tributyl phosphate: when tested in the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) mutation assay in Chinese hamster ovary (CHO) cells, both with and without metabolic activation and when testing in Salmonella typhimurium strains TA98, TA100, TA1535, or TA1537 with or without metabolic activations. Tributyl phosphate did not induce chromosomal damage in rat bone marrow cells. ECOTOXICITY STUDIES: Rainbow trout treated with tributyl phosphate had severe balance disturbances, which included highly atypical movements like darting, coiling swimming, and backward somersaults. At higher concentrations the fish were immobilized, lying on their sides at the bottom of the water, and some of them died. |
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| Average Daily Intake | According to FDA Total Diet studies in fiscal year 1980, daily intakes of tributyl phosphate for infants and children were 0.051 and 0.132 ug/kg body weight(1)for adults, the intake was 0.041 ug/kg body weight (2.85 ug for a 70 kg person)(2). According to FDA Total Diet studies in fiscal year 1981 to 1982, daily intakes of tributyl phosphate for infants and children were 0.020 and 0.075 ug/kg body weight(3)for adults, the intake was 0.055 ug/kg body weight (1.73 ug for a 70 kg person)(4).The US Food and Drug Administration market basket surveys done April 1982-April 1984(1), June 1984-April 1986(2) and July 1986-April 1991(3), found that the average intake of tributyl phosphate (ng/kg body weight/day) for each of the following age groups:[Table#3481] |
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| Ökotoxizitätsauszüge | /AQUATIC SPECIES/ ... Rainbow trout did not show any obvious effects at water concentrations below 5.6 mg tributyl phosphate/L but behaved very calmly when trapped in a hand-net at a concentration of 1 mg/L (all concentrations are nominal value). At 10 mg/L, the fish started showing severe balance disturbances, which included highly atypical movements like darting, coiling swimming, and backward somersaults, but they recovered after 24-72 hr at this concentration. On the other hand, the balance disturbances persisted until the end of the experiment at a concentration of 11.5 mg/L. At 13.5 mg/L, the fish were immobilized, lying on their sides at the bottom of the water, and some of them died. |
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| Animal Concentrations | Tributyl phosphate concentrations were reported in female herring gull (Larus argentatus) tissue and egg components from samples collected Apr 2010 at Lake Huron colony site on Chantry Island(1).[Table#3479] |
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