HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2,3-Dimethoxy-1,4-naphthoquinone
DMNQ · DIMENQ · Nsc 69355 · DMNQ, 10 mM in DMSO · RARECHEM BW GA 0209 · 2,3-DIMETHOXY-1,4-NAPHTHOQUINONE · 2,3-Dimethoxy-1,4-naphthalenedione · 2,3-dimethoxynaphthalene-1,4-dione
Identifikatoren & physikalische Daten
| CAS No. | 6956-96-3 |
|---|---|
| Summenformel | C12H10O4 |
| Durchschnittliche Molmasse | 218,2 g/mol |
| Monoisotopische Masse | 218,0579088 g/mol |
| SMILES | COC1=C(OC)C(=O)c2ccccc2C1=O |
| InChIKey | ZEGDFCCYTFPECB-UHFFFAOYSA-N |
| PubChem CID | 3136 |
| ChEMBL | CHEMBL402468 |
| ChEBI | CHEBI:64215 |
| EC No. | 636-211-5 |
| DTXSID | DTXSID8040935 |
Chemische & physikalische Eigenschaften
| XLogP | 1,9 |
|---|---|
| Polarare Oberfläche (TPSA) | 52,6 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 2 |
| Schwere Atome | 16 |
| Formalladung | 0 |
| Komplexität | 322 |
| Lagerbedingungen | -20°C |
| Löslichkeit | Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 5 mg/ml). |
| Aggregatzustand | solid |
| Farbe | Yellow |
| Stabilität | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| InChI | 1S/C12H10O4/c1-15-11-9(13)7-5-3-4-6-8(7)10(14)12(11)16-2/h3-6H,1-2H3 |
| InChIKey | ZEGDFCCYTFPECB-UHFFFAOYSA-N |
| SMILES | COC1=C(OC)C(=O)c2ccccc2C1=O |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 38 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Hazard Classes and Categories | Skin Irrit. 2 (100%) |
| Wassergefährdungsklasse (WGK) | 3 |
| R-Sätze (R) | 36/37/38 |
| Gefahrensymbole | Xi |
| Sicherheitshinweise (S) | 26-36 |
| Lagerklasse | 11 - Combustible Solids |
| Gefahrenklasse | Eye Irrit. 2Skin Irrit. 2STOT SE 3 |
Anwendungen & Verwendung
Beschreibung
DMNQ is a 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation. The amount of oxidative stress is proportional to the amount of DMNQ applied and can alter diverse cellular parameters, including signal transduction, mitochondrial function, and gene expression.
Verwenden
DMNQ is a non-alkylating redox cycling quinone.