HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Zinkbis(4-hydroxybenzolsulfonat)
4-hy · phenozin · universalzps · caswellno921a · zincsulfophenate · ZINC SULFOCARBOLATE · ZINCSULPHOCARBOLATE · ZINC PHENOLSULFONATE
Identifikatoren & physikalische Daten
| CAS No. | 127-82-2 |
|---|---|
| Summenformel | Zn(C6H5O4S)2 |
| Durchschnittliche Molmasse | 411,7 g/mol |
| Monoisotopische Masse | 409,910851 g/mol |
| SMILES | O=S(=O)([O-])c1ccc(O)cc1.O=S(=O)([O-])c1ccc(O)cc1.[Zn+2] |
| InChIKey | ZNVKGUVDRSSWHV-UHFFFAOYSA-L |
| PubChem CID | 31391 |
| EC No. | 204-867-8 |
| DTXSID | DTXSID1059571 |
| Lokaler Name | Zinkbis(4-hydroxybenzolsulfonat) |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 172 |
|---|---|
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 8 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 23 |
| Formalladung | 0 |
| Komplexität | 194 |
| Stoffklassen | Other Uses -> Biocides/Disinfectants |
| Kosmetika | Cosmetic ingredients (Zinc Phenolsulfonate) -> CIR (Cosmetic Ingredient Review)AstringentDeodorantAntimicrobial |
| pH | Moderate acidity |
| Geruch | Odorless |
| Dichte | greater than 1 at 68 °F (USCG, 1999) |
| Color/Form | Colorless transparent crystals or white granular powder |
| Löslichkeit | Solubility: 62.5 g/100 cc cold water250 g/100 cc water at 100 °C55.6 g/100 cc alcohol at 25 °C /Octahydrate/ |
| Siedepunkt | 248 °F at 760 mmHg (decomposes) (USCG, 1999) |
| Decomposition | When heated to decomposition it emits toxic vapors of /sulfur oxides/ and fumes of /zinc/. |
| Physical Description | Zinc phenolsulfonate appears as a colorless to white crystalline solid which turns pink on exposure to air. The primary is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. It is soluble in water. It is used as an insecticide and in medicine.Octahydrate: Odorless solidEffloresces in dry air[Merck Index] |
| Other Experimental Properties | SPECIFIC GRAVITY: GREATER THAN 1 @ 20 °C /OCTAHYDRATE/ |
| Geruch | at 100.00%. odorless |
| Kosmetik-Inhaltsstoffe Funktionen | ANTIMICROBIALASTRINGENTDEODORANT |
| InChI | InChI=1S/C6H6O4S.Zn/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4,7H,(H,8,9,10) |
| InChIKey | OVKSISLQQUYEAI-UHFFFAOYSA-N |
| SMILES | S(C1C=CC(O)=CC=1)(O)(=O)=O.[Zn] |
| LogP (Verteilungskoeffizient) | -1.670 (est) |
| EPA chemische Informationen | Zinc phenolsulfonate (127-82-2) |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 46.8% (36 of 77) of reports.WarningH302 (53.2%): Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 77 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatorische Informationen | Chemical: Benzenesulfonic acid, 4-hydroxy-, zinc salt (2:1)Benzenesulfonic acid, 4-hydroxy-, zinc salt (2:1): Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| Weitere Sicherheitsinformationen | IMAP assessments - Benzenesulfonic acid, 4-hydroxy-, zinc salt (2:1): Human health tier I assessment |
| DOT-Kennzeichnung | Dangerous When Wet |
| Brandgefahren | Special Hazards of Combustion Products: Irritating oxides of sulfur may form in fires. (USCG, 1999) |
| Gesundheitsgefahren | Inhalation of dust may irritate nose and throat. Ingestion of large doses has emetic and astringent effectscan cause irritation or corrosion of the alimentary tract. Contact with eyes causes irritation. Contact with skin causes mild irritation. (USCG, 1999) |
| Gefahrenübersicht | A 3% solution, applied 8 times over 7 days, caused the cornea of a rabbit to become opaqueAlso a single application of a 3% solution caused corneal necrosis of an infantOral LD50 (rat) = 1800 mg/kg[HSDB] An eye and mild skin irritant[CAMEO] Skin contact causes mild irritation[CHRIS] Toxic by ingestion--corrosive to GI tract[EPA OHM/TADS] |
| Reaktive Gruppe | Phenols and Cresols |
| Special Reports | Zinc and Health. Current Bibliographies in Medicine 98-3. Public Services Division/National Library of Medicine. 3619 citations January, 1990-June, 1998. Available from: http://www.nlm.nih.gov/archive/20040831/pubs/cbm/zinc.html as of November 2, 1998.USEPAAmbient Water Quality Criteria Doc: Zinc (1980) EPA 400/5-80-079Ambient Water Quality Criteria Doc: Zinc (1987) EPA 400/5-87-003Arvidson, B. A Review of Axonal Transport of Metals. Toxicology 88: 1-14 (19994) Recent findings regarding axonal transport of metals, including zinc.For more Special Reports (Complete) data for ZINC PHENOLSULFONATE (6 total), please visit the HSDB record page. |
| Reactivity Profile | ZINC PHENOLSULFONATE behaves as a weak acid in solution. Therefore, it would react with bases in neutralization reactions that would generate heat. |
| Air and Water Reactions | Soluble in water. Turns pink on exposure to air. |
| Toxic Combustion Products | Irritating oxides of sulfur may form in fires. /Octahydrate/ |
| CERCLA-Meldepflichtmengen | Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b). |
| Brandbekämpfung | Excerpt from ERG Guide 138 [Substances - Water-Reactive (Emitting Flammable Gases)]: |
| Erste Hilfe | INHALATION: move to fresh air. |
| Lagerbedingungen | Storage temp: ambient |
| Freisetung ohne Brand | Excerpt from ERG Guide 138 [Substances - Water-Reactive (Emitting Flammable Gases)]: |
| Entsorgungsverfahren | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. |
| Isolation and Evacuation | Excerpt from ERG Guide 138 [Substances - Water-Reactive (Emitting Flammable Gases)]: |
| Minimum Risk Level | Intermediate Oral: 0.3 mg/kg/day (L134) Chronic Oral: 0.3 mg/kg/day (L134) |
| Protective Action Criteria (PAC) | 5.4 [mg/m3]59 [mg/m3]360 [mg/m3] |
| Personal Protective Equipment (PPE) | Dust maskgoggles or face shieldprotective gloves (USCG, 1999)/NIOSH certified respirator/protective gloves. /Octahydrate/ |
| Treatment | Zinc poisoning is treated symptomatically, often by administering fluids such as water or milk, or with gastric lavage. (L49) |
| Gesundheitliche Auswirkungen | Chronic exposure to zinc causes anemia, atazia, lethargy, and decreases the level of good cholesterol in the body. It is also believed to cause pancreatic and reproductive damage. (L49) |
| Expositionspfade | Oral (L49)inhalation (L49)dermal (L49) |
| Toxizitätsübersicht | Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.orgAnaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (L48, L49, A49) |
| Signs and Symptoms | Ingestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (L49) |
| Human Toxicity Excerpts | A single instance has been reported in which use of a 3% /zinc phenolsufonate/ soln in eye compresses resulted in complete necrosis of both corneas of an infant.Subjects using 30 mM zinc phenolsulfonate as a mouthwash retained 12% of the zinc. Salivary zinc concn was increased using mouthwashes containing 17-35 mM zinc as zinc sulfonate, zinc phenolsulfonate, or zinc citrate. At 17 mM, the effect lasted 3-4 hr. Zinc retained in the mouth gave visible fluorescence after rinsing with 8-hydroxyquinoline, and this was particularly evident on the tongue, cheek mucosa, and dental plaque. The concn of zinc in plaque was increased 13 19 fold 1 hr after using 31 or 18 mM zinc phenolsulfonate. The effect of zinc on the metabolic activity of plaque may reduce the growth rate of plaque bacteria and so decrease plaque growth. |
| Carcinogen Classification | No indication of carcinogenicity to humans (not listed by IARC). |
| Non-Human Toxicity Excerpts | EXPERIMENTAL APPLICATION OF THIS SOLN /3% ZINC PHENOLSULFONATE/ EIGHT TIMES TO EYE OF RABBIT CAUSED CORNEA TO BECOME COMPLETELY OPAQUE IN SEVEN DAYS. |
| Probable Routes of Human Exposure | Use of zinc phenolsulfonate in therapeutic applications will result in considerable human exposure. (SRC) |
| Antidote and Emergency Treatment | Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mg/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with sterile dressings after decontamination ... . /Sulfur and related compounds/Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Early intubation at the first sign of upper airway obstruction may be necessary. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W TKO /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . Treat seizures with diazepam (Valium) ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors for hypotension with a normal fluid volume. Watch for signs of fluid over load ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Sulfur and related compounds/ |
| Toxicity Data | LC (rat) > 208,000 mg/m3/1hLD50: 1800 mg/kg (Oral, Rat) (T14) LD50: 225 mg/kg (Intraperitoneal, Mouse) (T14) |
| Non-Human Toxicity Values | LD50 Oral Rat 1800 mg/kgLD50 Oral Mouse 3 g/kgLD50 ip Mouse 225 mg/kg |
| Clean Water Act Anforderungen | Designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance.Toxic pollutant designated pursuant to section 307(a)(1) of the Clean Water Act and is subject to effluent limitations. /Zinc and cmpds/For total recoverable zinc the criterion-to protect freshwater aquatic life ... is 47 ng/l as a 24 hr average ... at hardnesses of 50, 100, and 200 mg/l as CaCO3 the concentration of total recoverable zinc should not exceed 180, 320, 570 ug/l at any time. /Soluble zinc salts/For total recoverable zinc the criterion to protect saltwater aquatic life ... is 58 ug/l as a 24 hr average and the concentration should not exceed 170 ug/l at any time. /Soluble zinc salts/ |
| State Drinking Water Standards | (AZ) ARIZONA 5000 ug/l /Zinc/ |
| Landesrichtlinien für Trinkwasser | (MN) MINNESOTA 2000 ug/l /Zinc/ |
| Bundesrichtlinien für Trinkwasser | EPA 5000 ug/l /Zinc/EPA 2000 ug/l /Zinc, Lifetime health advisory/ |
| TSCA-Inventar-Status | TSCA listed |
| Gefahrstoffdaten | 127-82-2(Hazardous Substances Data) |
Anwendungen & Verwendung
Verwenden
Insecticide, medicine (antiseptic).