HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ebastine
EBASTIN · LAS-90 · EBASTEL · Ebasine · Estivan · EVASTEL · KESTINE · ebastina
Identifikatoren & physikalische Daten
| CAS No. | 90729-43-4 |
|---|---|
| Summenformel | C32H39NO2 |
| Durchschnittliche Molmasse | 469,7 g/mol |
| Monoisotopische Masse | 469,29807949 g/mol |
| SMILES | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 |
| InChIKey | MJJALKDDGIKVBE-UHFFFAOYSA-N |
| PubChem CID | 3191 |
| ChEMBL | CHEMBL305660 |
| ChEBI | CHEBI:31528 |
| EC No. | 635-609-6 |
| DTXSID | DTXSID6046472 |
Chemische & physikalische Eigenschaften
| XLogP | 7,2 |
|---|---|
| Polarare Oberfläche (TPSA) | 29,5 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 3 |
| Frei drehbare Bindungen | 10 |
| Schwere Atome | 35 |
| Formalladung | 0 |
| Komplexität | 594 |
| Arzneimittel | PharmaceuticalsPharmaceuticals -> Listed in ZINC15 |
| Human Drugs | Breast FeedingLactationAntihistaminesMilk, HumanNonsedating Antihistamines |
| Schmelzpunkt | 80-82°C |
| Siedepunkt | 596.3±50.0 °C(Predicted) |
| Dichte | 1.09±0.1 g/cm3(Predicted) |
| Lagerbedingungen | 2-8°C |
| Löslichkeit | Slightly soluble in chloroform, methanol. |
| pKa (Säurekonstante) | 8.19±0.10(Predicted) |
| Aggregatzustand | solid |
| Farbe | white |
| Merck | 14,3484 |
| InChIKey | MJJALKDDGIKVBE-UHFFFAOYSA-N |
| SMILES | C(C1=CC=C(C(C)(C)C)C=C1)(=O)CCCN1CCC(OC(C2=CC=CC=C2)C2=CC=CC=C2)CC1 |
| CAS Datenbank | 90729-43-4(CAS DataBase Reference) |
Sicherheit & Vorschriften
| GHS-Einstufung | H413 (97.6%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]P273, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 41 reports by companies from 2 notifications to the ECHA C&L Inventory. |
|---|---|
| Hazard Classes and Categories | Aquatic Chronic 4 (97.6%) |
| Drug Induced Liver Injury | Drug-Induced Liver Injury Severity and Toxicity (DILIst)EBASTINEDILI PositiveDOI:10.1016/j.drudis.2019.09.022 |
| Effects During Pregnancy and Lactation | ◉ Summary of Use during Lactation |
| Wassergefährdungsklasse (WGK) | 3 |
| Zollcode | 2933.39.9200 |
| RTECS-Nr. | EL8140000 |
| Lagerklasse | 11 - Combustible Solids |
Anwendungen & Verwendung
Beschreibung
Ebastine is a new once-daily histamine Hl-receptor antagonist with no sedative effects or autonomic impairment at therapeutic doses. It is reported to be effective in the treatment of hay fever, perennial rhinitis, and uticaria. Ebastine's antihistamine activity is attributed to its carboxylic acid metabolite carebastine.
Verwenden
Ebastine is a second-generation H1 receptor antagonist that is indicated mainly for allergic rhinitis and chronic idiopathic urticaria. It is available in 10 and 20 mg tablets and as fast-dissolving tablets, as well as in pediatric syrup. It has a recommended flexible daily dose of 10 or 20 mg, depending on disease severity.