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Haematoxylin
Homaeoxylin · hematoxyline · hydroxybrazilin · Hematoxylin powder · HEMATOXYLIN CERTIFIED · HEMATOXYLIN INDICATOR · C.I.75290 · nci-c55889
Identifikatoren & physikalische Daten
| CAS No. | 517-28-2 |
|---|---|
| Summenformel | C16H14O6 |
| Durchschnittliche Molmasse | 302,28 g/mol |
| Monoisotopische Masse | 302,07903816 g/mol |
| SMILES | Oc1cc2c(cc1O)[C@H]1c3ccc(O)c(O)c3OC[C@@]1(O)C2 |
| InChIKey | WZUVPPKBWHMQCE-CJNGLKHVSA-N |
| PubChem CID | 320930 |
| ChEMBL | CHEMBL1448387 |
| ChEBI | CHEBI:51684 |
| Lokaler Name | Haematoxylin |
Chemische & physikalische Eigenschaften
| XLogP | 1,2 |
|---|---|
| Polarare Oberfläche (TPSA) | 110 |
| H-Brücken-Donoren | 5 |
| H-Brücken-Akzeptoren | 6 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 22 |
| Formalladung | 0 |
| Komplexität | 444 |
| Endocrine Disruptors | Potential endocrine disrupting compound |
| Schmelzpunkt | 200 °C (dec.)(lit.) |
| Siedepunkt | 363.32°C (rough estimate) |
| Dichte | 1.2514 (rough estimate) |
| Dampfdruck | 0-0Pa at 20-25℃ |
| Brechungsindex | 1.4600 (estimate) |
| Lagerbedingungen | Keep in dark place,Inert atmosphere,Room temperature |
| Löslichkeit | Soluble in 95% ethanol(1 mg/mL).SOLUBLE IN HOT WATER |
| Aggregatzustand | Powder/Solid |
| pKa (Säurekonstante) | 6.7(at 25℃) |
| Farbe | Yellow to Brown |
| Merck | 14,4637 |
| BRN | 91399 |
| Stabilität | Stable, but may discolour on exposure to light. Incompatible with strong oxidizing agents. |
| Hauptanwendungen | Plasma displays, textiles, hair dyes, identifying fresh and stale rice, diag-nosing cancer progression, detecting nosing cancer progression, cervical disease, central nervous system malfunctions, detecting genes, breast cancer, collagen in a tissue sample, apoptosis, demyelinating diseases, antigens, treatment of age-related macular degeneration, burns, prostate cancer, diabetesand obesity, viral diseases, neoplasms, peripheral neural and vascular ailments, skin disorders, biotechnological applications, reference standard materials for cytology, histology andimmunohistochemistry |
| InChI | 1S/C16H14O6/c17-10-2-1-8-13-9-4-12(19)11(18)3-7(9)5-16(13,21)6-22-15(8)14(10)20/h1-4,13,17-21H,5-6H2/t13-,16+/m0/s1 |
| InChIKey | WZUVPPKBWHMQCE-UHFFFAOYSA-N |
| SMILES | Oc1cc2C[C@@]3(O)COc4c(O)c(O)ccc4[C@H]3c2cc1O |
| LogP (Verteilungskoeffizient) | 0.3 at 30℃ and pH6.9 |
| CAS Datenbank | 517-28-2 |
| EPA chemische Informationen | Hematoxylin (517-28-2) |
Sicherheit & Vorschriften
| Wassergefährdungsklasse (WGK) | 2 |
|---|---|
| TSCA-Inventar-Status | TSCA listed |
| Zollcode | 32030019 |
| RTECS-Nr. | MH7875000 |
| R-Sätze (R) | 22-36/37/38 |
| Gefahrensymbole | Xn,Xi |
| Sicherheitshinweise (S) | 26-36 |
| Lagerklasse | 11 - Combustible Solids |
| Gefahrstoffdaten | 517-28-2(Hazardous Substances Data) |
| Gefahrenklasse | Eye Irrit. 2 |
Anwendungen & Verwendung
Verwenden
Hematoxylin and eosin together make up Hematoxylin and eosin stain, one of the most commonly used stains in histology. Metal-haematein complexes are used to stain cell nuclei prior to examination under a microscope. Structures that stain with iron- or aluminum-haematein are often called basophilic, even though the mechanism of the staining is different from that of staining with basic dyes.