Grundinformationen
- Standard-SMILES
CCOC(=O)C1(c2ccccc2)CCNCC1- InChIKey
QKHMFBKXTNQCTM-UHFFFAOYSA-N- Summenformel
- C14H19NO2
- Durchschnittliche Molmasse
- 233,31 g/mol
- Monoisotopische Masse
- 233,14157885
Überblick
Pethidine-Intermediate-B, ethyl-4-phenylpiperidine-4-carboxylate is a DEA Schedule II controlled substance. Substances in the DEA Schedule II have a high potential for abuse which may lead to severe psychological or physical dependence. It is a Opiates substance.
Namen und Bezeichner
- Bevorzugter Name
- Normeperidine
- IUPAC
- ethyl 4-phenylpiperidine-4-carboxylate
- Lokaler Name
- Ethyl-4-phenylpiperidin-4-carboxylat
- Englischer Name
- NORMEPERIDINE
- Summenformel
- C14H19NO2
- Molmasse
- 233.31
Namen und Synonyme
Ethyl 4-phenylpiperidine-4-carboxylateNormeperidineNorpethidine77-17-8Nordolsin4-Piperidinecarboxylic acid, 4-phenyl-, ethyl esterJG096PMW2NIDS-NP-003DTXSID50227806NSC-23821PETHIDINE-INTERMEDIATE-B, ETHYL-4-PHENYLPIPERIDINE-4-CARBOXYLATERefChem:166645
Weitere Namen anzeigen
Pethidine Intermediate BNormeperidine solutionNorpethidine (Normeperidine)NORMEPERIDINE,100/MLINMETHANOL
DTXCID60150297201-008-9Ethyl 4-phenylisonipecotate4-Carbethoxy-4-phenylpiperidine4-Phenyl-4-carbethoxypiperidine4-(Ethoxycarbonyl)-4-phenylpiperidine4-Phenylpiperidine-4-carboxylic acid ethyl esterIsonipecotic acid, 4-phenyl-, ethyl ester
Datenbank-Bezeichner
- CAS
77-17-8- PubChem CID
- 32414
- DTXSID
DTXSID50227806- ChEMBL
CHEMBL1052- UNII
- JG096PMW2N
- EC Number
- 201-008-9
- Nikkaji
- J104.492C
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 2
- Polarare Oberfläche (TPSA)
- 38,3 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 3
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 17
- Formalladung
- 0
- Komplexität
- 253
Experimentelle und physikochemische Eigenschaften
DrugsDEA Schedule II Controlled Substance -> Opiates
Physikochemische Eigenschaften
- Schmelzpunkt
- 36 · 36-38 °C
- Siedepunkt
- 155 °C · 155 °C(Press: 3.5 Torr)
- Dichte
- 1.064 · 1.064±0.06 g/cm3(Predicted)
- Flammpunkt
- 11 °C · 11 °C
- storage temp.
- 2 · 2-8°C
- pka
- 9.58 · 9.58±0.10(Predicted)
Sicherheit und Regulatorisches
GHS-Klassifizierung
GHS Classification
Warning
H302 (97.5%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 40 reports by companies from 2 notifications to the ECHA C&L Inventory.
Gefahrenhinweise
Regulatory InformationDEA schedule II controlled substance
Other Safety InformationIMAP assessments - 4-Piperidinecarboxylic acid, 4-phenyl-, ethyl ester: Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 4 (97.5%)
Sicherheitsdaten
- wgk
- 1
- ridadr
- UN 1230 3/PG 2
- risk_code
- 11-23/24/25-39/23/24/25
- hazard_code
- F,T
- safety_code
- 7-16-36/37-45
Chemie und Industrie
Pharmakologische Informationen
Metabolism/MetabolitesNormeperidine is a known human metabolite of meperidine.
MeSH Pharmacological Classification
Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.
Cellular LocationsMembrane
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
Nachgelagerte Produkte
Zugehörige Reaktionen
27
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