6-((4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl)oxy)-14-ethyl-7,12,13-trihydroxy-4-((5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy)-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione
USP · ERYTHROMYCIN BASE · em · Erythro · ERYTHROMYCIN A · erytromycin · erythrocin · (-)-Erythromycin
Identifikatoren & physikalische Daten
| CAS No. | 114-07-8 |
|---|---|
| Summenformel | C37H67NO13 |
| Durchschnittliche Molmasse | 733,9 g/mol |
| Monoisotopische Masse | 733,4612412 g/mol |
| SMILES | CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)C(=O)C(C)C(O)C1(C)O |
| InChIKey | ULGZDMOVFRHVEP-UHFFFAOYSA-N |
| PubChem CID | 3255 |
| ChEMBL | CHEMBL1671887 |
| DTXSID | DTXSID90859206 |
Chemische & physikalische Eigenschaften
| XLogP | 2,7 |
|---|---|
| Polarare Oberfläche (TPSA) | 194 |
| H-Brücken-Donoren | 5 |
| H-Brücken-Akzeptoren | 14 |
| Frei drehbare Bindungen | 7 |
| Schwere Atome | 51 |
| Formalladung | 0 |
| Komplexität | 1.180 |
| Arzneimittel | Pharmaceuticals |
| Schmelzpunkt | 133 °C |
| Siedepunkt | 719.69°C (rough estimate) |
| Dichte | 1.1436 (rough estimate) |
| Brechungsindex | -74 ° (C=2, EtOH) |
| Lagerbedingungen | Inert atmosphere,Room Temperature |
| Löslichkeit | ethanol: solubleSoluble in water at 2mg/ml |
| Aggregatzustand | powder |
| pKa (Säurekonstante) | 8.8(at 25℃) |
| Farbe | white to faint yellow |
| Biologische Quelle | Streptomyces erythreus |
| Merck | 14,3681 |
| BRN | 8183758 |
| Hauptanwendungen | pharmaceutical (small molecule) |
| InChIKey | HIYRERIGRWIODP-PNFGZDISSA-N |
| EPA chemische Informationen | Erythromycin (114-07-8) |
Sicherheit & Vorschriften
| F | 3-4.3-10 |
|---|---|
| Wassergefährdungsklasse (WGK) | 2 |
| Zollcode | 29415000 |
| RTECS-Nr. | KF4375000 |
| R-Sätze (R) | 42/43-36/37/38 |
| Toxizität | LD50 oral in rat: 4600mg/kg |
| Gefahrensymbole | Xn,Xi |
| Sicherheitshinweise (S) | 45-37-24-36-26-24/25 |
| Gefahrenklasse | 3 |
| Lagerklasse | 11 - Combustible Solids |
| Gefahrstoffdaten | 114-07-8(Hazardous Substances Data) |
Anwendungen & Verwendung
Beschreibung
Erythromycin ethyl succinate is a mixed double ester pro-drug in which one carboxyl of succinic acid esterifies the C-2′ hydroxyl of erythromycin and the other ethanol. This pro-drug frequently is used in an oral suspension for pediatric use largely to mask the bitter taste of the drug. Film-coated tablets also are used to deal with this. Some cholestatic jaundice is associated with the use of EES.
Verwenden
Erythromycin A is a 14-membered macrocyclic lactone with broad spectrum antibiotic activity, isolated from Saccharopolyspora erythraea (formerly Streptomyces erythreus) in 1952. Erythromycin is one of only a handful of microbial metabolites to have profoundly shaped the treatment of bacterial disease in the last 50 years. Erythromycin has given rise to new generations of semi-synthetic derivatives with improved stability and potency. Our product has been HPLC-purified to remove contaminants and degradation products.