1,2,3,4-Tetrahydro-6-nitro-2,3-dioxobenzo(f)quinoxaline-7-sulfonamide
Grundinformationen
- CAS
118876-58-7- Standard-SMILES
NS(=O)(=O)c1cccc2c1c([N+](=O)[O-])cc1[nH]c(=O)c(=O)[nH]c12- InChIKey
UQNAFPHGVPVTAL-UHFFFAOYSA-N- Summenformel
- C12H8N4O6S
- Durchschnittliche Molmasse
- 336,28 g/mol
- Monoisotopische Masse
- 336,01645516
Überblick
2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline is a member of naphthalenes and a sulfonic acid derivative.
Namen und Bezeichner
- Bevorzugter Name
- 1,2,3,4-Tetrahydro-6-nitro-2,3-dioxobenzo(f)quinoxaline-7-sulfonamide
- IUPAC
- 6-nitro-2,3-dioxo-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide
- Englischer Name
- NBQX DISODIUM SALT
- Summenformel
- C12H8N4O6S
- Molmasse
- 336.28
Namen und Synonyme
nbqx118876-58-72,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxalineFG-92022,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline6-Nitro-7-sulfamoylbenzo(f)quinoxaline-2,3-dione8LZ6Q43V2S6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-DioneDTXSID601522561,2,3,4-tetrahydro-6-nitro-2,3-dioxobenzo[f]quinoxaline-7-sulfonamideBenzo(f)quinoxaline-7-sulfonamide, 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-6-nitro-2,3-dioxo-1H,2H,3H,4H-benzo[f]quinoxaline-7-sulfonamide
Weitere Namen anzeigen
NBQX DISODIUMNBQX NEWNBQX HYDRATENBQX (FG9202)FG 9202 DISODIUMDihydroxyquinoneNBQX DISODIUM SALTNBQX, 10 mM in DMSO
2,3-Dioxo-6-nitro-7-sulfamoylbenzo[f]quinoxaline6-nitro-2,3-dioxo-1H,2H,3H,4H-benzo(f)quinoxaline-7-sulfonamide1,2,3,4-Tetrahydro-6-nitro-2,3-dioxobenzo(f)quinoxaline-7-sulfonamideBenzo[f]quinoxaline-7-sulfonamide, 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-RefChem:442573DTXCID7074747FG 92026-nitro-2,3-dioxo-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 0,1
- Polarare Oberfläche (TPSA)
- 173 Ų
- H-Brücken-Donoren
- 3
- H-Brücken-Akzeptoren
- 7
- Frei drehbare Bindungen
- 1
- Schwere Atome
- 23
- Formalladung
- 0
- Komplexität
- 653
Experimentelle und physikochemische Eigenschaften
LogP0.36
Physikochemische Eigenschaften
- Schmelzpunkt
- 361 °C · 361°C
- Dichte
- 1.6027 · 1.6027 (rough estimate)
- Brechungsindex
- 1.6 · 1.6000 (estimate)
- storage temp.
- 2 · Inert atmosphere,2-8°C
- Löslichkeit
- 0.25 mg/mL · methanol: 0.25 mg/mL
- Aggregatzustand
- solid
- pka
- 7.55 · 7.55±0.20(Predicted)
- Farbe
- yellow
- Wasserlöslichkeit
- 2 O: · H2O: >10mg/mL
- Stabilität
- -20 °C · Freezer at -20°C
- InChI
- InChI=1S/C12H8N4O6S/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22)
- InChIKey
- UQNAFPHGVPVTAL-UHFFFAOYSA-N
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazard Classes and CategoriesSkin Irrit. 2 (100%)
Sicherheitsdaten
- wgk
- 3
- risk_code
- 36/37/38
- hazard_code
- Xi
- safety_code
- 26-36
- Speicherklasse
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2Skin Irrit. 2STOT SE 3
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Drugs used to prevent SEIZURES or reduce their severity.
Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.
Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists.
Anwendungen
VerwendenNBQX disodium salt hydrate has been used:in N-methyl-D-aspartate receptor (NMDAR) kinetic studiesas an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist for the electrophysiological studies cultured neuronsin the extracellular solution for current/voltage (I/V) relationship and rectification index experiments in excitatory postsynaptic currents (EPSCs) mediated by NMDA receptors (EPSCNMDAR)
Anbieter81 Anbieter
陕西科贝莱药物研发有限公司13119135307 13119135307 · [email protected]
湖南韵邦生物科技股份有限公司0731-88532326 13319508186 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
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