| GHS-Einstufung | WarningH302 (97.5%): Harmful if swallowed [Warning Acute toxicity, oral]P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 40 reports by companies from 2 notifications to the ECHA C&L Inventory. |
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| Regulatorische Informationen | DEA schedule IV controlled substanceCyclohexanol, 1-ethynyl-, carbamate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right. |
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| FDA-Anforderungen | Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended21 U.S.C. 321-392).Schedules of controlled substances are established by section 202 of the Controlled Substances Act (21 U.S.C. 812). Schedule IV includes ethinamate, DEA Code #2545Drug class: Depressant.Drugsstatement of required warning. The label of any drug listed as a "controlled substance" in schedule II, III, or IV of the Federal Controlled Substances Act shall, when dispensed to or for a patient, contain the following warning: "Caution: Federal law prohibits the transfer of this drug to any person other than the patient for whom it was prescribed." This statement is not required to appear on the label of a controlled substance for use in clinical investigations which are "blind".... Currently marketed prescriptive drug ... oral ethinamate.Controlled substance in the USA - Schedule IV. |
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| Hazard Classes and Categories | Acute Tox. 4 (97.5%) |
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| Lagerbedingungen | Store below 40 °C (104 °F), preferably between 15 and 30 °C. ... Store in a tight container. |
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| Wechselwirkungen | 2,4-DICHLORO-(6-PHENYLPHENOXY)ETHYLAMINE IS PARTICULARLY EFFECTIVE /MICROSOMAL DRUG METABOLISM/ INHIBITOR, PROLONGING HEXOBARBITAL & ETHINAMATE SLEEPING TIMES IN MICE & DOGS.If ethinamate is ingested concurrently with alcohol or other central nervous system depressants, the potential hazards of both these agents are increased. |
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| Gesundheitliche Auswirkungen | They cause slurred speech, disorientation and "drunken" behavior. They are physically and psychologically addictive. |
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| Expositionspfade | Rapidly absorbed following oral administration. |
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| Toxizitätsübersicht | The mechanism of action is not known. However, studies have shown that ethinamate inhibits carbonic anhydrases I and II (J Biol Chem. 1992 Dec 15267(35):25044-50). This inhibition by ethinamate is not sufficiently strong, however, to implicate carbonic anhydrases I and II in the mechanism of action. |
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| Signs and Symptoms | Symptoms of overdose include shortness of breath or slow or troubled breathing, slow heartbeat, severe weakness, chronic confusion, slurred speech, and staggering. |
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| Human Toxicity Excerpts | SIDE EFFECTS ... INCL NAUSEA, OCCASIONAL VOMITING, & INFREQUENTLY RASH. IDIOSYNCRATIC EXCITEMENT MAY BE NOTED. FEVER & THROMBOCYTOPENIA OCCUR RARELY.IN ONE PATIENT 16 G PRODUCED COMA, BUT RECOVERY WAS APPARENTLY COMPLETE 6 HR AFTER INGESTION. IN @ LEAST TWO OTHER ADULTS, HOWEVER, 15 G PRODUCED PROFOUND COMA, & ONE VICTIM EXPIRED FROM SUPERVENING PULMONARY EDEMA.LONG TERM USE OF LARGER THAN RECOMMENDED DOSES MAY LEAD TO PSYCHIC & PHYSICAL DEPENDENCE.LETHAL DOSE IS UNKNOWNDEATH HAS RESULTED FROM INGESTION OF 15 G.For more Human Toxicity Excerpts (Complete) data for ETHINAMATE (8 total), please visit the HSDB record page. |
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| Carcinogen Classification | No indication of carcinogenicity to humans (not listed by IARC). |
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| TSCA-Inventar-Status | TSCA listed |
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| RTECS-Nr. | GV9275000 |
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| R-Sätze (R) | 23/24/25-22 |
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| Gefahrensymbole | T,Xn |
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| Sicherheitshinweise (S) | 22-36/37/39-45 |
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| Gefahrstoffdaten | 126-52-3(Hazardous Substances Data) |
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