Etilefrin

Ethylephrine hydrochloride · S 40032 · Etilefrin · S 40032-7 · Aids001656 · Etilephrine · Aids-001656 · dl-Etilefrin

Identifikatoren & physikalische Daten

CAS No.	10128-36-6
Summenformel	C10H15NO2
Durchschnittliche Molmasse	181,23 g/mol
Monoisotopische Masse	181,11027872 g/mol
SMILES	CCNCC(O)c1cccc(O)c1
InChIKey	SQVIAVUSQAWMKL-UHFFFAOYSA-N
PubChem CID	3306
ChEMBL	CHEMBL86882
ChEBI	CHEBI:91518
EC No.	211-910-4
DTXSID	DTXSID1023029
Lokaler Name	Etilefrin

Chemische & physikalische Eigenschaften

XLogP	0,1
Polarare Oberfläche (TPSA)	52,5
H-Brücken-Donoren	3
H-Brücken-Akzeptoren	3
Frei drehbare Bindungen	4
Schwere Atome	13
Formalladung	0
Komplexität	141
Arzneimittel	Pharmaceuticals -> Sympathomimetics
Löslichkeit	18.9 [ug/mL] (The mean of the results at pH 7.4)
Human Drugs	Pharmaceuticals
Schmelzpunkt	208-209147-148°
Siedepunkt	314.35°C (rough estimate)
Dichte	1.0918 (rough estimate)
Brechungsindex	1.5464 (estimate)
pKa (Säurekonstante)	9.81±0.10(Predicted)
Aggregatzustand	Solid
Farbe	Off-white to pink
LogP (Verteilungskoeffizient)	3.2 at 25℃ and pH5.5

Sicherheit & Vorschriften

GHS-Einstufung	DangerH301 (50%): Toxic if swallowed [Danger Acute toxicity, oral]P261, P264, P264+P265, P270, P271, P273, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Regulatorische Informationen	REACH registered substance: Etilefrine (EC: 211-910-4)
Hazard Classes and Categories	Acute Tox. 3 (50%)
Alarmwort	Achtung
Gefahrenhinweise	Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H301

Anwendungen & Verwendung

Verwenden

ETILEFRINE-D5 is a sympathomimetic drug that increases the pulse rate, cardiac output, stroke volume, central venous pressure and mean arterial pressure of healthy individuals. Etilefrin has both beta 1 and alpha adrenergic effects on humans and is mainly used for the treatment of patients with orthostatic hypotension.