HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
5'-Adenylic acid, anhydride with imidodiphosphoric acid (1:1)
AMP-PNP · Phosphoaminophosphonic acid-adenylate ester · AMP-P(NH)P · β,γ-ImidoATP · β,γ-Imido-ATP · 93% (HPLC), powder · Adenyl imidodiphosphate · Adenylyl Imidodiphosphate
Identifikatoren & physikalische Daten
| CAS No. | 114661-04-0 |
|---|---|
| Summenformel | C10H17N6O12P3 |
| Durchschnittliche Molmasse | 506,2 g/mol |
| Monoisotopische Masse | 506,01173099 g/mol |
| SMILES | Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)NP(=O)(O)O)[C@@H](O)[C@H]1O |
| InChIKey | PVKSNHVPLWYQGJ-KQYNXXCUSA-N |
| PubChem CID | 33113 |
| ChEMBL | CHEMBL1230989 |
| ChEBI | CHEBI:47785 |
| DTXSID | DTXSID90180289 |
Chemische & physikalische Eigenschaften
| XLogP | -6 |
|---|---|
| Polarare Oberfläche (TPSA) | 282 |
| H-Brücken-Donoren | 8 |
| H-Brücken-Akzeptoren | 17 |
| Frei drehbare Bindungen | 8 |
| Schwere Atome | 31 |
| Formalladung | 0 |
| Komplexität | 801 |
| Siedepunkt | 965.5±75.0 °C(Predicted) |
| Dichte | 2.65±0.1 g/cm3(Predicted) |
| Lagerbedingungen | -20°C |
| Löslichkeit | H2O: soluble50mg/mLH2O: 50mg/mL |
| Aggregatzustand | powder |
| pKa (Säurekonstante) | 1.16±0.50(Predicted) |
| Farbe | white |
| Biologische Quelle | natural (organic) |
| BRN | 6047109 |
| InChIKey | PVKSNHVPLWYQGJ-KQYNXXCUSA-N |
| SMILES | [Li+].[Li+].[Li+].[Li+].[H]O[H].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)NP([O-])([O-])=O)[C@@H](O)[C@H]3O |
Sicherheit & Vorschriften
| Wassergefährdungsklasse (WGK) | 3 |
|---|---|
| Sicherheitshinweise (S) | 22-24/25 |
| Lagerklasse | 11 - Combustible Solids |
Anwendungen & Verwendung
Verwenden
AMP-PNP is a competitive inhibitor of most ATP-dependent systems. A good substrate for enzymes hydrolyzing between the α- and β-phosphorus atom, yet is resistant to enzymes cleaving between the β- and γ-phosphorus atom. Substrate of snake venom phosphodiesterase and adenylate cyclase. AMP-PNP has been used for two-motor fluorescence assay.