HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HCID 333436Erstellt: 27. Oktober 2026
N-(tert-butoxycarbonyl)-N-methylleucine
BOC-N-ME-LEU-OH · N-(tert-butoxycarbonyl)-N-methyl-L-leucine · Tyr(Me) · BOC-MELEU-OH · BOC-LEU(ME)-OH · BOC-L-MELEU-OH · BOC-ALA(TBU)-OH · Boc-N-Me-Leu-0H
https://huagongshe.com/de/chemical/333436
Identifikatoren & physikalische Daten
| CAS No. | 53363-89-6 |
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| Summenformel | C12H23NO4 |
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| Durchschnittliche Molmasse | 245,32 g/mol |
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| Monoisotopische Masse | 245,16270821 g/mol |
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| SMILES | CC(C)CC(C(=O)O)N(C)C(=O)OC(C)(C)C |
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| InChIKey | YXJFAOXATCRIKU-UHFFFAOYSA-N |
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| PubChem CID | 333436 |
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Chemische & physikalische Eigenschaften
| XLogP | 2,4 |
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| Polarare Oberfläche (TPSA) | 66,8 |
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| H-Brücken-Donoren | 1 |
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| H-Brücken-Akzeptoren | 4 |
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| Frei drehbare Bindungen | 6 |
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| Schwere Atome | 17 |
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| Formalladung | 0 |
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| Komplexität | 281 |
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| Schmelzpunkt | 55-60 °C |
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| Siedepunkt | 338.2±21.0 °C(Predicted) |
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| Dichte | 1.053±0.06 g/cm3(Predicted) |
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| Lagerbedingungen | Sealed in dry,2-8°C |
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| pKa (Säurekonstante) | 4.04±0.21(Predicted) |
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| Aggregatzustand | Solid |
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| Farbe | White to off-white |
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| BRN | 2373250 |
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| Hauptanwendungen | peptide synthesis |
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| InChI | InChI=1S/C12H23NO4/c1-8(2)7-9(10(14)15)13(6)11(16)17-12(3,4)5/h8-9H,7H2,1-6H3,(H,14,15)/t9-/m0/s1 |
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| InChIKey | YXJFAOXATCRIKU-VIFPVBQESA-N |
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| SMILES | C(O)(=O)[C@H](CC(C)C)N(C(OC(C)(C)C)=O)C |
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| CAS Datenbank | 53363-89-6(CAS DataBase Reference) |
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Sicherheit & Vorschriften
| Wassergefährdungsklasse (WGK) | 3 |
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| Zollcode | 2924 19 00 |
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| Gefahrenklasse | IRRITANT |
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| Lagerklasse | 11 - Combustible Solids |
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Anwendungen & Verwendung
Beschreibung
Boc-N-methyl-L-leucine is the BOC (tert-butyloxycarbonyl) protected N-methylated leucine. The N-methylated amino acid is quite useful in the peptide synthesis, giving a lot of improved properties to peptide. Studies have shown that peptide containing N-methylated amino acids obtain increased proteolytic stability, increased membrane permeability, and altered conformation. The effects of N-methylated amino acids are quite important in the development of therapeutic peptide compound as well as in the assay of biological activity of some modified peptides. BOC group can be easily removed by treatment with strong acids such as trifluoroacetic acid.
