HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Fludiazepam
id540 · ID-540 · Erispan · Ro-5-3438 · FLUDIAZEPAM · Fludiazepan · Fludiazepam USP/EP/BP · Fludiazepam, 1mg/ml in Methanol
Identifikatoren & physikalische Daten
| CAS No. | 3900-31-0 |
|---|---|
| Summenformel | C16H12ClFN2O |
| Durchschnittliche Molmasse | 302,73 g/mol |
| Monoisotopische Masse | 302,0622189 g/mol |
| SMILES | CN1C(=O)CN=C(c2ccccc2F)c2cc(Cl)ccc21 |
| InChIKey | ROYOYTLGDLIGBX-UHFFFAOYSA-N |
| PubChem CID | 3369 |
| ChEMBL | CHEMBL13291 |
| ChEBI | CHEBI:31618 |
| DTXSID | DTXSID00192277 |
Chemische & physikalische Eigenschaften
| XLogP | 2,8 |
|---|---|
| Polarare Oberfläche (TPSA) | 32,7 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 3 |
| Frei drehbare Bindungen | 1 |
| Schwere Atome | 21 |
| Formalladung | 0 |
| Komplexität | 442 |
| Arzneimittel | DEA NFLIS-Drug Category -> BenzodiazepinesDEA Schedule IV Controlled Substance -> DepressantsPharmaceuticals -> Listed in ZINC15Pharmaceuticals -> Synthetic Cannabinoids or Psychoactive CompoundsPharmaceuticals -> Nervous system -> Anxiolytics |
| LogP (Verteilungskoeffizient) | 2.75 |
| Löslichkeit | 1.44e-02 g/LDMF: 25 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 15 mg/mlEthanol: 1 mg/ml |
| Human Drugs | Pharmaceuticals |
| Schmelzpunkt | 218.5-219295 - 297 °C88-92°mp 69-72° (Sternbach) |
| Physical Description | Solid |
| Siedepunkt | 498.1±45.0 °C(Predicted) |
| Dichte | 1.3159 (estimate) |
| Aggregatzustand | A crystalline solid |
| pKa (Säurekonstante) | pKa 2.29±0.009(H2O) (Uncertain) |
| NIST chemische Informationen | Fludiazepam(3900-31-0) |
Sicherheit & Vorschriften
| Regulatorische Informationen | DEA schedule IV controlled substance |
|---|---|
| Treatment | General supportive measures should be employed, along with intravenous fluids, and an adequate airway maintained. Hypotension may be combated by the use of norepinephrine or metaraminol. Dialysis is of limited value. Flumazenil (Anexate) is a competitive benzodiazepine receptor antagonist that can be used as an antidote for benzodiazepine overdose. In particular, flumazenil is very effective at reversing the CNS depression associated with benzodiazepines but is less effective at reversing respiratory depression. Its use, however, is controversial as it has numerous contraindications. It is contraindicated in patients who are on long-term benzodiazepines, those who have ingested a substance that lowers the seizure threshold, or in patients who have tachycardia or a history of seizures. As a general rule, medical observation and supportive care are the mainstay of treatment of benzodiazepine overdose. Although benzodiazepines are absorbed by activated charcoal, gastric decontamination with activated charcoal is not beneficial in pure benzodiazepine overdose as the risk of adverse effects often outweigh any potential benefit from the procedure. It is recommended only if benzodiazepines have been taken in combination with other drugs that may benefit from decontamination. Gastric lavage (stomach pumping) or whole bowel irrigation are also not recommended. |
| Toxizitätsübersicht | Fludiazepam has similar action to diazepam, but binds with four times more affinity to benzodiazepine receptors than diazepam. |
| Signs and Symptoms | Symptoms of overdose include drowsiness, weakness, nausea, dizziness, abdominal pain, cerebral oedema and renal tubular necrosis, hyperglycaemia and hypoglycaemia, liver damage, encephalopathy, coma and death. |
| Carcinogen Classification | No indication of carcinogenicity to humans (not listed by IARC). |
| Toxizität | LD50 in mice (mg/kg): 910 orally360 i.p.1150 s.c. (Asami) |
Anwendungen & Verwendung
Beschreibung
Fludiazepam (Item No. 22424) is an analytical reference standard categorized as a benzodiazepine. Fludiazepam is regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications.
Verwenden
Fludiazepam is a drug which is a benzodiazepine derivative. Fludiazepam possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.