HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
PENITREM A
PENITREM A · TREMORTIN A · JDUWHZOLEDOQSR-JKPSMKLGSA-N · Penitrem A Nsc354845 · Penitrem A, blocker of KCa1.1 · PENITREM A, PENICILLIUM PAXILLI · Penitrem A from Penicillium paxilli · penitrem A from penicillium palitans
Identifikatoren & physikalische Daten
| CAS No. | 12627-35-9 |
|---|---|
| Summenformel | C37H44ClNO6 |
| Durchschnittliche Molmasse | 634,2 g/mol |
| SMILES | C=C(C)[C@H]1O[C@H]2CC[C@@]3(C)[C@@](O)(CC[C@H]4[C@@H]5OC(C)(C)[C@H]6C[C@@H]7C(=C)Cc8c(Cl)cc9[nH]c(c5c9c8C76O)[C@@]43C)[C@@]23O[C@H]3[C@H]1O |
| PubChem CID | 337313 |
Chemische & physikalische Eigenschaften
| Schmelzpunkt | 238°C |
|---|---|
| Dichte | 1.0241 (rough estimate) |
| Brechungsindex | 1.6000 (estimate) |
| Lagerbedingungen | 2-8°C |
| Löslichkeit | Soluble in DMSO (up to 6 mg/ml) |
| Aggregatzustand | White solid. |
| pKa (Säurekonstante) | 13.22±0.70(Predicted) |
| Farbe | Amorphous solid |
| Stabilität | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| InChIKey | JDUWHZOLEDOQSR-JKPSMKLGSA-N |
Sicherheit & Vorschriften
| Wassergefährdungsklasse (WGK) | 3 |
|---|---|
| UN-Transportnummer | UN 2811 6.1/PG 2 |
| Zollcode | 29349990 |
| RTECS-Nr. | RY7535000 |
| R-Sätze (R) | 26/27/28 |
| Toxizität | LD50 orl-mus: 10 mg/kg 41KEAL -,108,78 |
| Gefahrensymbole | T+,T |
| Sicherheitshinweise (S) | 36/37/39-45 |
| Gefahrenklasse | 6.1(a)Acute Tox. 2 Oral |
| Verpackungsgruppe | II |
| Lagerklasse | 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials |
Anwendungen & Verwendung
Occurrence
A series of closely related metabolites of Penicillium crustosum has recently been isolated and the components separated chromatographically. Penitrem A forms colourless crystals from EtOH.
Verwenden
Penitrem A is a tremorgenic mycotoxin isolated from Penicillium species. Penitrem A is a selective blocker of high-conductance Ca2+-activated potassium channels.