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Fluphenazin-O-decanoat

Fluphenazine Decanoate

HCID 3388
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Grundinformationen

CAS
5002-47-1
Standard-SMILES
CCCCCCCCCC(=O)OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1
InChIKey
VIQCGTZFEYDQMR-UHFFFAOYSA-N
Summenformel
C32H44F3N3O2S
Durchschnittliche Molmasse
591,8 g/mol
Monoisotopische Masse
591,31063331

Überblick

Fluphenazine decanoate is the prodrug of fluphenazine, an antipsychotic drug used for the symptomatic management of psychosis in patients with schizophrenia. It has a role as a phenothiazine antipsychotic drug, a dopaminergic antagonist and a prodrug. It is an organofluorine compound, a member of phenothiazines, a N-alkylpiperazine and a decanoate ester. It is functionally related to a fluphenazine.

Namen und Bezeichner

Bevorzugter Name
Fluphenazine Decanoate
IUPAC
2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl decanoate
Lokaler Name
Fluphenazin-O-decanoat
Englischer Name
Fluphenazine decanoate
Summenformel
C32H44F3N3O2S
Molmasse
591.77

Namen und Synonyme

Fluphenazine decanoate5002-47-1ModecateLyogenModiten depotDapotum DFluphenazine depotProlixin decanoateFlufenazine decanoateFluorophenazine decanoateFluphenaline decanoateDEPOT
Weitere Namen anzeigen
ecanoatedapotumdsq10,733moditendepotzinyl)ethylesterprolixindecanoatefluphenazinedepotflufenazinedecanoate
2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl decanoateNSC-169510FMU62K1L3CFluphenazini decanoasDTXSID7023069QD-10733SQ-10733NSC169510

Datenbank-Bezeichner

CAS
5002-47-1
PubChem CID
3388
DTXSID
DTXSID7023069
ChEMBL
CHEMBL1200854
ChEBI
CHEBI:5124
UNII
FMU62K1L3C
EC Number
225-672-4
Nikkaji
J13.702B

Eigenschaften

Berechnete Struktureigenschaften

XLogP
9
Polarare Oberfläche (TPSA)
61,3 Ų
H-Brücken-Donoren
0
H-Brücken-Akzeptoren
9
Frei drehbare Bindungen
16
Schwere Atome
41
Formalladung
0
Komplexität
765

Experimentelle und physikochemische Eigenschaften

Human Drugs · 2 Einträge

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Physikochemische Eigenschaften

Schmelzpunkt
30 · 30-32°
Siedepunkt
658.1 · 658.1±55.0 °C(Predicted)
Dichte
1.149 · 1.149±0.06 g/cm3(Predicted)
storage temp.
-20 °C · Store at -20°C
Löslichkeit
Practically insoluble in water, very soluble in ethanol and in methylene chloride, freely soluble in methanol.
Aggregatzustand
Oil
pka
7.32 · 7.32±0.10(Predicted)
Farbe
Light yellow to yellow
Major Application
pharmaceutical (small molecule)
InChIKey
VIQCGTZFEYDQMR-UHFFFAOYSA-N
SMILES
FC(F)(F)c1cc2c(cc1)Sc3c(cccc3)N2CCCN4CCN(CC4)CCOC(=O)CCCCCCCCC
CAS Datenbank
5002 · 5002-47-1

Sicherheit und Regulatorisches

Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.

GHS-Klassifizierung

GHS Classification · 4 Einträge

Danger

H300 (40%): Fatal if swallowed [Danger Acute toxicity, oral]

P203, P233, P260, P261, P264, P270, P271, P272, P280, P284, P301+P316, P301+P317, P302+P352, P304+P340, P317, P318, P321, P330, P332+P317, P333+P317, P342+P316, P362+P364, P403, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 30 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Hazard Classes and CategoriesAcute Tox. 2 (40%)

Sicherheitsdaten

wgk
WGK 3
ridadr
3249
RTECS-Nr.
HE0525000
hazard_class
6.1(a)
packing_group
II
Speicherklasse
6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials
Hazard Classifications
Acute Tox. 2 OralRepr. 2

Chemie und Industrie

Pharmakologische Informationen

FDA Pharmacological Classification · 2 Einträge

FLUPHENAZINE DECANOATE

Phenothiazines [CS]; Phenothiazine [EPC]

MeSH Pharmacological Classification · 2 Einträge

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.

Anwendungen

VerwendenFluphenazine Decanoate is used in psychotropic drug treatments like those relating to schizophrenia. Antipsychotic.

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