HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Flutazolam
MS-4104 · MS 4101 · Coreminal · Ro 7-6102 · Flutazolam · 10-Chloro-11b-(o-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one · 10-Chloro-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one · Oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one, 10-chloro-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)-
Identifikatoren & physikalische Daten
| CAS No. | 27060-91-9 |
|---|---|
| Summenformel | C19H18ClFN2O3 |
| Durchschnittliche Molmasse | 376,8 g/mol |
| Monoisotopische Masse | 376,0989983 g/mol |
| SMILES | O=C1CN2CCOC2(c2ccccc2F)c2cc(Cl)ccc2N1CCO |
| InChIKey | WMFSSTNVXWNLKI-UHFFFAOYSA-N |
| PubChem CID | 3398 |
| ChEMBL | CHEMBL1697836 |
| ChEBI | CHEBI:31628 |
| DTXSID | DTXSID6023072 |
Chemische & physikalische Eigenschaften
| XLogP | 2,2 |
|---|---|
| Polarare Oberfläche (TPSA) | 53 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 5 |
| Frei drehbare Bindungen | 3 |
| Schwere Atome | 26 |
| Formalladung | 0 |
| Komplexität | 539 |
| Arzneimittel | Pharmaceuticals -> Nervous system -> Anxiolytics |
| Schmelzpunkt | 142-147° |
| Siedepunkt | 601.9±55.0 °C(Predicted) |
| Dichte | 1.2970 (estimate) |
| Löslichkeit | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| Aggregatzustand | Solid |
| pKa (Säurekonstante) | 5.40(at 25℃) |
| Farbe | White to Pale Yellow |
Anwendungen & Verwendung
Beschreibung
Flutazolam is a benzodiazepine anxiolytic closely related to mexazolam. It is useful in the treatment of anxiety, stress and depression in hypersensitive colon syndrome, chronic gastritis, and gastric and duodenal ulcers.