9-Fluorenylmethyl chloroformate
Daten werden ergänzt – lade die Seite später neu, um den aktuellen Stand zu sehen
Grundinformationen
- CAS
28920-43-6- Standard-SMILES
O=C(Cl)OCC1c2ccccc2-c2ccccc21- InChIKey
IRXSLJNXXZKURP-UHFFFAOYSA-N- Summenformel
- C15H11ClO2
- Durchschnittliche Molmasse
- 258,7 g/mol
- Monoisotopische Masse
- 258,04475727
Überblick
used for tagging silica-based derivatization reagents in HPLC
Namen und Bezeichner
- Bevorzugter Name
- 9-Fluorenylmethyl chloroformate
- IUPAC
- 9H-fluoren-9-ylmethyl carbonochloridate
- Englischer Name
- 9-Fluorenylmethyl chloroformate
- Summenformel
- C15H11ClO2
- Molmasse
- 258.7
Namen und Synonyme
28920-43-69-Fluorenylmethyl chloroformate9-Fluorenylmethoxycarbonyl chloride1-(9-Fluorenyl)methyl chloroformateFluoren-9-ylmethyl chloroformate9PLB0BTT90FORMIC ACID, CHLORO-, FLUOREN-9-YLMETHYL ESTERDTXSID10183116RefChem:746059-FLMCDTXCID20105607249-313-6
Weitere Namen anzeigen
FoMc-ClFMOC-Cfmoc-ci9-FluorenylmethylFMOC-C1Fluorenylmethyloxycarbonyl chloride
Fmoc-ClFmoc-chloride(9h-fluoren-9-yl)methyl carbonochloridateFmoc chlorideCarbonochloridic acid, 9H-fluoren-9-ylmethyl ester9H-Fluoren-9-ylmethyl chloroformate9H-fluoren-9-ylmethyl carbonochloridate(9H-Fluoren-9-ylmethoxy)carbonyl Chloride
Datenbank-Bezeichner
- CAS
28920-43-6- PubChem CID
- 34367
- DTXSID
DTXSID10183116- UNII
- 9PLB0BTT90
- EC Number
- 249-313-6
- Nikkaji
- J311E
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- XLogP
- 4,3
- Polarare Oberfläche (TPSA)
- 26,3 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 2
- Frei drehbare Bindungen
- 3
- Schwere Atome
- 18
- Formalladung
- 0
- Komplexität
- 296
Physikochemische Eigenschaften
- Schmelzpunkt
- 62 · 62-64 °C(lit.)
- Siedepunkt
- 365.79 °C · 365.79°C (rough estimate)
- Dichte
- 1.178 · 1.1780 (rough estimate)
- Brechungsindex
- 1.533 · 1.5330 (estimate)
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- 0.1 g/mL, · dioxane: 0.1 g/mL, clear, colorless
- Aggregatzustand
- Crystalline Powder
- Farbe
- White to very pale yellow
- BRN
- 2279177 · 2279177
- Stabilität
- Hygroscopic, Moisture Sensitive
- InChI
- InChI=1S/C15H11ClO2/c16-15(17)18-9-14-12-7-3-1-5-10(12)11-6-2-4-8-13(11)14/h1-8,14H,9H2
- InChIKey
- IRXSLJNXXZKURP-UHFFFAOYSA-N
- SMILES
- C(Cl)(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
- LogP
- 3.45 · 3.45
- CAS Datenbank
- 28920 · 28920-43-6(CAS DataBase Reference)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H302 (17.5%): Harmful if swallowed [Warning Acute toxicity, oral]
P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P363, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 80 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory Information
Chemical: Carbonochloridic acid, 9H-fluoren-9-ylmethyl ester
Status: Active Update: 29-03-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/28092
(9-Fluorenylmethyl) chloroformate: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationEvaluation - Chemicals that are unlikely to require further regulation to manage risks to human health
Hazard Classes and CategoriesAcute Tox. 4 (17.5%)
Sicherheitsdaten
- F
- 10-21
- wgk
- 3
- tsca
- No
- ridadr
- UN 3261 8/PG 2
- hs_code
- 29159020
- RTECS-Nr.
- LQ6250000
- risk_code
- 34-20/21/22
- hazard_code
- C,T
- safety_code
- 26-36/37/39-45-27
- hazard_class
- 6.1
- packing_group
- II
- Speicherklasse
- 8A - Combustible corrosive hazardous materials
- Hazard Classifications
- Eye Dam. 1Skin Corr. 1B
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
Anwendungen
Beschreibung9-Fluorenylmethyl chloroformate (Fmoc-C1) is a significant biochemical reagent introduced by Carpino. It has been widely utilized as a reagent for the introduction of the 9-fluorenylmethoxycarbonyl (Fmoc moiety) in both peptide and nucleotide synthesis, as well as serving as a coupling agent in peptide synthesis[1]. Furthermore, Fmoc-C1 can function as a versatile fluorescent labeling reagent for primary and secondary amines[2].
Verwenden9-Fluorenylmethyl chloroformate is an N-Protecting agent for peptides research and was used for the pre-column derivatization of the biogenic amines (BAs) cadaverine (Cad), histamine (Him), octopami ne (Ocp), phenylethylamine (Pea), putrescine (Put), spermidine (Spd), spermine (Spm), tyramine (Tym).
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
Nachgelagerte Produkte
Zugehörige Reaktionen
332
Notizen zur Verbindung
Wird geladen…