9-Fluorenylmethyl chloroformate

HCID 34367CAS 28920-43-6

Grundinformationen

Standard-SMILES
O=C(Cl)OCC1c2ccccc2-c2ccccc21
InChIKey
IRXSLJNXXZKURP-UHFFFAOYSA-N
Summenformel
C15H11ClO2
Durchschnittliche Molmasse
258,7 g/mol
Monoisotopische Masse
258,04475727

Überblick

used for tagging silica-based derivatization reagents in HPLC

Namen und Bezeichner

Bevorzugter Name
9-Fluorenylmethyl chloroformate
IUPAC
9H-fluoren-9-ylmethyl carbonochloridate
Englischer Name
9-Fluorenylmethyl chloroformate
Summenformel
C15H11ClO2
Molmasse
258.7

Namen und Synonyme

28920-43-69-Fluorenylmethyl chloroformate9-Fluorenylmethoxycarbonyl chloride1-(9-Fluorenyl)methyl chloroformateFluoren-9-ylmethyl chloroformate9PLB0BTT90FORMIC ACID, CHLORO-, FLUOREN-9-YLMETHYL ESTERDTXSID10183116RefChem:746059-FLMCDTXCID20105607249-313-6
Weitere Namen anzeigen
FoMc-ClFMOC-Cfmoc-ci9-FluorenylmethylFMOC-C1Fluorenylmethyloxycarbonyl chloride
Fmoc-ClFmoc-chloride(9h-fluoren-9-yl)methyl carbonochloridateFmoc chlorideCarbonochloridic acid, 9H-fluoren-9-ylmethyl ester9H-Fluoren-9-ylmethyl chloroformate9H-fluoren-9-ylmethyl carbonochloridate(9H-Fluoren-9-ylmethoxy)carbonyl Chloride

Datenbank-Bezeichner

CAS
28920-43-6
PubChem CID
34367
DTXSID
DTXSID10183116
UNII
9PLB0BTT90
EC Number
249-313-6
Nikkaji
J311E

Eigenschaften

Berechnete Struktureigenschaften

XLogP
4,3
Polarare Oberfläche (TPSA)
26,3 Ų
H-Brücken-Donoren
0
H-Brücken-Akzeptoren
2
Frei drehbare Bindungen
3
Schwere Atome
18

Physikochemische Eigenschaften

Schmelzpunkt
62 · 62-64 °C(lit.)
Siedepunkt
365.79 °C · 365.79°C (rough estimate)
Dichte
1.178 · 1.1780 (rough estimate)
Brechungsindex
1.533 · 1.5330 (estimate)
storage temp.
2 · 2-8°C
Löslichkeit
0.1 g/mL, · dioxane: 0.1 g/mL, clear, colorless

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Danger

H302 (17.5%): Harmful if swallowed [Warning Acute toxicity, oral]

P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P363, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 80 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Regulatory Information · 3 Einträge

Chemical: Carbonochloridic acid, 9H-fluoren-9-ylmethyl ester

Status: Active Update: 29-03-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/28092

(9-Fluorenylmethyl) chloroformate: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationEvaluation - Chemicals that are unlikely to require further regulation to manage risks to human health
Hazard Classes and CategoriesAcute Tox. 4 (17.5%)

Sicherheitsdaten

F
10-21
wgk
3
tsca
No
ridadr
UN 3261 8/PG 2
hs_code
29159020
RTECS-Nr.
LQ6250000

Chemie und Industrie

Pharmakologische Informationen

MeSH Pharmacological Classification · 1 Eintrag

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)

Anwendungen · 2 Einträge

Beschreibung9-Fluorenylmethyl chloroformate (Fmoc-C1) is a significant biochemical reagent introduced by Carpino. It has been widely utilized as a reagent for the introduction of the 9-fluorenylmethoxycarbonyl (Fmoc moiety) in both peptide and nucleotide synthesis, as well as serving as a coupling agent in peptide synthesis[1]. Furthermore, Fmoc-C1 can function as a versatile fluorescent labeling reagent for primary and secondary amines[2].

Verwenden9-Fluorenylmethyl chloroformate is an N-Protecting agent for peptides research and was used for the pre-column derivatization of the biogenic amines (BAs) cadaverine (Cad), histamine (Him), octopami ne (Ocp), phenylethylamine (Pea), putrescine (Put), spermidine (Spd), spermine (Spm), tyramine (Tym).

Anbieter50 Anbieter

国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
新乡市巨源生物科技有限公司373-5071400 13937360405 · [email protected]

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